[Term]
id: PR:000046994
name: collagen alpha-1(VIII) chain, signal peptide removed 4-hydroxy-proline form (human)
def: "A collagen alpha-1(VIII) chain (human) that has had the signal peptide removed and that includes at least one 4-hydroxy-proline. UniProtKB:P27658, 28-744, MOD:00039." [PRO:DNx, Reactome:R-HSA-2172948]
comment: Category=organism-modification.
synonym: "hCOL8A1/SigPep-/4HyPro+" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000005762, MOD:00039" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P27658, 28-744, MOD:00039" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-2172948 "PR:000046994 located_in GO:0005788"
intersection_of: has_part MOD:00039 ! 4-hydroxy-L-proline
intersection_of: PR:P27658 ! collagen alpha-1(VIII) chain (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000039175
name: collagen alpha-1(VIII) chain isoform 1
def: "A collagen alpha-1(VIII) chain that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P27658-1 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "COL8A1/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000005720 ! collagen alpha-1(VIII) chain

[Term]
id: PR:000046996
name: collagen alpha-1(VIII) chain, signal peptide removed 5-hydroxy-lysine, 3-hydroxy-proline and 4-hydroxy-proline form (human)
def: "A collagen alpha-1(VIII) chain (human) that has had the signal peptide removed and that includes at least one 5-hydroxy-lysine, at least one 3-hydroxy-proline and at least one 4-hydroxy-proline. UniProtKB:P27658, 28-744, MOD:00037|MOD:00038|MOD:00039." [PRO:DNx, Reactome:R-HSA-2173217, Reactome:R-HSA-2192732]
comment: Category=organism-modification.
synonym: "hCOL8A1/SigPep-/5hL3hP4hP+" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000005762, MOD:00037|MOD:00038|MOD:00039" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P27658, 28-744, MOD:00037|MOD:00038|MOD:00039" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-2173217 "PR:000046996 located_in GO:0005788"
xref: Reactome:R-HSA-2192732 "PR:000046996 located_in GO:0005576"
intersection_of: has_part MOD:00037 ! 5-hydroxy-L-lysine
intersection_of: has_part MOD:00038 ! 3-hydroxy-L-proline
intersection_of: has_part MOD:00039 ! 4-hydroxy-L-proline
intersection_of: PR:P27658 ! collagen alpha-1(VIII) chain (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000046997
name: collagen alpha-1(VIII) chain, signal peptide removed 5-hydroxy-lysine and 4-hydroxy-proline form (human)
def: "A collagen alpha-1(VIII) chain (human) that has had the signal peptide removed and that includes at least one 5-hydroxy-lysine and at least one 4-hydroxy-proline. UniProtKB:P27658, 28-744, MOD:00037|MOD:00039." [PRO:DNx, Reactome:R-HSA-2173143, Reactome:R-HSA-2192750]
comment: Category=organism-modification.
synonym: "hCOL8A1/SigPep-/5hL4hP+" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000005762, MOD:00037|MOD:00039" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P27658, 28-744, MOD:00037|MOD:00039" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-2173143 "PR:000046997 located_in GO:0005788"
xref: Reactome:R-HSA-2192750 "PR:000046997 located_in GO:0005576"
intersection_of: has_part MOD:00037 ! 5-hydroxy-L-lysine
intersection_of: has_part MOD:00039 ! 4-hydroxy-L-proline
intersection_of: PR:P27658 ! collagen alpha-1(VIII) chain (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000046991
name: collagen alpha-1(VIII) chain 4-hydroxy-proline form (human)
def: "A collagen alpha-1(VIII) chain (human) that includes at least one 4-hydroxy-proline. UniProtKB:P27658, MOD:00039." [PRO:DNx, Reactome:R-HSA-2192733]
comment: Category=organism-modification.
synonym: "hCOL8A1/4HyPro+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P27658, MOD:00039" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-2192733 "PR:000046991 located_in GO:0005576"
intersection_of: has_part MOD:00039 ! 4-hydroxy-L-proline
intersection_of: PR:P27658 ! collagen alpha-1(VIII) chain (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000046992
name: collagen alpha-1(VIII) chain, signal peptide removed form (human)
def: "A collagen alpha-1(VIII) chain (human) that has had the signal peptide removed. UniProtKB:P27658, 28-744." [PRO:DNx, Reactome:R-HSA-2172239, Reactome:R-HSA-2192738]
comment: Category=organism-modification.
synonym: "PRO_0000005762" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hCOL8A1/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P27658, 28-744" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-2172239 "PR:000046992 located_in GO:0005788"
xref: Reactome:R-HSA-2192738 "PR:000046992 located_in GO:0005576"
intersection_of: PR:P27658 ! collagen alpha-1(VIII) chain (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000046993
name: collagen alpha-1(VIII) chain, signal peptide removed 3-hydroxy-proline and 4-hydroxy-proline form (human)
def: "A collagen alpha-1(VIII) chain (human) that has had the signal peptide removed and that includes at least one 3-hydroxy-proline and at least one 4-hydroxy-proline. UniProtKB:P27658, 28-744, MOD:00038|MOD:00039." [PRO:DNx, Reactome:R-HSA-2172976, Reactome:R-HSA-2192740]
comment: Category=organism-modification.
synonym: "hCOL8A1/SigPep-/3hP4hP+" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000005762, MOD:00038|MOD:00039" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P27658, 28-744, MOD:00038|MOD:00039" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-2172976 "PR:000046993 located_in GO:0005788"
xref: Reactome:R-HSA-2192740 "PR:000046993 located_in GO:0005576"
intersection_of: has_part MOD:00038 ! 3-hydroxy-L-proline
intersection_of: has_part MOD:00039 ! 4-hydroxy-L-proline
intersection_of: PR:P27658 ! collagen alpha-1(VIII) chain (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000019412
name: collagen alpha-1(VIII) chain proteolytic cleavage product
def: "A collagen alpha-1(VIII) chain that has been processed by proteolytic cleavage." [PRO:DNx]
comment: Category=modification.
synonym: "COL8A1/ClvPrd" EXACT PRO-short-label [PRO:DNx]
intersection_of: output_of GO:0016485 ! protein processing
intersection_of: PR:000005720 ! collagen alpha-1(VIII) chain

[Term]
id: PR:000056313
name: collagen alpha-1(VIII) chain O-glycosylated 1 (human)
def: "A collagen alpha-1(VIII) chain (human) that has been O-glycosylated at the residue equivalent to Thr-577 of the amino acid sequence represented by UniProtKB:P27658-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P27658-1, Thr-577, MOD:00005~GNO:G43417UB." [GlyGen:P27658-1, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hCOL8A1/OGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P27658-1, Thr-577, MOD:00005~GNO:G43417UB" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P27658 ! collagen alpha-1(VIII) chain (human)
relationship: has_part GNO:G43417UB ! G43417UB
relationship: has_part MOD:00005 ! O-glycosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000005720
name: collagen alpha-1(VIII) chain
def: "A protein that is a translation product of the human COL8A1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "C3orf7" RELATED Gene-based []
synonym: "COL8A1" EXACT PRO-short-label [PRO:DNx]
synonym: "endothelial collagen" BROAD [PRO:DNx]
is_a: PR:000000001 ! protein

[Term]
id: PR:000046995
name: collagen alpha-1(VIII) chain, signal peptide removed 5-hydroxy-lysine form (human)
def: "A collagen alpha-1(VIII) chain (human) that has had the signal peptide removed and that includes at least one 5-hydroxy-lysine. UniProtKB:P27658, 28-744, MOD:00037." [PRO:DNx, Reactome:R-HSA-2173023, Reactome:R-HSA-2192741]
comment: Category=organism-modification.
synonym: "hCOL8A1/SigPep-/5HyLys+" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000005762, MOD:00037" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P27658, 28-744, MOD:00037" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-2173023 "PR:000046995 located_in GO:0005788"
xref: Reactome:R-HSA-2192741 "PR:000046995 located_in GO:0005576"
intersection_of: has_part MOD:00037 ! 5-hydroxy-L-lysine
intersection_of: PR:P27658 ! collagen alpha-1(VIII) chain (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P27658
name: collagen alpha-1(VIII) chain (human)
def: "A collagen alpha-1(VIII) chain that is encoded in the genome of human." [PRO:DNx, UniProtKB:P27658]
comment: Category=organism-gene.
synonym: "C3orf7" RELATED Gene-based [UniProtKB:P27658]
synonym: "COL8A1" RELATED Gene-based [UniProtKB:P27658]
synonym: "hCOL8A1" EXACT PRO-short-label [PRO:DNx]
synonym: "endothelial collagen (human)" BROAD [UniProtKB:P27658]
xref: UniProtKB:P27658
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000005720 ! collagen alpha-1(VIII) chain
relationship: has_gene_template HGNC:2215 ! COL8A1 (human)

[Term]
id: PR:P27658-1
name: collagen alpha-1(VIII) chain isoform 1 (human)
def: "A collagen alpha-1(VIII) chain isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hCOL8A1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P27658-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000039175 ! collagen alpha-1(VIII) chain isoform 1

[Term]
id: PR:Q9V9W8
name: protein pygopus (fruit fly)
def: "A collagen alpha-1(VIII) chain that is encoded in the genome of fruit fly." [PRO:DNx]
comment: Category=organism-gene.
synonym: "gam" RELATED Gene-based [UniProtKB:Q9V9W8]
synonym: "pygo" RELATED Gene-based [UniProtKB:Q9V9W8]
synonym: "CG11518" RELATED Gene-based [UniProtKB:Q9V9W8]
synonym: "fly-COL8A1" EXACT PRO-short-label [PRO:DNx]
synonym: "protein gammy legs (fruit fly)" EXACT [UniProtKB:Q9V9W8]
xref: UniProtKB:Q9V9W8
intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster
intersection_of: PR:000005720 ! collagen alpha-1(VIII) chain
relationship: has_gene_template FlyBase:FBgn0043900 ! pygo (fruit fly)

[Term]
id: PR:Q7LZR2-1
name: collagen alpha-1(VIII) chain isoform 1 (chicken)
def: "A collagen alpha-1(VIII) chain isoform 1 that is encoded in the genome of chicken." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "chick-COL8A1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q7LZR2-1
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000039175 ! collagen alpha-1(VIII) chain isoform 1

[Term]
id: PR:Q00780
name: collagen alpha-1(VIII) chain (mouse)
def: "A collagen alpha-1(VIII) chain that is encoded in the genome of mouse." [OMA:Q00780, PRO:DNx]
comment: Category=organism-gene.
synonym: "Col8a1" RELATED Gene-based [UniProtKB:Q00780]
synonym: "mCOL8A1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q00780
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000005720 ! collagen alpha-1(VIII) chain
relationship: has_gene_template MGI:88463 ! Col8a1 (mouse)