[Term]
id: PR:P16220-3
name: cyclic AMP-responsive element-binding protein 1 isoform h3 (human)
def: "A cyclic AMP-responsive element-binding protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P16220-3." [PRO:DNx, UniProtKB:P16220]
comment: Category=organism-sequence.
synonym: "hCREB1/iso:h3" EXACT PRO-short-label [PRO:DNx]
synonym: "cyclic AMP-responsive element-binding protein 1 isoform htCREB (human)" EXACT [UniProtKB:P16220]
xref: UniProtKB:P16220-3
is_a: PR:P16220 ! cyclic AMP-responsive element-binding protein 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P16220-2
name: cyclic AMP-responsive element-binding protein 1 isoform 2 (human)
def: "A cyclic AMP-responsive element-binding protein 1 isoform 2 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "CREB-B" RELATED Gene-based [UniProtKB:P16220]
synonym: "hCREB1/iso:2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P16220-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000028633 ! cyclic AMP-responsive element-binding protein 1 isoform 2

[Term]
id: PR:P16220-1
name: cyclic AMP-responsive element-binding protein 1 isoform 1 (human)
def: "A cyclic AMP-responsive element-binding protein 1 isoform 1 that is encoded in the genome of human." [PRO:PD]
comment: Category=organism-sequence.
synonym: "CREB-A" RELATED Gene-based [UniProtKB:P16220]
synonym: "hCREB1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P16220-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000028638 ! cyclic AMP-responsive element-binding protein 1 isoform 1

[Term]
id: PR:000045687
name: cyclic AMP-responsive element-binding protein 1 phosphorylated 1 (human)
def: "A cyclic AMP-responsive element-binding protein 1 (human) that has been phosphorylated on the residue at the position equivalent to Ser-133 of the amino acid sequence represented by UniProtKB:P16220-1. Example: UniProtKB:P16220-1, Ser-133, MOD:00046." [PMID:11988169, PMID:12356771, PMID:15733869, PMID:17426037, PMID:20484048, PMID:7608156, PMID:8887554, PMID:9528766, PMID:9770464, PMID:9829964, iPTMnet:P16220]
comment: Category=organism-modification. Requested by=ImmPort. Evidence=(ECO:0000006, based on PMID:12356771, PMID:15733869, PMID:17426037, PMID:20484048, PMID:7608156, PMID:8887554, PMID:9528766, PMID:9770464, PMID:9829964). Status=unreviewed.
synonym: "hCREB1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "hCREB1 (pSer133)" EXACT [PRO:ADD, GOC:add]
synonym: "UniProtKB:P16220-1, Ser-133, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-111910 "PR:000045687 located_in GO:0005654"
is_a: PR:P16220 ! cyclic AMP-responsive element-binding protein 1 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000028641
name: cyclic AMP-responsive element-binding protein 1 isoform 1 acetylated 1 (human)
def: "A cyclic AMP-responsive element-binding protein 1 isoform 1 acetylated 1 in human. UniProtKB:P16220-1, Lys-91/Lys-94/Lys-136, MOD:00064." [PMID:12595525, PRO:PD]
comment: Category=organism-modification. Acetylase=("CREBBP"; PR:Q92793; Lys-91/Lys-94/Lys-136).
synonym: "hCREB1/iso:1/Ac:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P16220-1, Lys-91/Lys-94/Lys-136, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000028640 ! cyclic AMP-responsive element-binding protein 1 isoform 1 acetylated 1
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine

[Term]
id: PR:P16220
name: cyclic AMP-responsive element-binding protein 1 (human)
def: "A cyclic AMP-responsive element-binding protein 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P16220]
comment: Category=organism-gene.
synonym: "CREB1" RELATED Gene-based [UniProtKB:P16220]
synonym: "hCREB1" EXACT PRO-short-label [PRO:DNx]
synonym: "CREB-1 (human)" EXACT [UniProtKB:P16220]
synonym: "cAMP-responsive element-binding protein 1 (human)" EXACT [UniProtKB:P16220]
xref: Reactome:R-HSA-52777 "PR:P16220 located_in GO:0005654"
xref: UniProtKB:P16220
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000005854 ! cyclic AMP-responsive element-binding protein 1
relationship: has_gene_template HGNC:2345 ! CREB1 (human)

[Term]
id: PR:000005854
name: cyclic AMP-responsive element-binding protein 1
def: "A protein that is a translation product of the human CREB1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "CREB1" EXACT PRO-short-label [PRO:DNx]
synonym: "CREB-1" EXACT []
synonym: "cAMP-responsive element-binding protein 1" EXACT []
is_a: PR:000000001 ! protein