[Term]
id: PR:000006030
name: procathepsin L
def: "A cathepsin-like protease that is a translation product of the human CTSL gene or a 1:1 ortholog thereof." [PRO:DAN]
comment: Category=gene.
synonym: "MEP" RELATED []
synonym: "CTSL" EXACT PRO-short-label [PRO:DNx]
synonym: "CTSL1" RELATED Gene-based []
synonym: "cathepsin L1" EXACT []
synonym: "major excreted protein" EXACT []
synonym: "p39 cysteine proteinase" EXACT []
xref: IUPHARobj:2351
is_a: PR:000040662 ! cathepsin-like protease

[Term]
id: PR:000019573
name: procathepsin L, signal peptide removed form
def: "A procathepsin L that has had the signal peptide removed." [PRO:DNx]
comment: Category=modification.
synonym: "CTSL/SigPep-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000006030 ! procathepsin L
intersection_of: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:P07711-1
name: procathepsin L isoform h1 (human)
def: "A procathepsin L (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P07711-1." [PRO:DNx, UniProtKB:P07711]
comment: Category=organism-sequence.
synonym: "hCTSL/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P07711-1
is_a: PR:P07711 ! procathepsin L (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000019574
name: procathepsin L proteolytic cleavage product
def: "A procathepsin L that has been processed by proteolytic cleavage." [PRO:DNx]
comment: Category=modification.
synonym: "CTSL/ClvPrd" EXACT PRO-short-label [PRO:DNx]
intersection_of: output_of GO:0016485 ! protein processing
intersection_of: PR:000006030 ! procathepsin L

[Term]
id: PR:P07711-3
name: procathepsin L isoform h2 (human)
def: "A procathepsin L (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P07711-3." [PRO:DNx, UniProtKB:P07711]
comment: Category=organism-sequence.
synonym: "hCTSL/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P07711-3
is_a: PR:P07711 ! procathepsin L (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000053979
name: procathepsin L N-glycosylated 1 (human)
def: "A procathepsin L (human) that has been N-glycosylated at the residue equivalent to Asn-221 of the amino acid sequence represented by UniProtKB:P07711-1, in which the glycan composition is represented by GlyTouCan:G02815KT. Example: UniProtKB:P07711-1, Asn-221, MOD:00160~GNO:G02815KT." [GlyGen:P07711-1, PMID:26791533, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hCTSL/NGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P07711-1, Asn-221, MOD:00160~GNO:G02815KT" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P07711 ! procathepsin L (human)
relationship: has_part GNO:G02815KT ! G02815KT
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P07711
name: procathepsin L (human)
def: "A procathepsin L that is encoded in the genome of human." [PRO:DNx, UniProtKB:P07711]
comment: Category=organism-gene. Requested by=PubChem.
synonym: "CTSL" RELATED Gene-based [UniProtKB:P07711]
synonym: "CTSL1" RELATED Gene-based [UniProtKB:P07711]
synonym: "hCTSL" EXACT PRO-short-label [PRO:DNx]
synonym: "MEP (human)" BROAD [UniProtKB:P07711]
synonym: "cathepsin L1 (human)" EXACT [UniProtKB:P07711]
synonym: "major excreted protein (human)" EXACT [UniProtKB:P07711]
xref: UniProtKB:P07711
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000006030 ! procathepsin L
relationship: has_gene_template HGNC:2537 ! CTSL (human)