[Term] id: PR:000006147 name: lanosterol 14-alpha demethylase def: "A protein that is a translation product of the human CYP51A1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "LDM" EXACT [] synonym: "CYP51" RELATED Gene-based [] synonym: "CYPLI" EXACT [] synonym: "CYP51A1" EXACT PRO-short-label [PRO:DNx] synonym: "cytochrome P450LI" EXACT [] synonym: "cytochrome P45014DM" EXACT [] synonym: "cytochrome P450 51A1" EXACT [] synonym: "cytochrome P450-14DM" EXACT [] synonym: "sterol 14-alpha demethylase" EXACT [] xref: IUPHARobj:1374 is_a: PR:000000001 ! protein [Term] id: PR:Q64654 name: lanosterol 14-alpha demethylase (rat) def: "A lanosterol 14-alpha demethylase that is encoded in the genome of rat." [OMA:Q64654, PANTHER:PTHR24286:SF13, PRO:DNx] comment: Category=organism-gene. synonym: "Cyp51" RELATED Gene-based [UniProtKB:Q64654] synonym: "Cyp51a1" RELATED Gene-based [UniProtKB:Q64654] synonym: "rCYP51A1" EXACT PRO-short-label [PRO:DNx] synonym: "LDM (rat)" EXACT [UniProtKB:Q64654] synonym: "CYPLI (rat)" EXACT [UniProtKB:Q64654] synonym: "cytochrome P450LI (rat)" EXACT [UniProtKB:Q64654] synonym: "cytochrome P45014DM (rat)" EXACT [UniProtKB:Q64654] synonym: "cytochrome P450 51A1 (rat)" EXACT [UniProtKB:Q64654] synonym: "cytochrome P450-14DM (rat)" EXACT [UniProtKB:Q64654] synonym: "sterol 14-alpha demethylase (rat)" EXACT [UniProtKB:Q64654] xref: UniProtKB:Q64654 intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus intersection_of: PR:000006147 ! lanosterol 14-alpha demethylase relationship: has_gene_template RGD:2481 ! Cyp51 (rat) [Term] id: PR:Q16850-2 name: lanosterol 14-alpha demethylase isoform h2 (human) def: "A lanosterol 14-alpha demethylase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q16850-2." [PRO:DNx, UniProtKB:Q16850] comment: Category=organism-sequence. synonym: "hCYP51A1/iso:h2" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q16850-2 is_a: PR:Q16850 ! lanosterol 14-alpha demethylase (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q16850-1 name: lanosterol 14-alpha demethylase isoform 1 (human) def: "A lanosterol 14-alpha demethylase isoform 1 that is encoded in the genome of human." [PRO:DNx] comment: Category=organism-sequence. synonym: "hCYP51A1/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q16850-1 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000040749 ! lanosterol 14-alpha demethylase isoform 1 [Term] id: PR:Q1ZXH9 name: probable lanosterol 14-alpha demethylase (Dictyostelium discoideum) def: "A lanosterol 14-alpha demethylase that is encoded in the genome of Dictyostelium discoideum." [OMA:Q1ZXH9, PRO:DNx] comment: Category=organism-gene. synonym: "cyp51" RELATED Gene-based [UniProtKB:Q1ZXH9] synonym: "DDB_G0279403" RELATED Gene-based [UniProtKB:Q1ZXH9] synonym: "Dicty-CYP51A1" EXACT PRO-short-label [PRO:DNx] synonym: "LDM (Dictyostelium discoideum)" EXACT [UniProtKB:Q1ZXH9] synonym: "cytochrome P450 51 (Dictyostelium discoideum)" EXACT [UniProtKB:Q1ZXH9] synonym: "cytochrome P450-14DM (Dictyostelium discoideum)" EXACT [UniProtKB:Q1ZXH9] synonym: "sterol 14-demethylase (Dictyostelium discoideum)" EXACT [UniProtKB:Q1ZXH9] xref: UniProtKB:Q1ZXH9 intersection_of: only_in_taxon NCBITaxon:44689 ! Dictyostelium discoideum intersection_of: PR:000006147 ! lanosterol 14-alpha demethylase relationship: has_gene_template dictyBase:DDB_G0279403 ! cyp51 (Dictyostelium discoideum) [Term] id: PR:Q9SAA9 name: sterol 14-demethylase (Arabidopsis thaliana) def: "A lanosterol 14-alpha demethylase that is encoded in the genome of Arabidopsis thaliana." [OMA:Q9SAA9, PRO:DNx] comment: Category=organism-gene. synonym: "AtCYP51" EXACT [UniProtKB:Q9SAA9] synonym: "CYP51A2" RELATED Gene-based [UniProtKB:Q9SAA9] synonym: "CYP51G1" RELATED Gene-based [UniProtKB:Q9SAA9] synonym: "EMB1738" RELATED Gene-based [UniProtKB:Q9SAA9] synonym: "At1g11680" RELATED Gene-based [UniProtKB:Q9SAA9] synonym: "F25C20.17" RELATED Gene-based [UniProtKB:Q9SAA9] synonym: "At-CYP51A1" EXACT PRO-short-label [PRO:DNx] synonym: "cytochrome P450 51A2 (Arabidopsis thaliana)" EXACT [UniProtKB:Q9SAA9] synonym: "cytochrome P450 51G1 (Arabidopsis thaliana)" EXACT [UniProtKB:Q9SAA9] synonym: "obtusifoliol 14-demethylase (Arabidopsis thaliana)" EXACT [UniProtKB:Q9SAA9] synonym: "protein EMBRYO DEFECTIVE 1738 (Arabidopsis thaliana)" EXACT [UniProtKB:Q9SAA9] xref: UniProtKB:Q9SAA9 intersection_of: only_in_taxon NCBITaxon:3702 ! Arabidopsis thaliana intersection_of: PR:000006147 ! lanosterol 14-alpha demethylase relationship: has_gene_template Araport:AT1G11680 ! CYP51G1 (Arabidopsis thaliana) [Term] id: PR:P10614 name: lanosterol 14-alpha demethylase CYP51 (yeast) def: "A lanosterol 14-alpha demethylase that is encoded in the genome of yeast." [OMA:P10614, PANTHER:PTHR24286:SF13, PRO:DNx] comment: Category=organism-gene. synonym: "CYP51" RELATED Gene-based [UniProtKB:P10614] synonym: "ERG11" RELATED Gene-based [UniProtKB:P10614] synonym: "YHR007C" RELATED Gene-based [UniProtKB:P10614] synonym: "yCYP51A1" EXACT PRO-short-label [PRO:DNx] synonym: "CYPLI (yeast)" EXACT [UniProtKB:P10614] synonym: "cytochrome P450 51 (yeast)" EXACT [UniProtKB:P10614] synonym: "cytochrome P450-14DM (yeast)" EXACT [UniProtKB:P10614] synonym: "cytochrome P450-LIA1 (yeast)" EXACT [UniProtKB:P10614] synonym: "sterol 14-alpha demethylase (yeast)" EXACT [UniProtKB:P10614] synonym: "ergosterol biosynthetic protein 11 (yeast)" EXACT [UniProtKB:P10614] xref: UniProtKB:P10614 intersection_of: only_in_taxon NCBITaxon:559292 ! Saccharomyces cerevisiae S288C intersection_of: PR:000006147 ! lanosterol 14-alpha demethylase relationship: has_gene_template SGD:S000001049 ! ERG11 (yeast) [Term] id: PR:000040749 name: lanosterol 14-alpha demethylase isoform 1 def: "A lanosterol 14-alpha demethylase that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q16850-1 or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=sequence. synonym: "CYP51A1/iso:1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000006147 ! lanosterol 14-alpha demethylase [Term] id: PR:Q1JPY5 name: lanosterol 14-alpha demethylase (zebrafish) def: "A lanosterol 14-alpha demethylase that is encoded in the genome of zebrafish." [OMA:Q1JPY5, PANTHER:PTHR24286:SF13, PRO:DNx] comment: Category=organism-gene. synonym: "cyp51" RELATED Gene-based [UniProtKB:Q1JPY5] synonym: "z-CYP51A1" EXACT PRO-short-label [PRO:DNx] synonym: "LDM (zebrafish)" EXACT [UniProtKB:Q1JPY5] synonym: "CYP51 (zebrafish)" EXACT [UniProtKB:Q1JPY5] synonym: "sterol 14-alpha demethylase (zebrafish)" EXACT [UniProtKB:Q1JPY5] synonym: "cytochrome P450 family member 51 (zebrafish)" EXACT [UniProtKB:Q1JPY5] xref: UniProtKB:Q1JPY5 intersection_of: only_in_taxon NCBITaxon:7955 ! Danio rerio intersection_of: PR:000006147 ! lanosterol 14-alpha demethylase relationship: has_gene_template ZFIN:ZDB-GENE-040625-2 ! cyp51 (zebrafish) [Term] id: PR:Q09736 name: lanosterol 14-alpha demethylase erg11 (Schizosaccharomyces pombe 972h-) def: "A lanosterol 14-alpha demethylase that is encoded in the genome of Schizosaccharomyces pombe 972h-." [OMA:Q09736, PANTHER:PTHR24286:SF13, PRO:DNx] comment: Category=organism-gene. synonym: "cyp51" RELATED Gene-based [UniProtKB:Q09736] synonym: "erg11" RELATED Gene-based [UniProtKB:Q09736] synonym: "SPAC13A11.02c" RELATED Gene-based [UniProtKB:Q09736] synonym: "Spom972h-CYP51A1" EXACT PRO-short-label [PRO:DNx] synonym: "cytochrome P450 51 (Schizosaccharomyces pombe 972h-)" EXACT [UniProtKB:Q09736] synonym: "sterol 14-alpha demethylase (Schizosaccharomyces pombe 972h-)" EXACT [UniProtKB:Q09736] synonym: "ergosterol biosynthetic protein 11 (Schizosaccharomyces pombe 972h-)" EXACT [UniProtKB:Q09736] xref: UniProtKB:Q09736 intersection_of: only_in_taxon NCBITaxon:284812 ! Schizosaccharomyces pombe 972h- intersection_of: PR:000006147 ! lanosterol 14-alpha demethylase relationship: has_gene_template PomBase:SPAC13A11.02c ! erg11 (Schizosaccharomyces pombe) [Term] id: PR:Q16850 name: lanosterol 14-alpha demethylase (human) def: "A lanosterol 14-alpha demethylase that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q16850] comment: Category=organism-gene. synonym: "CYP51" RELATED Gene-based [UniProtKB:Q16850] synonym: "CYP51A1" RELATED Gene-based [UniProtKB:Q16850] synonym: "hCYP51A1" EXACT PRO-short-label [PRO:DNx] synonym: "LDM (human)" EXACT [UniProtKB:Q16850] synonym: "CYPLI (human)" EXACT [UniProtKB:Q16850] synonym: "cytochrome P450LI (human)" EXACT [UniProtKB:Q16850] synonym: "cytochrome P45014DM (human)" EXACT [UniProtKB:Q16850] synonym: "cytochrome P450 51A1 (human)" EXACT [UniProtKB:Q16850] synonym: "cytochrome P450-14DM (human)" EXACT [UniProtKB:Q16850] synonym: "sterol 14-alpha demethylase (human)" EXACT [UniProtKB:Q16850] xref: Reactome:R-HSA-194721 "PR:Q16850 located_in GO:0005789" xref: UniProtKB:Q16850 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000006147 ! lanosterol 14-alpha demethylase relationship: has_gene_template HGNC:2649 ! CYP51A1 (human) [Term] id: PR:Q8K0C4-1 name: lanosterol 14-alpha demethylase isoform 1 (mouse) def: "A lanosterol 14-alpha demethylase isoform 1 that is encoded in the genome of mouse." [PRO:DNx] comment: Category=organism-sequence. synonym: "mCYP51A1/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q8K0C4-1 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000040749 ! lanosterol 14-alpha demethylase isoform 1 [Term] id: PR:Q8K0C4 name: lanosterol 14-alpha demethylase (mouse) def: "A lanosterol 14-alpha demethylase that is encoded in the genome of mouse." [OMA:Q8K0C4, PRO:DAN] comment: Category=organism-gene. synonym: "Cyp51" RELATED Gene-based [UniProtKB:Q8K0C4] synonym: "Cyp51a1" RELATED Gene-based [UniProtKB:Q8K0C4] synonym: "mCYP51A1" EXACT PRO-short-label [PRO:DNx] synonym: "LDM (mouse)" EXACT [UniProtKB:Q8K0C4] synonym: "CYPLI (mouse)" EXACT [UniProtKB:Q8K0C4] synonym: "cytochrome P450LI (mouse)" EXACT [UniProtKB:Q8K0C4] synonym: "cytochrome P45014DM (mouse)" EXACT [UniProtKB:Q8K0C4] synonym: "cytochrome P450 51A1 (mouse)" EXACT [UniProtKB:Q8K0C4] synonym: "cytochrome P450-14DM (mouse)" EXACT [UniProtKB:Q8K0C4] synonym: "sterol 14-alpha demethylase (mouse)" EXACT [UniProtKB:Q8K0C4] xref: UniProtKB:Q8K0C4 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000006147 ! lanosterol 14-alpha demethylase relationship: has_gene_template MGI:106040 ! Cyp51 (mouse) [Term] id: PR:Q64654-1 name: lanosterol 14-alpha demethylase isoform 1 (rat) def: "A lanosterol 14-alpha demethylase isoform 1 that is encoded in the genome of rat." [PRO:DNx] comment: Category=organism-sequence. synonym: "rCYP51A1/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q64654-1 intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus intersection_of: PR:000040749 ! lanosterol 14-alpha demethylase isoform 1