[Term] id: PR:Q9NRI5-8 name: disrupted in schizophrenia 1 protein isoform h8 (human) def: "A disrupted in schizophrenia 1 protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NRI5-8." [PRO:DNx, UniProtKB:Q9NRI5] comment: Category=organism-sequence. synonym: "hDISC1/iso:h8" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q9NRI5-8 is_a: PR:Q9NRI5 ! disrupted in schizophrenia 1 protein (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q9NRI5-9 name: disrupted in schizophrenia 1 protein isoform h9 (human) def: "A disrupted in schizophrenia 1 protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NRI5-9." [PRO:DNx, UniProtKB:Q9NRI5] comment: Category=organism-sequence. synonym: "hDISC1/iso:h9" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q9NRI5-9 is_a: PR:Q9NRI5 ! disrupted in schizophrenia 1 protein (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000035602 name: disrupted in schizophrenia 1 protein isoform 1 phosphorylated 1 (mouse) def: "A disrupted in schizophrenia 1 protein isoform 1 phosphorylated 1 in mouse. UniProtKB:Q811T9-1, Ser-710, MOD:00046." [PMID:21471969, PRO:KRC] comment: Category=organism-modification. synonym: "mDISC1/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "DISC1 phosphorylated" RELATED [] synonym: "UniProtKB:Q811T9-1, Ser-710, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000035600 ! disrupted in schizophrenia 1 protein isoform 1 phosphorylated 1 relationship: has_part MOD:00046 ! O-phospho-L-serine [Term] id: PR:Q9NRI5-1 name: disrupted in schizophrenia 1 protein isoform h1 (human) def: "A disrupted in schizophrenia 1 protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NRI5-1." [PRO:DNx, UniProtKB:Q9NRI5] comment: Category=organism-sequence. synonym: "hDISC1/iso:h1" EXACT PRO-short-label [PRO:DNx] synonym: "disrupted in schizophrenia 1 protein isoform L (human)" EXACT [UniProtKB:Q9NRI5] xref: UniProtKB:Q9NRI5-1 is_a: PR:Q9NRI5 ! disrupted in schizophrenia 1 protein (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000035600 name: disrupted in schizophrenia 1 protein isoform 1 phosphorylated 1 def: "A disrupted in schizophrenia 1 protein isoform 1 that has been phosphorylated on a residue equivalent to Ser-710 of the amino acid sequence represented by UniProtKB:Q811T9-1. Example: UniProtKB:Q811T9-1, Ser-710, MOD:00046." [PMID:21471969, PRO:KRC] comment: Category=modification. synonym: "DISC1/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "DISC1 phosphorylated" RELATED [] is_a: PR:000035601 ! disrupted in schizophrenia 1 protein isoform 1 relationship: has_part MOD:00046 ! O-phospho-L-serine [Term] id: PR:000035601 name: disrupted in schizophrenia 1 protein isoform 1 def: "A disrupted in schizophrenia 1 protein that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q811T9-1 or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=sequence. synonym: "DISC1/iso:1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000006494 ! disrupted in schizophrenia 1 protein [Term] id: PR:Q9NRI5-4 name: disrupted in schizophrenia 1 protein isoform h4 (human) def: "A disrupted in schizophrenia 1 protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NRI5-4." [PRO:DNx, UniProtKB:Q9NRI5] comment: Category=organism-sequence. synonym: "hDISC1/iso:h4" EXACT PRO-short-label [PRO:DNx] synonym: "disrupted in schizophrenia 1 protein isoform ES (human)" EXACT [UniProtKB:Q9NRI5] xref: UniProtKB:Q9NRI5-4 is_a: PR:Q9NRI5 ! disrupted in schizophrenia 1 protein (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q9NRI5-5 name: disrupted in schizophrenia 1 protein isoform h5 (human) def: "A disrupted in schizophrenia 1 protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NRI5-5." [PRO:DNx, UniProtKB:Q9NRI5] comment: Category=organism-sequence. synonym: "hDISC1/iso:h5" EXACT PRO-short-label [PRO:DNx] synonym: "disrupted in schizophrenia 1 protein isoform 26 (human)" EXACT [UniProtKB:Q9NRI5] xref: UniProtKB:Q9NRI5-5 is_a: PR:Q9NRI5 ! disrupted in schizophrenia 1 protein (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q9NRI5-6 name: disrupted in schizophrenia 1 protein isoform h6 (human) def: "A disrupted in schizophrenia 1 protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NRI5-6." [PRO:DNx, UniProtKB:Q9NRI5] comment: Category=organism-sequence. synonym: "hDISC1/iso:h6" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q9NRI5-6 is_a: PR:Q9NRI5 ! disrupted in schizophrenia 1 protein (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q9NRI5-7 name: disrupted in schizophrenia 1 protein isoform h7 (human) def: "A disrupted in schizophrenia 1 protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NRI5-7." [PRO:DNx, UniProtKB:Q9NRI5] comment: Category=organism-sequence. synonym: "hDISC1/iso:h7" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q9NRI5-7 is_a: PR:Q9NRI5 ! disrupted in schizophrenia 1 protein (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q811T9-4 name: disrupted in schizophrenia 1 protein isoform 4 (mouse) def: "A disrupted in schizophrenia 1 homolog (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q811T9-4." [PMID:12573262, PRO:HJD] comment: Category=organism-sequence. synonym: "ES isoform" RELATED [] synonym: "mDISC1/iso:4" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q811T9-4 is_a: PR:Q811T9 ! disrupted in schizophrenia 1 homolog (mouse) relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus [Term] id: PR:Q811T9-1 name: disrupted in schizophrenia 1 protein isoform 1 (mouse) def: "A disrupted in schizophrenia 1 protein isoform 1 that is encoded in the genome of mouse." [PMID:21471969, PRO:KRC] comment: Category=organism-sequence. synonym: "mDISC1/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q811T9-1 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000035601 ! disrupted in schizophrenia 1 protein isoform 1 [Term] id: PR:Q811T9-2 name: disrupted in schizophrenia 1 protein isoform 2 (mouse) def: "A disrupted in schizophrenia 1 homolog (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q811T9-2." [PMID:12506198, PRO:HJD] comment: Category=organism-sequence. synonym: "mDISC1/iso:2" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q811T9-2 is_a: PR:Q811T9 ! disrupted in schizophrenia 1 homolog (mouse) relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus [Term] id: PR:Q811T9-3 name: disrupted in schizophrenia 1 protein isoform 3 (mouse) def: "A disrupted in schizophrenia 1 homolog (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q811T9-3." [PMID:12504857, PRO:HJD] comment: Category=organism-sequence. synonym: "mDISC1/iso:3" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q811T9-3 is_a: PR:Q811T9 ! disrupted in schizophrenia 1 homolog (mouse) relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus [Term] id: PR:Q811T9 name: disrupted in schizophrenia 1 homolog (mouse) def: "A disrupted in schizophrenia 1 protein that is encoded in the genome of mouse." [OMA:Q811T9, PRO:DNx] comment: Category=organism-gene. synonym: "Disc1" RELATED Gene-based [UniProtKB:Q811T9] synonym: "mDISC1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q811T9 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000006494 ! disrupted in schizophrenia 1 protein relationship: has_gene_template MGI:2447658 ! Disc1 (mouse) [Term] id: PR:Q9NRI5-10 name: disrupted in schizophrenia 1 protein isoform h10 (human) def: "A disrupted in schizophrenia 1 protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NRI5-10." [PRO:DNx, UniProtKB:Q9NRI5] comment: Category=organism-sequence. synonym: "hDISC1/iso:h10" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q9NRI5-10 is_a: PR:Q9NRI5 ! disrupted in schizophrenia 1 protein (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q9NRI5-11 name: disrupted in schizophrenia 1 protein isoform h11 (human) def: "A disrupted in schizophrenia 1 protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NRI5-11." [PRO:DNx, UniProtKB:Q9NRI5] comment: Category=organism-sequence. synonym: "hDISC1/iso:h11" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q9NRI5-11 is_a: PR:Q9NRI5 ! disrupted in schizophrenia 1 protein (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000006494 name: disrupted in schizophrenia 1 protein def: "A protein that is a translation product of the human DISC1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "DISC1" EXACT PRO-short-label [PRO:DNx] synonym: "KIAA0457" RELATED Gene-based [] is_a: PR:000000001 ! protein [Term] id: PR:Q9NRI5-3 name: disrupted in schizophrenia 1 protein isoform h3 (human) def: "A disrupted in schizophrenia 1 protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NRI5-3." [PRO:DNx, UniProtKB:Q9NRI5] comment: Category=organism-sequence. synonym: "hDISC1/iso:h3" EXACT PRO-short-label [PRO:DNx] synonym: "disrupted in schizophrenia 1 protein isoform S (human)" EXACT [UniProtKB:Q9NRI5] xref: UniProtKB:Q9NRI5-3 is_a: PR:Q9NRI5 ! disrupted in schizophrenia 1 protein (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q810H6-2 name: disrupted in schizophrenia 1 homolog isoform r2 (rat) def: "A disrupted in schizophrenia 1 homolog (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q810H6-2." [PRO:DNx, UniProtKB:Q810H6] comment: Category=organism-sequence. synonym: "rDISC1/iso:r2" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q810H6-2 is_a: PR:Q810H6 ! disrupted in schizophrenia 1 homolog (rat) relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus [Term] id: PR:Q810H6-1 name: disrupted in schizophrenia 1 homolog isoform r1 (rat) def: "A disrupted in schizophrenia 1 homolog (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q810H6-1." [PRO:DNx, UniProtKB:Q810H6] comment: Category=organism-sequence. synonym: "rDISC1/iso:r1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q810H6-1 is_a: PR:Q810H6 ! disrupted in schizophrenia 1 homolog (rat) relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus [Term] id: PR:Q9NRI5-2 name: disrupted in schizophrenia 1 protein isoform h2 (human) def: "A disrupted in schizophrenia 1 protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NRI5-2." [PRO:DNx, UniProtKB:Q9NRI5] comment: Category=organism-sequence. synonym: "hDISC1/iso:h2" EXACT PRO-short-label [PRO:DNx] synonym: "disrupted in schizophrenia 1 protein isoform LV (human)" EXACT [UniProtKB:Q9NRI5] xref: UniProtKB:Q9NRI5-2 is_a: PR:Q9NRI5 ! disrupted in schizophrenia 1 protein (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q9NRI5 name: disrupted in schizophrenia 1 protein (human) def: "A disrupted in schizophrenia 1 protein that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9NRI5] comment: Category=organism-gene. synonym: "DISC1" RELATED Gene-based [UniProtKB:Q9NRI5] synonym: "hDISC1" EXACT PRO-short-label [PRO:DNx] synonym: "KIAA0457" RELATED Gene-based [UniProtKB:Q9NRI5] xref: UniProtKB:Q9NRI5 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000006494 ! disrupted in schizophrenia 1 protein relationship: has_gene_template HGNC:2888 ! DISC1 (human) [Term] id: PR:Q810H6 name: disrupted in schizophrenia 1 homolog (rat) def: "A disrupted in schizophrenia 1 protein that is encoded in the genome of rat." [OMA:Q810H6, PANTHER:PTHR14332:SF0, PRO:DNx] comment: Category=organism-gene. synonym: "Disc1" RELATED Gene-based [UniProtKB:Q810H6] synonym: "rDISC1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q810H6 intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus intersection_of: PR:000006494 ! disrupted in schizophrenia 1 protein relationship: has_gene_template RGD:631359 ! Disc1 (rat) [Term] id: PR:000035654 name: disrupted in schizophrenia 1 protein isoform 1 unphosphorylated form (mouse) def: "A disrupted in schizophrenia 1 protein isoform 1 unphosphorylated form in mouse." [PMID:21471969, PRO:KRC] comment: Category=organism-modification. synonym: "mDISC1/iso:1/PhosRes-" EXACT PRO-short-label [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000035653 ! disrupted in schizophrenia 1 protein isoform 1 unphosphorylated form [Term] id: PR:000035653 name: disrupted in schizophrenia 1 protein isoform 1 unphosphorylated form def: "A disrupted in schizophrenia 1 protein isoform 1 that lacks phosphorylated residues." [PRO:KRC] comment: Category=modification. synonym: "DISC1/iso:1/PhosRes-" EXACT PRO-short-label [PRO:DNx] intersection_of: lacks_part MOD:00696 ! phosphorylated residue intersection_of: PR:000035601 ! disrupted in schizophrenia 1 protein isoform 1