[Term]
id: PR:000006596
name: deoxyribonuclease-2-alpha
def: "A protein that is a translation product of the human DNASE2 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "DNL2" RELATED Gene-based []
synonym: "DNASE2" EXACT PRO-short-label [PRO:DNx]
synonym: "DNASE2A" RELATED Gene-based []
synonym: "R31240_2" EXACT []
synonym: "acid DNase" EXACT []
synonym: "DNase II alpha" EXACT []
synonym: "lysosomal DNase II" EXACT []
synonym: "deoxyribonuclease II alpha" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:O00115
name: deoxyribonuclease-2-alpha (human)
def: "A deoxyribonuclease-2-alpha that is encoded in the genome of human." [PRO:DNx, UniProtKB:O00115]
comment: Category=organism-gene.
synonym: "DNL2" RELATED Gene-based [UniProtKB:O00115]
synonym: "DNASE2" RELATED Gene-based [UniProtKB:O00115]
synonym: "DNASE2A" RELATED Gene-based [UniProtKB:O00115]
synonym: "hDNASE2" EXACT PRO-short-label [PRO:DNx]
synonym: "R31240_2 (human)" EXACT [UniProtKB:O00115]
synonym: "acid DNase (human)" EXACT [UniProtKB:O00115]
synonym: "DNase II alpha (human)" EXACT [UniProtKB:O00115]
synonym: "lysosomal DNase II (human)" EXACT [UniProtKB:O00115]
synonym: "deoxyribonuclease II alpha (human)" EXACT [UniProtKB:O00115]
xref: UniProtKB:O00115
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000006596 ! deoxyribonuclease-2-alpha
relationship: has_gene_template HGNC:2960 ! DNASE2 (human)

[Term]
id: PR:O62855
name: deoxyribonuclease-2-alpha (pig)
def: "A deoxyribonuclease-2-alpha that is encoded in the genome of pig." [OMA:O62855, PRO:DNx]
comment: Category=organism-gene. Requested by=PubChem.
synonym: "DNL2" RELATED Gene-based [UniProtKB:O62855]
synonym: "DNASE2" RELATED Gene-based [UniProtKB:O62855]
synonym: "DNASE2A" RELATED Gene-based [UniProtKB:O62855]
synonym: "pig-DNASE2" EXACT PRO-short-label [PRO:DNx]
synonym: "acid DNase (pig)" EXACT [UniProtKB:O62855]
synonym: "DNase II alpha (pig)" EXACT [UniProtKB:O62855]
synonym: "lysosomal DNase II (pig)" EXACT [UniProtKB:O62855]
synonym: "deoxyribonuclease II alpha (pig)" EXACT [UniProtKB:O62855]
xref: UniProtKB:O62855
intersection_of: only_in_taxon NCBITaxon:9823 ! Sus scrofa
intersection_of: PR:000006596 ! deoxyribonuclease-2-alpha
relationship: has_gene_template NCBIGene:397398 ! DNASE2 (pig)

[Term]
id: PR:O00115-2
name: deoxyribonuclease-2-alpha isoform h2 (human)
def: "A deoxyribonuclease-2-alpha (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O00115-2." [PRO:DNx, UniProtKB:O00115]
comment: Category=organism-sequence.
synonym: "hDNASE2/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O00115-2
is_a: PR:O00115 ! deoxyribonuclease-2-alpha (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000047201
name: deoxyribonuclease-2-alpha, signal peptide removed form (human)
def: "A deoxyribonuclease-2-alpha (human) that has had the signal peptide removed. UniProtKB:O00115, 19-360." [PRO:DNx, Reactome:R-HSA-429822, Reactome:R-HSA-434322]
comment: Category=organism-modification.
synonym: "PRO_0000007291" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hDNASE2/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O00115, 19-360" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-429822 "PR:000047201 located_in GO:0043202"
xref: Reactome:R-HSA-434322 "PR:000047201 located_in GO:0005796"
intersection_of: PR:O00115 ! deoxyribonuclease-2-alpha (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P56542
name: deoxyribonuclease-2-alpha (mouse)
def: "A deoxyribonuclease-2-alpha that is encoded in the genome of mouse." [OMA:P56542, PRO:DNx]
comment: Category=organism-gene.
synonym: "Dnl2" RELATED Gene-based [UniProtKB:P56542]
synonym: "Dnase2" RELATED Gene-based [UniProtKB:P56542]
synonym: "Dnase2a" RELATED Gene-based [UniProtKB:P56542]
synonym: "mDNASE2" EXACT PRO-short-label [PRO:DNx]
synonym: "acid DNase (mouse)" EXACT [UniProtKB:P56542]
synonym: "DNase II alpha (mouse)" EXACT [UniProtKB:P56542]
synonym: "lysosomal DNase II (mouse)" EXACT [UniProtKB:P56542]
synonym: "deoxyribonuclease II alpha (mouse)" EXACT [UniProtKB:P56542]
xref: UniProtKB:P56542
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000006596 ! deoxyribonuclease-2-alpha
relationship: has_gene_template MGI:1329019 ! Dnase2a (mouse)

[Term]
id: PR:O00115-1
name: deoxyribonuclease-2-alpha isoform h1 (human)
def: "A deoxyribonuclease-2-alpha (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O00115-1." [PRO:DNx, UniProtKB:O00115]
comment: Category=organism-sequence.
synonym: "hDNASE2/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O00115-1
is_a: PR:O00115 ! deoxyribonuclease-2-alpha (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9QZK8
name: deoxyribonuclease-2-alpha (rat)
def: "A deoxyribonuclease-2-alpha that is encoded in the genome of rat." [OMA:Q9QZK8, PANTHER:PTHR10858:SF9, PRO:DNx]
comment: Category=organism-gene.
synonym: "Dnl2" RELATED Gene-based [UniProtKB:Q9QZK8]
synonym: "Dnase2" RELATED Gene-based [UniProtKB:Q9QZK8]
synonym: "Dnase2a" RELATED Gene-based [UniProtKB:Q9QZK8]
synonym: "rDNASE2" EXACT PRO-short-label [PRO:DNx]
synonym: "acid DNase (rat)" EXACT [UniProtKB:Q9QZK8]
synonym: "DNase II alpha (rat)" EXACT [UniProtKB:Q9QZK8]
synonym: "lysosomal DNase II (rat)" EXACT [UniProtKB:Q9QZK8]
synonym: "deoxyribonuclease II alpha (rat)" EXACT [UniProtKB:Q9QZK8]
xref: UniProtKB:Q9QZK8
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000006596 ! deoxyribonuclease-2-alpha
relationship: has_gene_template RGD:621457 ! Dnase2 (rat)

[Term]
id: PR:P34387
name: cell-death-related nuclease 7 (worm)
def: "A deoxyribonuclease-2-alpha that is encoded in the genome of worm." [PRO:DNx]
comment: Category=organism-gene.
synonym: "crn-7" RELATED Gene-based [UniProtKB:P34387]
synonym: "F09G8.2" RELATED Gene-based [UniProtKB:P34387]
synonym: "tag-198" RELATED Gene-based [UniProtKB:P34387]
synonym: "DNASE2 (worm)" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P34387
intersection_of: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans
intersection_of: PR:000006596 ! deoxyribonuclease-2-alpha
relationship: has_gene_template WormBase:WBGene00007056 ! crn-7 (worm)