[Term]
id: PR:000006959
name: interferon-induced, double-stranded RNA-activated protein kinase
def: "A protein that is a translation product of the human EIF2AK2 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "PKR" RELATED Gene-based []
synonym: "Tik" RELATED Gene-based []
synonym: "PRKR" RELATED Gene-based []
synonym: "EIF2AK2" EXACT PRO-short-label [PRO:DNx]
synonym: "p68 kinase" EXACT []
synonym: "protein kinase R" EXACT []
synonym: "eIF-2A protein kinase 2" EXACT []
synonym: "P1/eIF-2A protein kinase" EXACT []
synonym: "protein kinase RNA-activated" EXACT []
synonym: "tyrosine-protein kinase EIF2AK2" EXACT []
synonym: "serine/threonine-protein kinase TIK" EXACT []
synonym: "interferon-inducible RNA-dependent protein kinase" EXACT []
synonym: "eukaryotic translation initiation factor 2-alpha kinase 2" EXACT []
xref: IUPHARobj:2016
is_a: PR:000000001 ! protein

[Term]
id: PR:000047263
name: interferon-induced, double-stranded RNA-activated protein kinase, initiator methionine removed form (human)
def: "An interferon-induced, double-stranded RNA-activated protein kinase (human) that has had the initiator methionine removed. UniProtKB:P19525, 2-551." [PRO:DNx, Reactome:R-HSA-168699]
comment: Category=organism-modification.
synonym: "PRO_0000085945" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hEIF2AK2/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P19525, 2-551" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-168699 "PR:000047263 located_in GO:0005829"
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:P19525 ! interferon-induced, double-stranded RNA-activated protein kinase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000045703
name: interferon-induced, double-stranded RNA-activated protein kinase phosphorylated 1 (human)
def: "An interferon-induced, double-stranded RNA-activated protein kinase (human) that has been phosphorylated on the residue at the position equivalent to Thr-451 of the amino acid sequence represented by UniProtKB:P19525-1. Example: UniProtKB:P19525-1, Thr-451, MOD:00047." [PMID:17404396, iPTMnet:P19525]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:17404396). Status=unreviewed.
synonym: "hEIF2AK2/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P19525-1, Thr-451, MOD:00047" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P19525 ! interferon-induced, double-stranded RNA-activated protein kinase (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P19525
name: interferon-induced, double-stranded RNA-activated protein kinase (human)
def: "An interferon-induced, double-stranded RNA-activated protein kinase that is encoded in the genome of human." [PRO:DNx, UniProtKB:P19525]
comment: Category=organism-gene.
synonym: "PKR" RELATED Gene-based [UniProtKB:P19525]
synonym: "PRKR" RELATED Gene-based [UniProtKB:P19525]
synonym: "EIF2AK2" RELATED Gene-based [UniProtKB:P19525]
synonym: "hEIF2AK2" EXACT PRO-short-label [PRO:DNx]
synonym: "p68 kinase (human)" EXACT [UniProtKB:P19525]
synonym: "protein kinase R (human)" EXACT [UniProtKB:P19525]
synonym: "eIF-2A protein kinase 2 (human)" EXACT [UniProtKB:P19525]
synonym: "P1/eIF-2A protein kinase (human)" EXACT [UniProtKB:P19525]
synonym: "protein kinase RNA-activated (human)" EXACT [UniProtKB:P19525]
synonym: "tyrosine-protein kinase EIF2AK2 (human)" EXACT [UniProtKB:P19525]
synonym: "interferon-inducible RNA-dependent protein kinase (human)" EXACT [UniProtKB:P19525]
synonym: "eukaryotic translation initiation factor 2-alpha kinase 2 (human)" EXACT [UniProtKB:P19525]
xref: DTO:03100119
xref: UniProtKB:P19525
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000006959 ! interferon-induced, double-stranded RNA-activated protein kinase
relationship: has_gene_template HGNC:9437 ! EIF2AK2 (human)

[Term]
id: PR:P19525-1
name: interferon-induced, double-stranded RNA-activated protein kinase isoform 1 (human)
def: "An interferon-induced, double-stranded RNA-activated protein kinase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P19525-1." [PRO:DNx, UniProtKB:P19525]
comment: Category=organism-sequence. Requested by=PubChem.
synonym: "hEIF2AK2/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P19525-1
is_a: PR:P19525 ! interferon-induced, double-stranded RNA-activated protein kinase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P19525-2
name: interferon-induced, double-stranded RNA-activated protein kinase isoform h2 (human)
def: "An interferon-induced, double-stranded RNA-activated protein kinase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P19525-2." [PRO:DNx, UniProtKB:P19525]
comment: Category=organism-sequence.
synonym: "hEIF2AK2/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P19525-2
is_a: PR:P19525 ! interferon-induced, double-stranded RNA-activated protein kinase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens