[Term]
id: PR:000047264
name: eukaryotic translation initiation factor 2-alpha kinase 3, signal peptide removed form (human)
def: "A eukaryotic translation initiation factor 2-alpha kinase 3 (human) that has had the signal peptide removed. UniProtKB:Q9NZJ5, 30-1116." [PRO:DNx, Reactome:R-HSA-381046]
comment: Category=organism-modification.
synonym: "PRO_0000024322" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hEIF2AK3/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q9NZJ5, 30-1116" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-381046 "PR:000047264 located_in GO:0005789"
intersection_of: PR:Q9NZJ5 ! eukaryotic translation initiation factor 2-alpha kinase 3 (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9NIV1
name: eukaryotic translation initiation factor 2-alpha kinase (fruit fly)
def: "A eukaryotic translation initiation factor 2-alpha kinase 3 that is encoded in the genome of fruit fly." [OMA:Q9NIV1, PRO:DNx]
comment: Category=organism-gene.
synonym: "PEK" RELATED Gene-based [UniProtKB:Q9NIV1]
synonym: "DmPEK" EXACT [UniProtKB:Q9NIV1]
synonym: "CG2087" RELATED Gene-based [UniProtKB:Q9NIV1]
synonym: "EIF2AK3" RELATED Gene-based [UniProtKB:Q9NIV1]
synonym: "fly-EIF2AK3" EXACT PRO-short-label [PRO:DNx]
synonym: "PERK (fruit fly)" EXACT [UniProtKB:Q9NIV1]
synonym: "PRKR-like endoplasmic reticulum kinase (fruit fly)" EXACT [UniProtKB:Q9NIV1]
xref: UniProtKB:Q9NIV1
intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster
intersection_of: PR:000006960 ! eukaryotic translation initiation factor 2-alpha kinase 3
relationship: has_gene_template FlyBase:FBgn0037327 ! PEK (fruit fly)

[Term]
id: PR:000006960
name: eukaryotic translation initiation factor 2-alpha kinase 3
def: "A protein that is a translation product of the human EIF2AK3 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "PEK" RELATED Gene-based []
synonym: "PERK" RELATED Gene-based []
synonym: "EIF2AK3" EXACT PRO-short-label [PRO:DNx]
synonym: "pancreatic eIF2-alpha kinase" EXACT []
synonym: "PRKR-like endoplasmic reticulum kinase" EXACT []
xref: IUPHARobj:2017
is_a: PR:000000001 ! protein

[Term]
id: PR:Q19192
name: eukaryotic translation initiation factor 2-alpha kinase pek-1 (worm)
def: "A eukaryotic translation initiation factor 2-alpha kinase 3 that is encoded in the genome of worm." [OMA:Q19192, PRO:DNx]
comment: Category=organism-gene.
synonym: "CePEK" EXACT [UniProtKB:Q19192]
synonym: "pek-1" RELATED Gene-based [UniProtKB:Q19192]
synonym: "F46C3.1" RELATED Gene-based [UniProtKB:Q19192]
synonym: "PEK (worm)" EXACT [UniProtKB:Q19192]
synonym: "PERK (worm)" EXACT [UniProtKB:Q19192]
synonym: "EIF2AK3 (worm)" EXACT PRO-short-label [PRO:DNx]
synonym: "PRKR-like endoplasmic reticulum kinase (worm)" EXACT [UniProtKB:Q19192]
xref: UniProtKB:Q19192
intersection_of: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans
intersection_of: PR:000006960 ! eukaryotic translation initiation factor 2-alpha kinase 3
relationship: has_gene_template WormBase:WBGene00003970 ! pek-1 (worm)

[Term]
id: PR:Q9Z1Z1
name: eukaryotic translation initiation factor 2-alpha kinase 3 (rat)
def: "A eukaryotic translation initiation factor 2-alpha kinase 3 that is encoded in the genome of rat." [OMA:Q9Z1Z1, PANTHER:PTHR11042:SF15, PRO:DNx]
comment: Category=organism-gene.
synonym: "Pek" RELATED Gene-based [UniProtKB:Q9Z1Z1]
synonym: "Perk" RELATED Gene-based [UniProtKB:Q9Z1Z1]
synonym: "Eif2ak3" RELATED Gene-based [UniProtKB:Q9Z1Z1]
synonym: "rEIF2AK3" EXACT PRO-short-label [PRO:DNx]
synonym: "pancreatic eIF2-alpha kinase (rat)" EXACT [UniProtKB:Q9Z1Z1]
synonym: "PRKR-like endoplasmic reticulum kinase (rat)" EXACT [UniProtKB:Q9Z1Z1]
xref: UniProtKB:Q9Z1Z1
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000006960 ! eukaryotic translation initiation factor 2-alpha kinase 3
relationship: has_gene_template RGD:70884 ! Eif2ak3 (rat)

[Term]
id: PR:Q9NZJ5
name: eukaryotic translation initiation factor 2-alpha kinase 3 (human)
def: "A eukaryotic translation initiation factor 2-alpha kinase 3 that is encoded in the genome of human." [PRO:CNx, UniProtKB:Q9NZJ5]
comment: Category=organism-gene. Requested by=PubChem.
synonym: "PEK" RELATED Gene-based [UniProtKB:Q9NZJ5]
synonym: "PERK" RELATED Gene-based [UniProtKB:Q9NZJ5]
synonym: "HsPEK" EXACT [UniProtKB:Q9NZJ5]
synonym: "EIF2AK3" RELATED Gene-based [UniProtKB:Q9NZJ5]
synonym: "hEIF2AK3" EXACT PRO-short-label [PRO:DNx]
synonym: "pancreatic eIF2-alpha kinase (human)" EXACT [UniProtKB:Q9NZJ5]
synonym: "PRKR-like endoplasmic reticulum kinase (human)" EXACT [UniProtKB:Q9NZJ5]
xref: DTO:03100120
xref: UniProtKB:Q9NZJ5
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000006960 ! eukaryotic translation initiation factor 2-alpha kinase 3
relationship: has_gene_template HGNC:3255 ! EIF2AK3 (human)

[Term]
id: PR:Q9Z2B5
name: eukaryotic translation initiation factor 2-alpha kinase 3 (mouse)
def: "A eukaryotic translation initiation factor 2-alpha kinase 3 that is encoded in the genome of mouse." [OMA:Q9Z2B5, PRO:DNx]
comment: Category=organism-gene.
synonym: "Pek" RELATED Gene-based [UniProtKB:Q9Z2B5]
synonym: "Perk" RELATED Gene-based [UniProtKB:Q9Z2B5]
synonym: "Eif2ak3" RELATED Gene-based [UniProtKB:Q9Z2B5]
synonym: "mEIF2AK3" EXACT PRO-short-label [PRO:DNx]
synonym: "pancreatic eIF2-alpha kinase (mouse)" EXACT [UniProtKB:Q9Z2B5]
synonym: "PRKR-like endoplasmic reticulum kinase (mouse)" EXACT [UniProtKB:Q9Z2B5]
xref: UniProtKB:Q9Z2B5
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000006960 ! eukaryotic translation initiation factor 2-alpha kinase 3
relationship: has_gene_template MGI:1341830 ! Eif2ak3 (mouse)