[Term]
id: PR:000006990
name: eukaryotic translation initiation factor 4E
def: "A protein that is a translation product of the human EIF4E gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "EIF4E" EXACT PRO-short-label [PRO:DNx]
synonym: "EIF4F" RELATED Gene-based []
synonym: "eIF4E" EXACT []
synonym: "eIF-4E" EXACT []
synonym: "EIF4EL1" RELATED Gene-based []
synonym: "eIF-4F 25 kDa subunit" EXACT []
synonym: "mRNA cap-binding protein" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:P06730-1
name: eukaryotic translation initiation factor 4E isoform 1 (human)
def: "A eukaryotic translation initiation factor 4E isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hEIF4E/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P06730-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000038694 ! eukaryotic translation initiation factor 4E isoform 1

[Term]
id: PR:P06730-2
name: eukaryotic translation initiation factor 4E isoform h2 (human)
def: "A eukaryotic translation initiation factor 4E (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P06730-2." [PRO:DNx, UniProtKB:P06730]
comment: Category=organism-sequence.
synonym: "hEIF4E/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P06730-2
is_a: PR:P06730 ! eukaryotic translation initiation factor 4E (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P06730-3
name: eukaryotic translation initiation factor 4E isoform h3 (human)
def: "A eukaryotic translation initiation factor 4E (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P06730-3." [PRO:DNx, UniProtKB:P06730]
comment: Category=organism-sequence.
synonym: "hEIF4E/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P06730-3
is_a: PR:P06730 ! eukaryotic translation initiation factor 4E (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000045646
name: eukaryotic translation initiation factor 4E phosphorylated 1 (human)
def: "A eukaryotic translation initiation factor 4E (human) that has been phosphorylated on the residue at the position equivalent to Ser-53 of the amino acid sequence represented by UniProtKB:P06730-1. Example: UniProtKB:P06730-1, Ser-53, MOD:00046." [PMID:3112145, iPTMnet:P06730]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:3112145). Status=unreviewed.
synonym: "hEIF4E/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P06730-1, Ser-53, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P06730 ! eukaryotic translation initiation factor 4E (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P06730
name: eukaryotic translation initiation factor 4E (human)
def: "A eukaryotic translation initiation factor 4E that is encoded in the genome of human." [PRO:DNx, UniProtKB:P06730]
comment: Category=organism-gene.
synonym: "EIF4E" RELATED Gene-based [UniProtKB:P06730]
synonym: "EIF4F" RELATED Gene-based [UniProtKB:P06730]
synonym: "hEIF4E" EXACT PRO-short-label [PRO:DNx]
synonym: "EIF4EL1" RELATED Gene-based [UniProtKB:P06730]
synonym: "eIF4E (human)" EXACT [UniProtKB:P06730]
synonym: "eIF-4E (human)" EXACT [UniProtKB:P06730]
synonym: "eIF-4F 25 kDa subunit (human)" EXACT [UniProtKB:P06730]
synonym: "mRNA cap-binding protein (human)" EXACT [UniProtKB:P06730]
xref: UniProtKB:P06730
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000006990 ! eukaryotic translation initiation factor 4E
relationship: has_gene_template HGNC:3287 ! EIF4E (human)

[Term]
id: PR:000028426
name: eukaryotic translation initiation factor 4E, initiator methionine removed form (human)
def: "A eukaryotic translation initiation factor 4E, initiator methionine removed form in human. Example: UniProtKB:P06730-1, 2-217." [PRO:DNx]
comment: Category=organism-modification.
synonym: "PRO_0000193634" NARROW PRO-proteoform-ftid [PRO:DNx]
synonym: "hEIF4E/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P06730-1, 2-217" NARROW PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-72578 "PR:000028426 located_in GO:0005829"
xref: TDR:1950
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000019768 ! eukaryotic translation initiation factor 4E, initiator methionine removed form