[Term] id: PR:Q15910-3 name: histone-lysine N-methyltransferase EZH2 isoform h3 (human) def: "A histone-lysine N-methyltransferase EZH2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15910-3." [PRO:DNx, UniProtKB:Q15910] comment: Category=organism-sequence. synonym: "hEZH2/iso:h3" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q15910-3 is_a: PR:Q15910 ! histone-lysine N-methyltransferase EZH2 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q08BS4 name: histone-lysine N-methyltransferase EZH2 (zebrafish) def: "A histone-lysine N-methyltransferase EZH2 that is encoded in the genome of zebrafish." [PANTHER:PTHR22884:SF18, PRO:DNx] comment: Category=organism-gene. synonym: "ezh2" RELATED Gene-based [UniProtKB:Q08BS4] synonym: "z-EZH2" EXACT PRO-short-label [PRO:DNx] synonym: "zgc:152758" RELATED Gene-based [UniProtKB:Q08BS4] synonym: "enhancer of zeste homolog 2 (zebrafish)" EXACT [UniProtKB:Q08BS4] xref: UniProtKB:Q08BS4 intersection_of: only_in_taxon NCBITaxon:7955 ! Danio rerio intersection_of: PR:000007278 ! histone-lysine N-methyltransferase EZH2 relationship: has_gene_template ZFIN:ZDB-GENE-041111-259 ! ezh2 (zebrafish) [Term] id: PR:Q15910-1 name: histone-lysine N-methyltransferase EZH2 isoform 1 (human) def: "A histone-lysine N-methyltransferase EZH2 isoform 1 that is encoded in the genome of human." [PRO:DNx] comment: Category=organism-sequence. synonym: "hEZH2/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q15910-1 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000040685 ! histone-lysine N-methyltransferase EZH2 isoform 1 [Term] id: PR:Q61188-2 name: histone-lysine N-methyltransferase EZH2 isoform mENX-1B (mouse) def: "A histone-lysine N-methyltransferase EZH2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q61188-2." [PRO:DNx, UniProtKB:Q61188] comment: Category=organism-sequence. synonym: "mEZH2/iso:mENX-1B" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q61188-2 is_a: PR:Q61188 ! histone-lysine N-methyltransferase EZH2 (mouse) relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus [Term] id: PR:Q15910-5 name: histone-lysine N-methyltransferase EZH2 isoform h5 (human) def: "A histone-lysine N-methyltransferase EZH2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15910-5." [PRO:DNx, UniProtKB:Q15910] comment: Category=organism-sequence. synonym: "hEZH2/iso:h5" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q15910-5 is_a: PR:Q15910 ! histone-lysine N-methyltransferase EZH2 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q15910-2 name: histone-lysine N-methyltransferase EZH2 isoform h2 (human) def: "A histone-lysine N-methyltransferase EZH2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15910-2." [PRO:DNx, UniProtKB:Q15910] comment: Category=organism-sequence. synonym: "hEZH2/iso:h2" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q15910-2 is_a: PR:Q15910 ! histone-lysine N-methyltransferase EZH2 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000045949 name: histone-lysine N-methyltransferase EZH2 phosphorylated 1 (human) def: "A histone-lysine N-methyltransferase EZH2 (human) that has been phosphorylated on the residue at the position equivalent to Thr-416 of the amino acid sequence represented by UniProtKB:Q15910-1. Example: UniProtKB:Q15910-1, Thr-416, MOD:00047." [PMID:23241245, PMID:26279746, iPTMnet:Q15910] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:23241245, PMID:26279746). Status=unreviewed. synonym: "hEZH2/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q15910-1, Thr-416, MOD:00047" NARROW PRO-proteoform-std [PRO:DNx] is_a: PR:Q15910 ! histone-lysine N-methyltransferase EZH2 (human) relationship: has_part MOD:00047 ! O-phospho-L-threonine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000040685 name: histone-lysine N-methyltransferase EZH2 isoform 1 def: "A histone-lysine N-methyltransferase EZH2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15910-1 or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=sequence. synonym: "EZH2/iso:1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000007278 ! histone-lysine N-methyltransferase EZH2 [Term] id: PR:Q61188-1 name: histone-lysine N-methyltransferase EZH2 isoform ENX-1A (mouse) def: "A histone-lysine N-methyltransferase EZH2 isoform 1 that is encoded in the genome of mouse." [PRO:DNx] comment: Category=organism-sequence. synonym: "mEZH2/iso:ENX-1A" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q61188-1 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000040685 ! histone-lysine N-methyltransferase EZH2 isoform 1 [Term] id: PR:000007278 name: histone-lysine N-methyltransferase EZH2 def: "A protein that is a translation product of the human EZH2 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "EZH2" EXACT PRO-short-label [PRO:DNx] synonym: "KMT6" RELATED Gene-based [] synonym: "ENX-1" EXACT [] synonym: "Enx1h" RELATED Gene-based [] synonym: "enhancer of zeste homolog 2" EXACT [] synonym: "lysine N-methyltransferase 6" EXACT [] xref: IUPHARobj:2654 is_a: PR:000000001 ! protein [Term] id: PR:P42124 name: histone-lysine N-methyltransferase E(z) (fruit fly) def: "A histone-lysine N-methyltransferase EZH2 that is encoded in the genome of fruit fly." [PRO:DNx] comment: Category=organism-gene. synonym: "E(z)" RELATED Gene-based [UniProtKB:P42124] synonym: "KMT6" RELATED Gene-based [UniProtKB:P42124] synonym: "CG6502" RELATED Gene-based [UniProtKB:P42124] synonym: "fly-EZH2" EXACT PRO-short-label [PRO:DNx] synonym: "protein enhancer of zeste (fruit fly)" EXACT [UniProtKB:P42124] synonym: "lysine N-methyltransferase 6 (fruit fly)" EXACT [UniProtKB:P42124] xref: UniProtKB:P42124 intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster intersection_of: PR:000007278 ! histone-lysine N-methyltransferase EZH2 relationship: has_gene_template FlyBase:FBgn0000629 ! E(z) (fruit fly) [Term] id: PR:Q6AXH7 name: histone-lysine N-methyltransferase EZH2 isoform Q6AXH7 (mouse) def: "A histone-lysine N-methyltransferase EZH2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6AXH7." [PMID:23624931, PRO:DNx, PRO:HJD, UniProtKB:Q6AXH7] comment: Category=organism-sequence. synonym: "mEZH2/iso:Q6AXH7" EXACT PRO-short-label [PRO:DAN] xref: UniProtKB:Q6AXH7 is_a: PR:Q61188 ! histone-lysine N-methyltransferase EZH2 (mouse) relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus [Term] id: PR:Q61188 name: histone-lysine N-methyltransferase EZH2 (mouse) def: "A histone-lysine N-methyltransferase EZH2 that is encoded in the genome of mouse." [OMA:Q61188, PRO:DNx] comment: Category=organism-gene. synonym: "Ezh2" RELATED Gene-based [UniProtKB:Q61188] synonym: "Enx1h" RELATED Gene-based [UniProtKB:Q61188] synonym: "mEZH2" EXACT PRO-short-label [PRO:DNx] synonym: "ENX-1 (mouse)" EXACT [UniProtKB:Q61188] synonym: "enhancer of zeste homolog 2 (mouse)" EXACT [UniProtKB:Q61188] xref: UniProtKB:Q61188 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000007278 ! histone-lysine N-methyltransferase EZH2 relationship: has_gene_template MGI:107940 ! Ezh2 (mouse) [Term] id: PR:Q15910-4 name: histone-lysine N-methyltransferase EZH2 isoform h4 (human) def: "A histone-lysine N-methyltransferase EZH2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15910-4." [PRO:DNx, UniProtKB:Q15910] comment: Category=organism-sequence. synonym: "hEZH2/iso:h4" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q15910-4 is_a: PR:Q15910 ! histone-lysine N-methyltransferase EZH2 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q15910 name: histone-lysine N-methyltransferase EZH2 (human) def: "A histone-lysine N-methyltransferase EZH2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q15910] comment: Category=organism-gene. synonym: "EZH2" RELATED Gene-based [UniProtKB:Q15910] synonym: "KMT6" RELATED Gene-based [UniProtKB:Q15910] synonym: "hEZH2" EXACT PRO-short-label [PRO:DNx] synonym: "ENX-1 (human)" EXACT [UniProtKB:Q15910] synonym: "enhancer of zeste homolog 2 (human)" EXACT [UniProtKB:Q15910] synonym: "lysine N-methyltransferase 6 (human)" EXACT [UniProtKB:Q15910] xref: Reactome:R-HSA-212298 "PR:Q15910 located_in GO:0005654" xref: UniProtKB:Q15910 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000007278 ! histone-lysine N-methyltransferase EZH2 relationship: has_gene_template HGNC:3527 ! EZH2 (human)