[Term] id: PR:P00451-2 name: coagulation factor VIII isoform h2 (human) def: "A coagulation factor VIII (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P00451-2." [PRO:DNx, UniProtKB:P00451] comment: Category=organism-sequence. synonym: "hF8/iso:h2" EXACT PRO-short-label [PRO:DNx] synonym: "coagulation factor VIII isoform F8B (human)" EXACT [UniProtKB:P00451] xref: UniProtKB:P00451-2 is_a: PR:P00451 ! coagulation factor VIII (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P00451-1 name: coagulation factor VIII isoform h1 (human) def: "A coagulation factor VIII (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P00451-1." [PRO:DNx, UniProtKB:P00451] comment: Category=organism-sequence. synonym: "hF8/iso:h1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P00451-1 is_a: PR:P00451 ! coagulation factor VIII (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P00451 name: coagulation factor VIII (human) def: "A coagulation factor VIII that is encoded in the genome of human." [PRO:DNx, UniProtKB:P00451] comment: Category=organism-gene. synonym: "F8" RELATED Gene-based [UniProtKB:P00451] synonym: "F8C" RELATED Gene-based [UniProtKB:P00451] synonym: "hF8" EXACT PRO-short-label [PRO:DNx] synonym: "AHF (human)" EXACT [UniProtKB:P00451] synonym: "antihemophilic factor (human)" EXACT [UniProtKB:P00451] synonym: "procoagulant component (human)" EXACT [UniProtKB:P00451] xref: UniProtKB:P00451 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000007302 ! coagulation factor VIII relationship: has_gene_template HGNC:3546 ! F8 (human) [Term] id: PR:000051024 name: coagulation factor VIII O-glycosylated 1 (human) def: "A coagulation factor VIII (human) that has been O-glycosylated at the residue equivalent to Ser-1396 of the amino acid sequence represented by UniProtKB:P00451-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:P00451-1, Ser-1396, MOD:00002~GNO:G29068FM." [GlyGen:P00451-1, PMID:30459171, PRO:DNx] comment: Category=organism-modification. Requested by=GlyGen. synonym: "hF8/OGlyco:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P00451-1, Ser-1396, MOD:00002~GNO:G29068FM" NARROW PRO-proteoform-std [PRO:DNx] is_a: PR:P00451 ! coagulation factor VIII (human) relationship: has_part GNO:G29068FM ! G29068FM relationship: has_part MOD:00002 ! O-glycosyl-L-serine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000051025 name: coagulation factor VIII O-glycosylated 2 (human) def: "A coagulation factor VIII (human) that has been O-glycosylated at the residue equivalent to Thr-818 of the amino acid sequence represented by UniProtKB:P00451-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P00451-1, Thr-818, MOD:00005~GNO:G43417UB." [GlyGen:P00451-1, PMID:30459171, PRO:DNx] comment: Category=organism-modification. Requested by=GlyGen. synonym: "hF8/OGlyco:2" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P00451-1, Thr-818, MOD:00005~GNO:G43417UB" NARROW PRO-proteoform-std [PRO:DNx] is_a: PR:P00451 ! coagulation factor VIII (human) relationship: has_part GNO:G43417UB ! G43417UB relationship: has_part MOD:00005 ! O-glycosyl-L-threonine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000051026 name: coagulation factor VIII O-glycosylated 3 (human) def: "A coagulation factor VIII (human) that has been O-glycosylated at the residue equivalent to Thr-869 of the amino acid sequence represented by UniProtKB:P00451-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P00451-1, Thr-869, MOD:00005~GNO:G43417UB." [GlyGen:P00451-1, PMID:30459171, PRO:DNx] comment: Category=organism-modification. Requested by=GlyGen. synonym: "hF8/OGlyco:3" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P00451-1, Thr-869, MOD:00005~GNO:G43417UB" NARROW PRO-proteoform-std [PRO:DNx] is_a: PR:P00451 ! coagulation factor VIII (human) relationship: has_part GNO:G43417UB ! G43417UB relationship: has_part MOD:00005 ! O-glycosyl-L-threonine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000007302 name: coagulation factor VIII def: "A protein that is a translation product of the human F8 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "F8" EXACT PRO-short-label [PRO:DNx] synonym: "AHF" EXACT [] synonym: "Cf8" RELATED Gene-based [] synonym: "F8C" RELATED Gene-based [] synonym: "antihemophilic factor" EXACT [] synonym: "procoagulant component" EXACT [] xref: IUPHARobj:2607 is_a: PR:000000001 ! protein [Term] id: PR:000047356 name: coagulation factor VIII, signal peptide removed form (human) def: "A coagulation factor VIII (human) that has had the signal peptide removed. UniProtKB:P00451, 20-2351." [PRO:DNx, Reactome:R-HSA-114591, Reactome:R-HSA-54601, Reactome:R-HSA-5689449, Reactome:R-HSA-5689796, Reactome:R-HSA-5689798] comment: Category=organism-modification. synonym: "hF8/SigPep-" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000002967" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:P00451, 20-2351" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-114591 "PR:000047356 located_in GO:0031093" xref: Reactome:R-HSA-54601 "PR:000047356 located_in GO:0005576" xref: Reactome:R-HSA-5689449 "PR:000047356 located_in GO:0005788" xref: Reactome:R-HSA-5689796 "PR:000047356 located_in GO:0030134" xref: Reactome:R-HSA-5689798 "PR:000047356 located_in GO:0033116" intersection_of: PR:P00451 ! coagulation factor VIII (human) intersection_of: lacks_part SO:0000418 ! signal_peptide relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens