[Term]
id: PR:000007427
name: F-box/WD repeat-containing protein 7
def: "A protein that is a translation product of the human FBXW7 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "Ago" EXACT []
synonym: "Cdc4" EXACT []
synonym: "FBW7" RELATED Gene-based []
synonym: "FBX30" RELATED Gene-based []
synonym: "FBXW7" EXACT PRO-short-label [PRO:DNx]
synonym: "Fbwd6" RELATED Gene-based []
synonym: "Fbxw6" RELATED Gene-based []
synonym: "SEL10" RELATED Gene-based []
synonym: "SEL-10" EXACT []
synonym: "F-box protein FBW7" EXACT []
synonym: "F-box protein FBX30" RELATED []
synonym: "F-box protein Fbxw6" EXACT []
synonym: "archipelago homolog" EXACT []
synonym: "F-box-WD40 repeat protein 6" EXACT []
synonym: "F-box and WD-40 domain-containing protein 7" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:Q969H0
name: F-box/WD repeat-containing protein 7 (human)
def: "An F-box/WD repeat-containing protein 7 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q969H0]
comment: Category=organism-gene.
synonym: "FBW7" RELATED Gene-based [UniProtKB:Q969H0]
synonym: "hAgo" EXACT [UniProtKB:Q969H0]
synonym: "FBX30" RELATED Gene-based [UniProtKB:Q969H0]
synonym: "FBXW7" RELATED Gene-based [UniProtKB:Q969H0]
synonym: "SEL10" RELATED Gene-based [UniProtKB:Q969H0]
synonym: "hCdc4" EXACT [UniProtKB:Q969H0]
synonym: "hFBXW7" EXACT PRO-short-label [PRO:DNx]
synonym: "SEL-10 (human)" EXACT [UniProtKB:Q969H0]
synonym: "F-box protein FBX30 (human)" BROAD [UniProtKB:Q969H0]
synonym: "archipelago homolog (human)" EXACT [UniProtKB:Q969H0]
synonym: "F-box and WD-40 domain-containing protein 7 (human)" EXACT [UniProtKB:Q969H0]
xref: Reactome:R-HSA-391304 "PR:Q969H0 located_in GO:0005829"
xref: UniProtKB:Q969H0
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000007427 ! F-box/WD repeat-containing protein 7
relationship: has_gene_template HGNC:16712 ! FBXW7 (human)

[Term]
id: PR:000046017
name: F-box/WD repeat-containing protein 7 phosphorylated 1 (human)
def: "An F-box/WD repeat-containing protein 7 (human) that has been phosphorylated on the residue at the position equivalent to Ser-227 of the amino acid sequence represented by UniProtKB:Q969H0-1. Example: UniProtKB:Q969H0-1, Ser-227, MOD:00046." [PMID:21147854, iPTMnet:Q969H0]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:21147854). Status=unreviewed.
synonym: "hFBXW7/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q969H0-1, Ser-227, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:Q969H0 ! F-box/WD repeat-containing protein 7 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q969H0-4
name: F-box/WD repeat-containing protein 7 isoform h3 (human)
def: "An F-box/WD repeat-containing protein 7 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q969H0-4." [PRO:DNx, UniProtKB:Q969H0]
comment: Category=organism-sequence.
synonym: "hFBXW7/iso:h3" EXACT PRO-short-label [PRO:DNx]
synonym: "F-box/WD repeat-containing protein 7 isoform FBW7gamma (human)" EXACT [UniProtKB:Q969H0]
synonym: "F-box/WD repeat-containing protein 7 isoform Hippocampal (human)" EXACT [UniProtKB:Q969H0]
synonym: "F-box/WD repeat-containing protein 7 isoform Archipelago gamma (human)" EXACT [UniProtKB:Q969H0]
xref: Reactome:R-HSA-1602297 "PR:Q969H0-4 located_in GO:0005654"
xref: UniProtKB:Q969H0-4
is_a: PR:Q969H0 ! F-box/WD repeat-containing protein 7 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q969H0-1
name: F-box/WD repeat-containing protein 7 isoform h1 (human)
def: "An F-box/WD repeat-containing protein 7 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q969H0-1." [PRO:DNx, UniProtKB:Q969H0]
comment: Category=organism-sequence.
synonym: "hFBXW7/iso:h1" EXACT PRO-short-label [PRO:DNx]
synonym: "F-box/WD repeat-containing protein 7 isoform 110K (human)" EXACT [UniProtKB:Q969H0]
synonym: "F-box/WD repeat-containing protein 7 isoform common (human)" EXACT [UniProtKB:Q969H0]
synonym: "F-box/WD repeat-containing protein 7 isoform FBW7alpha (human)" EXACT [UniProtKB:Q969H0]
synonym: "F-box/WD repeat-containing protein 7 isoform Archipelago alpha (human)" EXACT [UniProtKB:Q969H0]
xref: Reactome:R-HSA-1602296 "PR:Q969H0-1 located_in GO:0005654"
xref: UniProtKB:Q969H0-1
is_a: PR:Q969H0 ! F-box/WD repeat-containing protein 7 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q969H0-2
name: F-box/WD repeat-containing protein 7 isoform h2 (human)
def: "An F-box/WD repeat-containing protein 7 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q969H0-2." [PRO:DNx, UniProtKB:Q969H0]
comment: Category=organism-sequence.
synonym: "hFBXW7/iso:h2" EXACT PRO-short-label [PRO:DNx]
synonym: "F-box/WD repeat-containing protein 7 isoform 69K (human)" EXACT [UniProtKB:Q969H0]
synonym: "F-box/WD repeat-containing protein 7 isoform FBW7beta (human)" EXACT [UniProtKB:Q969H0]
synonym: "F-box/WD repeat-containing protein 7 isoform Archipelago beta (human)" EXACT [UniProtKB:Q969H0]
xref: UniProtKB:Q969H0-2
is_a: PR:Q969H0 ! F-box/WD repeat-containing protein 7 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens