[Term]
id: PR:Q01543-4
name: Friend leukemia integration 1 transcription factor isoform h4 (human)
def: "A Friend leukemia integration 1 transcription factor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q01543-4." [PRO:DNx, UniProtKB:Q01543]
comment: Category=organism-sequence.
synonym: "hFLI1/iso:h4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q01543-4
is_a: PR:Q01543 ! Friend leukemia integration 1 transcription factor (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q01543-2
name: Friend leukemia integration 1 transcription factor isoform h2 (human)
def: "A Friend leukemia integration 1 transcription factor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q01543-2." [PRO:DNx, UniProtKB:Q01543]
comment: Category=organism-sequence.
synonym: "hFLI1/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q01543-2
is_a: PR:Q01543 ! Friend leukemia integration 1 transcription factor (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q01543-3
name: Friend leukemia integration 1 transcription factor isoform h3 (human)
def: "A Friend leukemia integration 1 transcription factor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q01543-3." [PRO:DNx, UniProtKB:Q01543]
comment: Category=organism-sequence.
synonym: "hFLI1/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q01543-3
is_a: PR:Q01543 ! Friend leukemia integration 1 transcription factor (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q01543-1
name: Friend leukemia integration 1 transcription factor isoform 1 (human)
def: "A Friend leukemia integration 1 transcription factor isoform 1 that is encoded in the genome of human." [PRO:PD]
comment: Category=organism-sequence.
synonym: "hFLI1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q01543-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000028814 ! Friend leukemia integration 1 transcription factor isoform 1

[Term]
id: PR:Q01543
name: Friend leukemia integration 1 transcription factor (human)
def: "A Friend leukemia integration 1 transcription factor that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q01543]
comment: Category=organism-gene.
synonym: "FLI1" RELATED Gene-based [UniProtKB:Q01543]
synonym: "hFLI1" EXACT PRO-short-label [PRO:DNx]
synonym: "proto-oncogene Fli-1 (human)" EXACT [UniProtKB:Q01543]
synonym: "transcription factor ERGB (human)" EXACT [UniProtKB:Q01543]
xref: Reactome:R-HSA-9616216 "PR:Q01543 located_in GO:0005654"
xref: UniProtKB:Q01543
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000007553 ! Friend leukemia integration 1 transcription factor
relationship: has_gene_template HGNC:3749 ! FLI1 (human)

[Term]
id: PR:000028814
name: Friend leukemia integration 1 transcription factor isoform 1
def: "A Friend leukemia integration 1 transcription factor that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q01543-1 or a 1:1 ortholog thereof." [PMID:17884818, PRO:PD]
comment: Category=sequence.
synonym: "FLI1/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000007553 ! Friend leukemia integration 1 transcription factor

[Term]
id: PR:000028817
name: Friend leukemia integration 1 transcription factor isoform 1 acetylated 1 (human)
def: "A Friend leukemia integration 1 transcription factor isoform 1 acetylated 1 in human. Acetylation decreases protein stability, inhibits DNA binding and modulates Fli1 repressor function. UniProtKB:Q01543-1, Lys-380, MOD:00064." [PMID:17884818, PRO:PD]
comment: Category=organism-modification. Acetylase=("KAT2B"; PR:000012332).
synonym: "hFLI1/iso:1/Ac:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q01543-1, Lys-380, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000028816 ! Friend leukemia integration 1 transcription factor isoform 1 acetylated 1
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine

[Term]
id: PR:000028816
name: Friend leukemia integration 1 transcription factor isoform 1 acetylated 1
def: "A Friend leukemia integration 1 transcription factor isoform 1 that has been acetylated on a Lys residue located between the Ets binding site and the C-terminal activation domain. Example: UniProtKB:Q01543-1, Lys-380, MOD:00064." [PMID:17884818, PRO:PD]
comment: Category=modification.
synonym: "FLI1/iso:1/Ac:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000028814 ! Friend leukemia integration 1 transcription factor isoform 1
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine

[Term]
id: PR:000007553
name: Friend leukemia integration 1 transcription factor
def: "A protein that is a translation product of the human FLI1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "FLI1" EXACT PRO-short-label [PRO:DNx]
synonym: "Fli-1" RELATED Gene-based []
synonym: "proto-oncogene Fli-1" EXACT []
synonym: "transcription factor ERGB" EXACT []
synonym: "retroviral integration site protein Fli-1" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000045869
name: Friend leukemia integration 1 transcription factor phosphorylated 1 (human)
def: "A Friend leukemia integration 1 transcription factor (human) that has been phosphorylated on the residue at the position equivalent to Thr-312 of the amino acid sequence represented by UniProtKB:Q01543-1. Example: UniProtKB:Q01543-1, Thr-312, MOD:00047." [PMID:25707716, iPTMnet:Q01543]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:25707716). Status=unreviewed.
synonym: "hFLI1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q01543-1, Thr-312, MOD:00047" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:Q01543 ! Friend leukemia integration 1 transcription factor (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P26323
name: Friend leukemia integration 1 transcription factor (mouse)
def: "A Friend leukemia integration 1 transcription factor that is encoded in the genome of mouse." [OMA:P26323, PRO:DNx]
comment: Category=organism-gene.
synonym: "Fli1" RELATED Gene-based [UniProtKB:P26323]
synonym: "Fli-1" RELATED Gene-based [UniProtKB:P26323]
synonym: "mFLI1" EXACT PRO-short-label [PRO:DNx]
synonym: "retroviral integration site protein Fli-1 (mouse)" EXACT [UniProtKB:P26323]
xref: UniProtKB:P26323
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000007553 ! Friend leukemia integration 1 transcription factor
relationship: has_gene_template MGI:95554 ! Fli1 (mouse)