[Term] id: PR:G5ECR8 name: putative glucosylceramidase 3 (worm) def: "A lysosomal acid glucosylceramidase that is encoded in the genome of worm." [PRO:DNx] comment: Category=organism-gene. synonym: "gba-3" RELATED Gene-based [UniProtKB:G5ECR8] synonym: "F11E6.1" RELATED Gene-based [UniProtKB:G5ECR8] synonym: "GBA (worm)" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:G5ECR8 intersection_of: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans intersection_of: PR:000007867 ! lysosomal acid glucosylceramidase relationship: has_gene_template WormBase:WBGene00008706 ! gba-3 (worm) [Term] id: PR:000007867 name: lysosomal acid glucosylceramidase def: "A protein that is a translation product of the human GBA gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "GC" RELATED Gene-based [] synonym: "GBA" EXACT PRO-short-label [PRO:DNx] synonym: "GBA1" RELATED Gene-based [] synonym: "GLUC" RELATED Gene-based [] synonym: "SGTase" EXACT [] synonym: "alglucerase" EXACT [] synonym: "imiglucerase" EXACT [] synonym: "lysosomal acid GCase" EXACT [] synonym: "acid beta-glucosidase" EXACT [] synonym: "beta-glucocerebrosidase" EXACT [] synonym: "cholesteryl-beta-glucosidase" EXACT [] synonym: "lysosomal glycosylceramidase" EXACT [] synonym: "lysosomal galactosylceramidase" EXACT [] synonym: "cholesterol glucosyltransferase" EXACT [] synonym: "lysosomal cholesterol glycosyltransferase" EXACT [] synonym: "D-glucosyl-N-acylsphingosine glucohydrolase" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:G5ECR8-4 name: putative glucosylceramidase 3 isoform d (worm) def: "A putative glucosylceramidase 3 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:G5ECR8-4." [PRO:DNx, UniProtKB:G5ECR8] comment: Category=organism-sequence. synonym: "GBA/iso:d (worm)" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:G5ECR8-4 is_a: PR:G5ECR8 ! putative glucosylceramidase 3 (worm) relationship: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans [Term] id: PR:000019975 name: lysosomal acid glucosylceramidase, signal peptide removed form def: "A lysosomal acid glucosylceramidase that has had the signal peptide removed." [PRO:DNx] comment: Category=modification. synonym: "GBA/SigPep-" EXACT PRO-short-label [PRO:DNx] intersection_of: PR:000007867 ! lysosomal acid glucosylceramidase intersection_of: lacks_part SO:0000418 ! signal_peptide [Term] id: PR:G5ECR8-2 name: putative glucosylceramidase 3 isoform b (worm) def: "A putative glucosylceramidase 3 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:G5ECR8-2." [PRO:DNx, UniProtKB:G5ECR8] comment: Category=organism-sequence. synonym: "GBA/iso:b (worm)" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:G5ECR8-2 is_a: PR:G5ECR8 ! putative glucosylceramidase 3 (worm) relationship: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans [Term] id: PR:G5ECR8-1 name: putative glucosylceramidase 3 isoform a (worm) def: "A putative glucosylceramidase 3 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:G5ECR8-1." [PRO:DNx, UniProtKB:G5ECR8] comment: Category=organism-sequence. synonym: "GBA/iso:a (worm)" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:G5ECR8-1 is_a: PR:G5ECR8 ! putative glucosylceramidase 3 (worm) relationship: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans [Term] id: PR:Q8IMY3 name: lysosomal acid glucosylceramidase (fruit fly) def: "A lysosomal acid glucosylceramidase that is encoded in the genome of fruit fly." [PANTHER:PTHR11069:SF2, PRO:DNx] comment: Category=organism-gene. synonym: "fly-GBA" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q8IMY3 intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster intersection_of: PR:000007867 ! lysosomal acid glucosylceramidase relationship: has_gene_template FlyBase:FBgn0051414 ! CG31414 (fruit fly) [Term] id: PR:P04062 name: lysosomal acid glucosylceramidase (human) def: "A lysosomal acid glucosylceramidase that is encoded in the genome of human." [PRO:DNx, UniProtKB:P04062] comment: Category=organism-gene. synonym: "GC" RELATED Gene-based [UniProtKB:P04062] synonym: "GBA" RELATED Gene-based [UniProtKB:P04062] synonym: "GBA1" RELATED Gene-based [UniProtKB:P04062] synonym: "GLUC" RELATED Gene-based [UniProtKB:P04062] synonym: "hGBA" EXACT PRO-short-label [PRO:DNx] synonym: "SGTase (human)" EXACT [UniProtKB:P04062] synonym: "beta-GC (human)" EXACT [UniProtKB:P04062] synonym: "alglucerase (human)" EXACT [UniProtKB:P04062] synonym: "imiglucerase (human)" EXACT [UniProtKB:P04062] synonym: "lysosomal acid GCase (human)" EXACT [UniProtKB:P04062] synonym: "acid beta-glucosidase (human)" EXACT [UniProtKB:P04062] synonym: "beta-glucocerebrosidase (human)" EXACT [UniProtKB:P04062] synonym: "beta-glucosylceramidase 1 (human)" EXACT [UniProtKB:P04062] synonym: "glucosylceramidase beta 1 (human)" EXACT [UniProtKB:P04062] synonym: "cholesteryl-beta-glucosidase (human)" EXACT [UniProtKB:P04062] synonym: "lysosomal glycosylceramidase (human)" EXACT [UniProtKB:P04062] synonym: "lysosomal galactosylceramidase (human)" EXACT [UniProtKB:P04062] synonym: "cholesterol glucosyltransferase (human)" EXACT [UniProtKB:P04062] synonym: "lysosomal cholesterol glycosyltransferase (human)" EXACT [UniProtKB:P04062] synonym: "D-glucosyl-N-acylsphingosine glucohydrolase (human)" EXACT [UniProtKB:P04062] xref: UniProtKB:P04062 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000007867 ! lysosomal acid glucosylceramidase relationship: has_gene_template HGNC:4177 ! GBA (human) [Term] id: PR:P04062-4 name: lysosomal acid glucosylceramidase isoform h4 (human) def: "A lysosomal acid glucosylceramidase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04062-4." [PRO:DNx, UniProtKB:P04062] comment: Category=organism-sequence. synonym: "hGBA/iso:h4" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P04062-4 is_a: PR:P04062 ! lysosomal acid glucosylceramidase (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P04062-5 name: lysosomal acid glucosylceramidase isoform h5 (human) def: "A lysosomal acid glucosylceramidase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04062-5." [PRO:DNx, UniProtKB:P04062] comment: Category=organism-sequence. synonym: "hGBA/iso:h5" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P04062-5 is_a: PR:P04062 ! lysosomal acid glucosylceramidase (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P17439 name: lysosomal acid glucosylceramidase (mouse) def: "A lysosomal acid glucosylceramidase that is encoded in the genome of mouse." [OMA:P17439, PRO:DNx] comment: Category=organism-gene. synonym: "Gba" RELATED Gene-based [UniProtKB:P17439] synonym: "Gba1" RELATED Gene-based [UniProtKB:P17439] synonym: "mGBA" EXACT PRO-short-label [PRO:DNx] synonym: "SGTase (mouse)" EXACT [UniProtKB:P17439] synonym: "lysosomal acid GCase (mouse)" EXACT [UniProtKB:P17439] synonym: "acid beta-glucosidase (mouse)" EXACT [UniProtKB:P17439] synonym: "beta-glucocerebrosidase (mouse)" EXACT [UniProtKB:P17439] synonym: "cholesteryl-beta-glucosidase (mouse)" EXACT [UniProtKB:P17439] synonym: "lysosomal glycosylceramidase (mouse)" EXACT [UniProtKB:P17439] synonym: "lysosomal galactosylceramidase (mouse)" EXACT [UniProtKB:P17439] synonym: "cholesterol glucosyltransferase (mouse)" EXACT [UniProtKB:P17439] synonym: "lysosomal cholesterol glycosyltransferase (mouse)" EXACT [UniProtKB:P17439] synonym: "D-glucosyl-N-acylsphingosine glucohydrolase (mouse)" EXACT [UniProtKB:P17439] xref: UniProtKB:P17439 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000007867 ! lysosomal acid glucosylceramidase relationship: has_gene_template MGI:95665 ! Gba (mouse) [Term] id: PR:000047513 name: lysosomal acid glucosylceramidase, signal peptide removed form (human) def: "A lysosomal acid glucosylceramidase (human) that has had the signal peptide removed. UniProtKB:P04062, 40-536." [PRO:DNx, Reactome:R-HSA-1605775, Reactome:R-HSA-6813790] comment: Category=organism-modification. synonym: "hGBA/SigPep-" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000012177" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:P04062, 40-536" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-1605775 "PR:000047513 located_in GO:0005765" xref: Reactome:R-HSA-6813790 "PR:000047513 located_in GO:0005829" intersection_of: PR:P04062 ! lysosomal acid glucosylceramidase (human) intersection_of: lacks_part SO:0000418 ! signal_peptide relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P04062-1 name: lysosomal acid glucosylceramidase isoform Long (human) def: "A lysosomal acid glucosylceramidase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04062-1." [PRO:DNx, UniProtKB:P04062] comment: Category=organism-sequence. synonym: "hGBA/iso:Long" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P04062-1 is_a: PR:P04062 ! lysosomal acid glucosylceramidase (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P04062-2 name: lysosomal acid glucosylceramidase isoform Short (human) def: "A lysosomal acid glucosylceramidase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04062-2." [PRO:DNx, UniProtKB:P04062] comment: Category=organism-sequence. synonym: "hGBA/iso:Short" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P04062-2 is_a: PR:P04062 ! lysosomal acid glucosylceramidase (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P04062-3 name: lysosomal acid glucosylceramidase isoform h3 (human) def: "A lysosomal acid glucosylceramidase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04062-3." [PRO:DNx, UniProtKB:P04062] comment: Category=organism-sequence. synonym: "hGBA/iso:h3" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P04062-3 is_a: PR:P04062 ! lysosomal acid glucosylceramidase (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens