[Term] id: PR:P49841 name: glycogen synthase kinase-3 beta (human) def: "A glycogen synthase kinase-3 beta that is encoded in the genome of human." [PRO:DNx, UniProtKB:P49841] comment: Category=organism-gene. synonym: "GSK3B" RELATED Gene-based [UniProtKB:P49841] synonym: "hGSK3B" EXACT PRO-short-label [PRO:DNx] synonym: "GSK-3 beta (human)" EXACT [UniProtKB:P49841] synonym: "serine/threonine-protein kinase GSK3B (human)" EXACT [UniProtKB:P49841] xref: Reactome:R-HSA-2022823 "PR:P49841 located_in GO:0005654" xref: Reactome:R-HSA-2997551 "PR:P49841 located_in GO:0005829" xref: DTO:03100165 xref: UniProtKB:P49841 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000008288 ! glycogen synthase kinase-3 beta relationship: has_gene_template HGNC:4617 ! GSK3B (human) [Term] id: PR:000008288 name: glycogen synthase kinase-3 beta def: "A glycogen synthase kinase 3 that is a translation product of the human GSK3B gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "GSK3B" EXACT PRO-short-label [PRO:DNx] synonym: "GSK-3 beta" EXACT [] synonym: "serine/threonine-protein kinase GSK3B" EXACT [] xref: IUPHARobj:2030 is_a: PR:000050019 ! glycogen synthase kinase 3 [Term] id: PR:000047635 name: glycogen synthase kinase-3 beta phosphorylated 2 (human) def: "A glycogen synthase kinase-3 beta (human) that has been phosphorylated on the residue at the position equivalent to Ser-9 of the amino acid sequence represented by UniProtKB:P49841. UniProtKB:P49841, Ser-9, MOD:00046." [PRO:DNx, Reactome:R-HSA-3149577] comment: Category=organism-modification. synonym: "hGSK3B/Phos:2" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P49841, Ser-9, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-3149577 "PR:000047635 located_in GO:0005829" is_a: PR:P49841 ! glycogen synthase kinase-3 beta (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000039611 name: glycogen synthase kinase-3 beta isoform 1 def: "A glycogen synthase kinase-3 beta that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49841-1 or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=sequence. synonym: "GSK3B/iso:1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000008288 ! glycogen synthase kinase-3 beta [Term] id: PR:P18431-3 name: protein kinase shaggy isoform SGG39 (fruit fly) def: "A protein kinase shaggy (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P18431-3." [PRO:DNx, UniProtKB:P18431] comment: Category=organism-sequence. synonym: "fly-GSK3B/iso:SGG39" EXACT PRO-short-label [PRO:DNx] synonym: "protein kinase shaggy isoform A (fruit fly)" EXACT [UniProtKB:P18431] synonym: "protein kinase shaggy isoform J (fruit fly)" EXACT [UniProtKB:P18431] xref: UniProtKB:P18431-3 is_a: PR:P18431 ! protein kinase shaggy (fruit fly) relationship: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster [Term] id: PR:P18431-2 name: protein kinase shaggy isoform Zygotic (fruit fly) def: "A protein kinase shaggy (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P18431-2." [PRO:DNx, UniProtKB:P18431] comment: Category=organism-sequence. synonym: "fly-GSK3B/iso:Zygotic" EXACT PRO-short-label [PRO:DNx] synonym: "protein kinase shaggy isoform B (fruit fly)" EXACT [UniProtKB:P18431] synonym: "protein kinase shaggy isoform C (fruit fly)" EXACT [UniProtKB:P18431] xref: UniProtKB:P18431-2 is_a: PR:P18431 ! protein kinase shaggy (fruit fly) relationship: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster [Term] id: PR:P49841-2 name: glycogen synthase kinase-3 beta isoform h2 (human) def: "A glycogen synthase kinase-3 beta (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49841-2." [PRO:DNx, UniProtKB:P49841] comment: Category=organism-sequence. synonym: "hGSK3B/iso:h2" EXACT PRO-short-label [PRO:DNx] synonym: "glycogen synthase kinase-3 beta isoform GSK-3beta2 (human)" EXACT [UniProtKB:P49841] synonym: "glycogen synthase kinase-3 beta isoform neuron-specific (human)" EXACT [UniProtKB:P49841] xref: UniProtKB:P49841-2 is_a: PR:P49841 ! glycogen synthase kinase-3 beta (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P18266-1 name: glycogen synthase kinase-3 beta isoform 1 (rat) def: "A glycogen synthase kinase-3 beta isoform 1 that is encoded in the genome of rat." [PRO:DNx] comment: Category=organism-sequence. synonym: "rGSK3B/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P18266-1 intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus intersection_of: PR:000039611 ! glycogen synthase kinase-3 beta isoform 1 [Term] id: PR:P18431-4 name: protein kinase shaggy isoform G (fruit fly) def: "A protein kinase shaggy (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P18431-4." [PRO:DNx, UniProtKB:P18431] comment: Category=organism-sequence. synonym: "fly-GSK3B/iso:G" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P18431-4 is_a: PR:P18431 ! protein kinase shaggy (fruit fly) relationship: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster [Term] id: PR:P18431 name: protein kinase shaggy (fruit fly) def: "A glycogen synthase kinase-3 beta that is encoded in the genome of fruit fly." [OMA:P18431, PRO:DNx] comment: Category=organism-gene. synonym: "sgg" RELATED Gene-based [UniProtKB:P18431] synonym: "zw3" RELATED Gene-based [UniProtKB:P18431] synonym: "gsk3" RELATED Gene-based [UniProtKB:P18431] synonym: "CG2621" RELATED Gene-based [UniProtKB:P18431] synonym: "fly-GSK3B" EXACT PRO-short-label [PRO:DNx] synonym: "protein zeste-white 3 (fruit fly)" EXACT [UniProtKB:P18431] xref: UniProtKB:P18431 intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster intersection_of: PR:000008288 ! glycogen synthase kinase-3 beta relationship: has_gene_template FlyBase:FBgn0003371 ! sgg (fruit fly) [Term] id: PR:000049789 name: glycogen synthase kinase-3 beta unphosphorylated 1 (mouse) def: "A glycogen synthase kinase-3 beta (mouse) that lacks phosphorylation at the position equivalent to Ser-9 of the amino acid sequence represented by UniProtKB:Q9WV60. UniProtKB:Q9WV60, Ser-9, PR:000026291." [PMID:26582204, PRO:HJD] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:26582204). synonym: "mGSK3B/UnPhos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q9WV60, Ser-9, PR:000026291" EXACT PRO-proteoform-std [PRO:DNx] is_a: PR:Q9WV60 ! glycogen synthase kinase-3 beta (mouse) relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus [Term] id: PR:000045698 name: glycogen synthase kinase-3 beta phosphorylated 1 (rat) def: "A glycogen synthase kinase-3 beta (rat) that has been phosphorylated at Ser-9. UniProtKB:P18266, Ser-9, MOD:00046." [PMID:11094086, PMID:12421827, iPTMnet:P18266] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:11094086, PMID:12421827). Status=unreviewed. synonym: "rGSK3B/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P18266, Ser-9, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] is_a: PR:P18266 ! glycogen synthase kinase-3 beta (rat) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus [Term] id: PR:Q9WV60 name: glycogen synthase kinase-3 beta (mouse) def: "A glycogen synthase kinase-3 beta that is encoded in the genome of mouse." [OMA:Q9WV60, PRO:DNx] comment: Category=organism-gene. synonym: "Gsk3b" RELATED Gene-based [UniProtKB:Q9WV60] synonym: "mGSK3B" EXACT PRO-short-label [PRO:DNx] synonym: "GSK-3 beta (mouse)" EXACT [UniProtKB:Q9WV60] synonym: "serine/threonine-protein kinase GSK3B (mouse)" EXACT [UniProtKB:Q9WV60] xref: UniProtKB:Q9WV60 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000008288 ! glycogen synthase kinase-3 beta relationship: has_gene_template MGI:1861437 ! Gsk3b (mouse) [Term] id: PR:000046095 name: glycogen synthase kinase-3 beta phosphorylated 1 (mouse) def: "A glycogen synthase kinase-3 beta (mouse) that has been phosphorylated at Ser-9. UniProtKB:Q9WV60, Ser-9, MOD:00046." [PMID:16522636, PMID:26582204, PRO:HJD, iPTMnet:Q9WV60] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:16522636). Evidence=(ECO:0000006, based on PMID:26582204). synonym: "mGSK3B/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "inactive mGSK3B" RELATED [] synonym: "UniProtKB:Q9WV60, Ser-9, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] is_a: PR:Q9WV60 ! glycogen synthase kinase-3 beta (mouse) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus [Term] id: PR:000046173 name: serine/threonine-protein kinase RIM11/MSD1 phosphorylated 1 (yeast) def: "A serine/threonine-protein kinase RIM11/MSD1 (yeast) that has been phosphorylated at Tyr-199. UniProtKB:P38615, Tyr-199, MOD:00048." [PMID:10679022, iPTMnet:P38615] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:10679022). Status=unreviewed. synonym: "yGSK3B/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P38615, Tyr-199, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx] is_a: PR:P38615 ! serine/threonine-protein kinase RIM11/MSD1 (yeast) relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine relationship: only_in_taxon NCBITaxon:559292 ! Saccharomyces cerevisiae S288C [Term] id: PR:P18431-1 name: protein kinase shaggy isoform SGG46 (fruit fly) def: "A protein kinase shaggy (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P18431-1." [PRO:DNx, UniProtKB:P18431] comment: Category=organism-sequence. synonym: "fly-GSK3B/iso:SGG46" EXACT PRO-short-label [PRO:DNx] synonym: "protein kinase shaggy isoform D (fruit fly)" EXACT [UniProtKB:P18431] synonym: "protein kinase shaggy isoform Maternal (fruit fly)" EXACT [UniProtKB:P18431] xref: UniProtKB:P18431-1 is_a: PR:P18431 ! protein kinase shaggy (fruit fly) relationship: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster [Term] id: PR:Q9WV60-1 name: glycogen synthase kinase-3 beta isoform 1 (mouse) def: "A glycogen synthase kinase-3 beta isoform 1 that is encoded in the genome of mouse." [PRO:DNx] comment: Category=organism-sequence. synonym: "mGSK3B/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q9WV60-1 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000039611 ! glycogen synthase kinase-3 beta isoform 1 [Term] id: PR:P38615 name: serine/threonine-protein kinase RIM11/MSD1 (yeast) def: "A glycogen synthase kinase-3 beta that is encoded in the genome of yeast." [OMA:P38615, PRO:DNx] comment: Category=organism-gene. synonym: "GSK3" RELATED Gene-based [UniProtKB:P38615] synonym: "MDS1" RELATED Gene-based [UniProtKB:P38615] synonym: "RIM11" RELATED Gene-based [UniProtKB:P38615] synonym: "yGSK3B" EXACT PRO-short-label [PRO:DNx] synonym: "YMR139W" RELATED Gene-based [UniProtKB:P38615] synonym: "YM9375.08" RELATED Gene-based [UniProtKB:P38615] synonym: "regulator of IME2 protein 11 (yeast)" EXACT [UniProtKB:P38615] xref: UniProtKB:P38615 intersection_of: only_in_taxon NCBITaxon:559292 ! Saccharomyces cerevisiae S288C intersection_of: PR:000008288 ! glycogen synthase kinase-3 beta relationship: has_gene_template SGD:S000004747 ! RIM11 (yeast) [Term] id: PR:000045809 name: glycogen synthase kinase-3 beta phosphorylated 1 (human) def: "A glycogen synthase kinase-3 beta (human) that has been phosphorylated on the residue at the position equivalent to Tyr-216 of the amino acid sequence represented by UniProtKB:P49841-1. Example: UniProtKB:P49841-1, Tyr-216, MOD:00048." [PMID:15020233, PMID:17188038, iPTMnet:P49841] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:15020233, PMID:17188038). Status=unreviewed. synonym: "hGSK3B/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P49841-1, Tyr-216, MOD:00048" NARROW PRO-proteoform-std [PRO:DNx] is_a: PR:P49841 ! glycogen synthase kinase-3 beta (human) relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P49841-1 name: glycogen synthase kinase-3 beta isoform 1 (human) def: "A glycogen synthase kinase-3 beta isoform 1 that is encoded in the genome of human." [PRO:DNx] comment: Category=organism-sequence. Requested by=PubChem. synonym: "hGSK3B/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P49841-1 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000039611 ! glycogen synthase kinase-3 beta isoform 1 [Term] id: PR:P18266 name: glycogen synthase kinase-3 beta (rat) def: "A glycogen synthase kinase-3 beta that is encoded in the genome of rat." [OMA:P18266, PRO:DNx] comment: Category=organism-gene. synonym: "Gsk3b" RELATED Gene-based [UniProtKB:P18266] synonym: "rGSK3B" EXACT PRO-short-label [PRO:DNx] synonym: "FA (rat)" BROAD [UniProtKB:P18266] synonym: "factor A (rat)" BROAD [UniProtKB:P18266] synonym: "GSK-3 beta (rat)" EXACT [UniProtKB:P18266] synonym: "serine/threonine-protein kinase GSK3B (rat)" EXACT [UniProtKB:P18266] xref: UniProtKB:P18266 intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus intersection_of: PR:000008288 ! glycogen synthase kinase-3 beta relationship: has_gene_template RGD:70982 ! Gsk3b (rat)