[Term] id: PR:000037389 name: gap junction alpha-1 protein phosphorylated 1 (mouse) def: "A gap junction alpha-1 protein (mouse) that has been phosphorylated by pERK1/2 at positions Ser-279 and Ser-282 in UniProtKB:P23242. UniProtKB:P23242, Ser-279/Ser-282, MOD:00046." [PMID:23261543, PRO:HJD] comment: Category=organism-modification. synonym: "mGJA1/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P23242, Ser-279/Ser-282, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] is_a: PR:P23242 ! gap junction alpha-1 protein (mouse) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus [Term] id: PR:P17302 name: gap junction alpha-1 protein (human) def: "A gap junction alpha-1 protein that is encoded in the genome of human." [PRO:DNx, UniProtKB:P17302] comment: Category=organism-gene. synonym: "GJA1" RELATED Gene-based [UniProtKB:P17302] synonym: "GJAL" RELATED Gene-based [UniProtKB:P17302] synonym: "hGJA1" EXACT PRO-short-label [PRO:DNx] synonym: "Cx43 (human)" EXACT [UniProtKB:P17302] synonym: "connexin-43 (human)" EXACT [UniProtKB:P17302] synonym: "gap junction 43 kDa heart protein (human)" EXACT [UniProtKB:P17302] xref: UniProtKB:P17302 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000008373 ! gap junction alpha-1 protein relationship: has_gene_template HGNC:4274 ! GJA1 (human) [Term] id: PR:P08050 name: gap junction alpha-1 protein (rat) def: "A gap junction alpha-1 protein that is encoded in the genome of rat." [OMA:P08050, PRO:DNx] comment: Category=organism-gene. synonym: "Gja1" RELATED Gene-based [UniProtKB:P08050] synonym: "rGJA1" EXACT PRO-short-label [PRO:DNx] synonym: "Cxn-43" RELATED Gene-based [UniProtKB:P08050] synonym: "Cx43 (rat)" EXACT [UniProtKB:P08050] synonym: "connexin-43 (rat)" EXACT [UniProtKB:P08050] synonym: "gap junction 43 kDa heart protein (rat)" EXACT [UniProtKB:P08050] xref: UniProtKB:P08050 intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus intersection_of: PR:000008373 ! gap junction alpha-1 protein relationship: has_gene_template RGD:2690 ! Gja1 (rat) [Term] id: PR:000046134 name: gap junction alpha-1 protein phosphorylated 1 (rat) def: "A gap junction alpha-1 protein (rat) that has been phosphorylated at Tyr-265. UniProtKB:P08050, Tyr-265, MOD:00048." [PMID:11124251, iPTMnet:P08050] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:11124251). Status=unreviewed. synonym: "rGJA1/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P08050, Tyr-265, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx] is_a: PR:P08050 ! gap junction alpha-1 protein (rat) relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus [Term] id: PR:O57474-1 name: gap junction alpha-1 protein isoform 1 (zebrafish) def: "A gap junction alpha-1 protein (zebrafish) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O57474-1." [PRO:DNx, UniProtKB:O57474] comment: Category=organism-sequence. synonym: "z-GJA1/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:O57474-1 is_a: PR:O57474 ! gap junction alpha-1 protein (zebrafish) relationship: only_in_taxon NCBITaxon:7955 ! Danio rerio [Term] id: PR:P08050-1 name: gap junction alpha-1 protein isoform 1 (rat) def: "A gap junction alpha-1 protein isoform 1 that is encoded in the genome of rat." [PRO:DNx] comment: Category=organism-sequence. synonym: "rGJA1/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P08050-1 intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus intersection_of: PR:000038975 ! gap junction alpha-1 protein isoform 1 [Term] id: PR:P14154 name: gap junction alpha-1 protein (chicken) def: "A gap junction alpha-1 protein that is encoded in the genome of chicken." [OMA:P14154, PRO:DNx] comment: Category=organism-gene. synonym: "GJA1" RELATED Gene-based [UniProtKB:P14154] synonym: "chick-GJA1" EXACT PRO-short-label [PRO:DNx] synonym: "Cx43 (chicken)" EXACT [UniProtKB:P14154] synonym: "connexin-43 (chicken)" EXACT [UniProtKB:P14154] xref: UniProtKB:P14154 intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus intersection_of: PR:000008373 ! gap junction alpha-1 protein relationship: has_gene_template NCBIGene:395278 ! GJA1 (chicken) [Term] id: PR:P23242-1 name: gap junction alpha-1 protein isoform 1 (mouse) def: "A gap junction alpha-1 protein isoform 1 that is encoded in the genome of mouse." [PRO:DNx] comment: Category=organism-sequence. synonym: "mGJA1/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P23242-1 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000038975 ! gap junction alpha-1 protein isoform 1 [Term] id: PR:O57474-2 name: gap junction alpha-1 protein isoform 2 (zebrafish) def: "A gap junction alpha-1 protein (zebrafish) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O57474-2." [PRO:DNx, UniProtKB:O57474] comment: Category=organism-sequence. synonym: "z-GJA1/iso:2" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:O57474-2 is_a: PR:O57474 ! gap junction alpha-1 protein (zebrafish) relationship: only_in_taxon NCBITaxon:7955 ! Danio rerio [Term] id: PR:000037390 name: gap junction alpha-1 protein unphosphorylated 1 (mouse) def: "A gap junction alpha-1 protein (mouse) that lacks phosphorylated residues at positions Ser-279 and Ser-282 in UniProtKB:P23242. UniProtKB:P23242, Ser-279/Ser-282, PR:000026291." [PMID:23261543, PRO:HJD] comment: Category=organism-modification. synonym: "mGJA1/UnPhos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P23242, Ser-279/Ser-282, PR:000026291" EXACT PRO-proteoform-std [PRO:DNx] is_a: PR:P23242 ! gap junction alpha-1 protein (mouse) relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus [Term] id: PR:000008373 name: gap junction alpha-1 protein def: "A connexin protein that is a translation product of the human GJA1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "Cx43" EXACT [] synonym: "GJA1" EXACT PRO-short-label [PRO:DNx] synonym: "GJAL" RELATED Gene-based [] synonym: "Cxn-43" RELATED Gene-based [] synonym: "connexin-43" EXACT [] synonym: "gap junction 43 kDa heart protein" EXACT [] xref: IUPHARobj:728 is_a: PR:000044679 ! connexin protein [Term] id: PR:000047537 name: gap junction alpha-1 protein, initiator methionine removed form (human) def: "A gap junction alpha-1 protein (human) that has had the initiator methionine removed. UniProtKB:P17302, 2-382." [PRO:DNx, Reactome:R-HSA-158058, Reactome:R-HSA-190544, Reactome:R-HSA-190649, Reactome:R-HSA-190654, Reactome:R-HSA-196173] comment: Category=organism-modification. synonym: "PRO_0000057801" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "hGJA1/InitMet-" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P17302, 2-382" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-196173 "PR:000047537 located_in GO:0005765" xref: Reactome:R-HSA-158058 "PR:000047537 located_in GO:0005886" xref: Reactome:R-HSA-190544 "PR:000047537 located_in GO:0030660" xref: Reactome:R-HSA-190649 "PR:000047537 located_in GO:0000139" xref: Reactome:R-HSA-190654 "PR:000047537 located_in GO:0005789" intersection_of: lacks_part PR:000021937 ! initiator methionine intersection_of: PR:P17302 ! gap junction alpha-1 protein (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:O57474-3 name: gap junction alpha-1 protein isoform 3 (zebrafish) def: "A gap junction alpha-1 protein (zebrafish) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O57474-3." [PRO:DNx, UniProtKB:O57474] comment: Category=organism-sequence. synonym: "z-GJA1/iso:3" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:O57474-3 is_a: PR:O57474 ! gap junction alpha-1 protein (zebrafish) relationship: only_in_taxon NCBITaxon:7955 ! Danio rerio [Term] id: PR:O57474 name: gap junction alpha-1 protein (zebrafish) def: "A gap junction alpha-1 protein that is encoded in the genome of zebrafish." [OMA:O57474, PRO:DNx] comment: Category=organism-gene. synonym: "shf" RELATED Gene-based [UniProtKB:O57474] synonym: "sof" RELATED Gene-based [UniProtKB:O57474] synonym: "cx43" RELATED Gene-based [UniProtKB:O57474] synonym: "gja1" RELATED Gene-based [UniProtKB:O57474] synonym: "gja1b" RELATED Gene-based [UniProtKB:O57474] synonym: "z-GJA1" EXACT PRO-short-label [PRO:DNx] synonym: "Cx43 (zebrafish)" EXACT [UniProtKB:O57474] synonym: "connexin-43 (zebrafish)" EXACT [UniProtKB:O57474] synonym: "short fin protein (zebrafish)" EXACT [UniProtKB:O57474] xref: UniProtKB:O57474 intersection_of: only_in_taxon NCBITaxon:7955 ! Danio rerio intersection_of: PR:000008373 ! gap junction alpha-1 protein relationship: has_gene_template ZFIN:ZDB-GENE-991105-4 ! gja1b (zebrafish) [Term] id: PR:P23242 name: gap junction alpha-1 protein (mouse) def: "A gap junction alpha-1 protein that is encoded in the genome of mouse." [OMA:P23242, PRO:DNx] comment: Category=organism-gene. synonym: "Gja1" RELATED Gene-based [UniProtKB:P23242] synonym: "mGJA1" EXACT PRO-short-label [PRO:DNx] synonym: "Cxn-43" RELATED Gene-based [UniProtKB:P23242] synonym: "Cx43 (mouse)" EXACT [UniProtKB:P23242] synonym: "connexin-43 (mouse)" EXACT [UniProtKB:P23242] synonym: "gap junction 43 kDa heart protein (mouse)" EXACT [UniProtKB:P23242] xref: UniProtKB:P23242 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000008373 ! gap junction alpha-1 protein relationship: has_gene_template MGI:95713 ! Gja1 (mouse) [Term] id: PR:P17302-1 name: gap junction alpha-1 protein isoform 1 (human) def: "A gap junction alpha-1 protein isoform 1 that is encoded in the genome of human." [PRO:DNx] comment: Category=organism-sequence. synonym: "hGJA1/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P17302-1 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000038975 ! gap junction alpha-1 protein isoform 1 [Term] id: PR:000045690 name: gap junction alpha-1 protein phosphorylated 1 (human) def: "A gap junction alpha-1 protein (human) that has been phosphorylated at Ser-373. UniProtKB:P17302, Ser-373, MOD:00046." [PMID:24213533, iPTMnet:P17302] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:24213533). Status=unreviewed. synonym: "hGJA1/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P17302, Ser-373, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] is_a: PR:P17302 ! gap junction alpha-1 protein (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000047538 name: gap junction alpha-1 protein, initiator methionine removed phosphorylated 2 (human) def: "A gap junction alpha-1 protein (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphotyrosine at position 265 of the amino acid sequence represented by UniProtKB:P17302. UniProtKB:P17302, 2-382, Tyr-265, MOD:00048." [PRO:DNx, Reactome:R-HSA-191657] comment: Category=organism-modification. synonym: "hGJA1/InitMet-/Phos:2" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000057801, Tyr-265, MOD:00048" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:P17302, 2-382, Tyr-265, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-191657 "PR:000047538 located_in GO:0005886" is_a: PR:P17302 ! gap junction alpha-1 protein (human) relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: lacks_part PR:000021937 ! initiator methionine [Term] id: PR:000038975 name: gap junction alpha-1 protein isoform 1 def: "A gap junction alpha-1 protein that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P17302-1 or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=sequence. synonym: "GJA1/iso:1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000008373 ! gap junction alpha-1 protein