[Term]
id: PR:V6CLA2
name: E3 ubiquitin-protein ligase hecd-1 (worm)
def: "An E3 ubiquitin-protein ligase HECTD1 that is encoded in the genome of worm." [OMA:V6CLA2, PRO:DNx]
comment: Category=organism-gene.
synonym: "hecd-1" RELATED Gene-based [UniProtKB:V6CLA2]
synonym: "C34D4.14" RELATED Gene-based [UniProtKB:V6CLA2]
synonym: "HECTD1 (worm)" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:V6CLA2
intersection_of: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans
intersection_of: PR:000008502 ! E3 ubiquitin-protein ligase HECTD1
relationship: has_gene_template WormBase:WBGene00016405 ! hecd-1 (worm)

[Term]
id: PR:000008502
name: E3 ubiquitin-protein ligase HECTD1
def: "A protein that is a translation product of the human HECTD1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "EULIR" EXACT []
synonym: "HECTD1" EXACT PRO-short-label [PRO:DNx]
synonym: "KIAA1131" RELATED Gene-based []
synonym: "E3 ligase for inhibin receptor" EXACT []
synonym: "HECT domain-containing protein 1" EXACT []
synonym: "HECT-type E3 ubiquitin transferase HECTD1" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:Q69ZR2
name: E3 ubiquitin-protein ligase HECTD1 (mouse)
def: "An E3 ubiquitin-protein ligase HECTD1 that is encoded in the genome of mouse." [OMA:Q69ZR2, PRO:DNx]
comment: Category=organism-gene.
synonym: "Opm" RELATED Gene-based [UniProtKB:Q69ZR2]
synonym: "Hectd1" RELATED Gene-based [UniProtKB:Q69ZR2]
synonym: "mHECTD1" EXACT PRO-short-label [PRO:DNx]
synonym: "Kiaa1131" RELATED Gene-based [UniProtKB:Q69ZR2]
synonym: "protein open mind (mouse)" EXACT [UniProtKB:Q69ZR2]
synonym: "HECT domain-containing protein 1 (mouse)" EXACT [UniProtKB:Q69ZR2]
synonym: "HECT-type E3 ubiquitin transferase HECTD1 (mouse)" EXACT [UniProtKB:Q69ZR2]
xref: UniProtKB:Q69ZR2
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000008502 ! E3 ubiquitin-protein ligase HECTD1
relationship: has_gene_template MGI:2384768 ! Hectd1 (mouse)

[Term]
id: PR:000044487
name: E3 ubiquitin-protein ligase HECTD1 ubiquitinated 1 (mouse)
def: "An E3 ubiquitin-protein ligase HECTD1 (mouse) that has been cross-linked to K63-linked polyubiquitin on one or more Lys residues by autocatalysis." [PMID:22431752, PRO:KRC]
comment: Category=organism-modification. UbLigase=("HECTD1"; PR:Q69ZR2). Evidence=(ECO:0000006, based on PMID:22431752). Note: PMID:22431752, Fig 2D shows the conjugation of K63-linked Ub chains onto Hectd1 is dependent on its ligase activity.
synonym: "mHECTD1 K63-Ub" RELATED []
synonym: "mHECTD1/Ubiq:1" EXACT PRO-short-label [PRO:DNx]
synonym: "HECT domain-containing protein 1 ubiquitinated 1(mouse)" EXACT [UniProtKB:Q69ZR2]
is_a: PR:Q69ZR2 ! E3 ubiquitin-protein ligase HECTD1 (mouse)
relationship: has_part MOD:01148 ! ubiquitinylated lysine
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q9ULT8
name: E3 ubiquitin-protein ligase HECTD1 (human)
def: "An E3 ubiquitin-protein ligase HECTD1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9ULT8]
comment: Category=organism-gene.
synonym: "HECTD1" RELATED Gene-based [UniProtKB:Q9ULT8]
synonym: "hHECTD1" EXACT PRO-short-label [PRO:DNx]
synonym: "KIAA1131" RELATED Gene-based [UniProtKB:Q9ULT8]
synonym: "EULIR (human)" EXACT [UniProtKB:Q9ULT8]
synonym: "E3 ligase for inhibin receptor (human)" EXACT [UniProtKB:Q9ULT8]
synonym: "HECT domain-containing protein 1 (human)" EXACT [UniProtKB:Q9ULT8]
xref: Reactome:R-HSA-5688966 "PR:Q9ULT8 located_in GO:0005829"
xref: UniProtKB:Q9ULT8
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000008502 ! E3 ubiquitin-protein ligase HECTD1
relationship: has_gene_template HGNC:20157 ! HECTD1 (human)

[Term]
id: PR:Q9VL06
name: E3 ubiquitin-protein ligase Ufd4 (fruit fly)
def: "An E3 ubiquitin-protein ligase HECTD1 that is encoded in the genome of fruit fly." [OMA:Q9VL06, PANTHER:PTHR11254:SF75, PRO:DNx]
comment: Category=organism-gene.
synonym: "Ufd4" RELATED Gene-based [UniProtKB:Q9VL06]
synonym: "CG5604" RELATED Gene-based [UniProtKB:Q9VL06]
synonym: "fly-HECTD1" EXACT PRO-short-label [PRO:DNx]
synonym: "ubiquitin fusion-degradation 4-like (fruit fly)" EXACT [UniProtKB:Q9VL06]
xref: UniProtKB:Q9VL06
intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster
intersection_of: PR:000008502 ! E3 ubiquitin-protein ligase HECTD1
relationship: has_gene_template FlyBase:FBgn0032208 ! Ufd4 (fruit fly)