[Term]
id: PR:P23527
name: histone H2B type 1-O (human)
def: "A histone H2B type 1-O that is encoded in the genome of human." [PRO:DNx, UniProtKB:P23527]
comment: Category=organism-gene.
synonym: "H2BFH" RELATED Gene-based [UniProtKB:P23527]
synonym: "H2BFN" RELATED Gene-based [UniProtKB:P23527]
synonym: "H2BC17" RELATED Gene-based [UniProtKB:P23527]
synonym: "hH2BC17" EXACT PRO-short-label [PRO:DNx]
synonym: "HIST1H2BO" RELATED Gene-based [UniProtKB:P23527]
synonym: "H2B/n (human)" EXACT [UniProtKB:P23527]
synonym: "histone H2B.2 (human)" EXACT [UniProtKB:P23527]
synonym: "histone H2B.n (human)" EXACT [UniProtKB:P23527]
synonym: "H2B-clustered histone 17 (human)" EXACT [UniProtKB:P23527]
xref: UniProtKB:P23527
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000008594 ! histone H2B type 1-O
relationship: has_gene_template HGNC:4758 ! H2BC17 (human)

[Term]
id: PR:000047822
name: histone H2B type 1-O, initiator methionine removed N6-acetyllysine form (human)
def: "A histone H2B type 1-O (human) that has had the initiator methionine removed and that includes at least one N6-acetyllysine. UniProtKB:P23527, 2-126, MOD:00064." [PRO:DNx, Reactome:R-HSA-4549268]
comment: Category=organism-modification.
synonym: "PRO_0000071834, MOD:00064" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hHIST1H2BO/InitMet-/N6AcLys+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P23527, 2-126, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-4549268 "PR:000047822 located_in GO:0005654"
intersection_of: has_part MOD:00064 ! N6-acetyl-L-lysine
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:P23527 ! histone H2B type 1-O (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000026655
name: histone H2B type 1-O, initiator methionine removed form
def: "A histone H2B type 1-O that has had the initiator methionine removed." [PRO:DNx]
comment: Category=modification.
synonym: "HIST1H2BO/InitMet-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000008594 ! histone H2B type 1-O
intersection_of: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000047817
name: histone H2B type 1-O, initiator methionine removed form (human)
def: "A histone H2B type 1-O (human) that has had the initiator methionine removed. UniProtKB:P23527, 2-126." [PRO:DNx, Reactome:R-HSA-181910, Reactome:R-HSA-977557]
comment: Category=organism-modification.
synonym: "PRO_0000071834" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hHIST1H2BO/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P23527, 2-126" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-181910 "PR:000047817 located_in GO:0005654"
xref: Reactome:R-HSA-977557 "PR:000047817 located_in GO:0005576"
xref: TDR:1449
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:P23527 ! histone H2B type 1-O (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000045130
name: histone H2B type 1-O, initiator methionine removed monomethylated 1 (human)
def: "A histone H2B type 1-O (human) that has had the initiator methionine removed and that has been monomethylated at the position equivalent to Lys-6 of the amino acid sequence represented by UniProtKB:P23527. UniProtKB:P23527, 2-126, Lys-6, MOD:00085." [HIstome_var_Hs:Histone_H2B_type_1-O, PMID:17512414, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H2B_type_1-O:H2BK5me1" BROAD [HIstome_ptm_Hs:H2BK5me1]
synonym: "hHIST1H2BO/InitMet-/Me1:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000071834, Lys-6, MOD:00085" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P23527, 2-126, Lys-6, MOD:00085" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P23527 ! histone H2B type 1-O (human)
relationship: has_part MOD:00085 ! N6-methyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045124
name: histone H2B type 1-O, initiator methionine removed phosphorylated 1 (human)
def: "A histone H2B type 1-O (human) that has had the initiator methionine removed and that has been phosphorylated on the residue at the position equivalent to Ser-15 of the amino acid sequence represented by UniProtKB:P23527. UniProtKB:P23527, 2-126, Ser-15, MOD:00046." [HIstome_var_Hs:Histone_H2B_type_1-O, PMID:12757711, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H2B_type_1-O:H2BS14ph" BROAD [HIstome_ptm_Hs:H2BS14ph]
synonym: "hHIST1H2BO/InitMet-/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000071834, Ser-15, MOD:00046" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P23527, 2-126, Ser-15, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: TDR:13247
is_a: PR:P23527 ! histone H2B type 1-O (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045125
name: histone H2B type 1-O, initiator methionine removed acetylated 2 (human)
def: "A histone H2B type 1-O (human) that has had the initiator methionine removed and that has been acetylated at the position equivalent to Lys-21 of the amino acid sequence represented by UniProtKB:P23527. UniProtKB:P23527, 2-126, Lys-21, MOD:00064." [HIstome_var_Hs:Histone_H2B_type_1-O, PMID:16283522, PMID:18552846, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H2B_type_1-O:H2BK20ac" BROAD [HIstome_ptm_Hs:H2BK20ac]
synonym: "hHIST1H2BO/InitMet-/Ac:2" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000071834, Lys-21, MOD:00064" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P23527, 2-126, Lys-21, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-4568713 "PR:000045125 located_in GO:0005654"
xref: TDR:12955
is_a: PR:P23527 ! histone H2B type 1-O (human)
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045126
name: histone H2B type 1-O, initiator methionine removed ADP-ribosylated 1 (human)
def: "A histone H2B type 1-O (human) that has had the initiator methionine removed and that has been ADP-ribosylated at the position equivalent to Lys-31 of the amino acid sequence represented by UniProtKB:P23527. UniProtKB:P23527, 2-126, Lys-31, MOD:01399." [HIstome_var_Hs:Histone_H2B_type_1-O, PMID:20525793, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H2B_type_1-O:H2BK30ar" BROAD [HIstome_ptm_Hs:H2BK30ar]
synonym: "hHIST1H2BO/InitMet-/ADPrib:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000071834, Lys-31, MOD:01399" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P23527, 2-126, Lys-31, MOD:01399" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P23527 ! histone H2B type 1-O (human)
relationship: has_part MOD:01399 ! N6-(ADP-ribosyl)-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045127
name: histone H2B type 1-O, initiator methionine removed ubiquitinated 1 (human)
def: "A histone H2B type 1-O (human) that has had the initiator methionine removed and that has been ubiquitinated on the lysine at the position equivalent to Lys-121 of the amino acid sequence represented by UniProtKB:P23527. UniProtKB:P23527, 2-126, Lys-121, MOD:01148." [HIstome_var_Hs:Histone_H2B_type_1-O, PMID:16307923, PMID:16713563, PMID:18400894, PMID:18832071, PMID:18923072, PMID:19575011, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification. Note: A correction of the sequence numbering of the source data (Reactome:R-HSA-6782549) rendered PR:000047823 identical to this entry.
synonym: "H2B_type_1-O:H2BK120ub" BROAD [HIstome_ptm_Hs:H2BK120ub]
synonym: "hHIST1H2BO/InitMet-/Ubiq:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000071834, Lys-121, MOD:01148" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P23527, 2-126, Lys-121, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-3364033 "PR:000045127 located_in GO:0005654"
is_a: PR:P23527 ! histone H2B type 1-O (human)
relationship: has_part MOD:01148 ! ubiquitinylated lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045133
name: histone H2B type 1-O, initiator methionine removed acetylated 7 (human)
def: "A histone H2B type 1-O (human) that has had the initiator methionine removed and that has been acetylated at the position equivalent to Lys-16 of the amino acid sequence represented by UniProtKB:P23527. UniProtKB:P23527, 2-126, Lys-16, MOD:00064." [HIstome_var_Hs:Histone_H2B_type_1-O, PMID:19883641, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H2B_type_1-O:H2BK15ac" BROAD [HIstome_ptm_Hs:H2BK15ac]
synonym: "hHIST1H2BO/InitMet-/Ac:7" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000071834, Lys-16, MOD:00064" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P23527, 2-126, Lys-16, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-4568681 "PR:000045133 located_in GO:0005654"
is_a: PR:P23527 ! histone H2B type 1-O (human)
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045132
name: histone H2B type 1-O, initiator methionine removed acetylated 6 (human)
def: "A histone H2B type 1-O (human) that has had the initiator methionine removed and that has been acetylated at the position equivalent to Lys-121 of the amino acid sequence represented by UniProtKB:P23527. UniProtKB:P23527, 2-126, Lys-121, MOD:00064." [HIstome_var_Hs:Histone_H2B_type_1-O, PMID:18552846, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H2B_type_1-O:H2BK120ac" BROAD [HIstome_ptm_Hs:H2BK120ac]
synonym: "hHIST1H2BO/InitMet-/Ac:6" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000071834, Lys-121, MOD:00064" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P23527, 2-126, Lys-121, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P23527 ! histone H2B type 1-O (human)
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045131
name: histone H2B type 1-O, initiator methionine removed acetylated 5 (human)
def: "A histone H2B type 1-O (human) that has had the initiator methionine removed and that has been acetylated at the position equivalent to Lys-47 of the amino acid sequence represented by UniProtKB:P23527. UniProtKB:P23527, 2-126, Lys-47, MOD:00064." [HIstome_var_Hs:Histone_H2B_type_1-O, PMID:20693536, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H2B_type_1-O:H2BK46ac" BROAD [HIstome_ptm_Hs:H2BK46ac]
synonym: "hHIST1H2BO/InitMet-/Ac:5" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000071834, Lys-47, MOD:00064" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P23527, 2-126, Lys-47, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P23527 ! histone H2B type 1-O (human)
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045123
name: histone H2B type 1-O, initiator methionine removed acetylated 1 (human)
def: "A histone H2B type 1-O (human) that has had the initiator methionine removed and that has been acetylated at the position equivalent to Lys-13 of the amino acid sequence represented by UniProtKB:P23527. UniProtKB:P23527, 2-126, Lys-13, MOD:00064." [HIstome_var_Hs:Histone_H2B_type_1-O, PMID:16283522, PMID:18552846, PMID:20693536, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H2B_type_1-O:H2BK12ac" BROAD [HIstome_ptm_Hs:H2BK12ac]
synonym: "hHIST1H2BO/InitMet-/Ac:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000071834, Lys-13, MOD:00064" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P23527, 2-126, Lys-13, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-4568712 "PR:000045123 located_in GO:0005654"
is_a: PR:P23527 ! histone H2B type 1-O (human)
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045128
name: histone H2B type 1-O, initiator methionine removed acetylated 3 (human)
def: "A histone H2B type 1-O (human) that has had the initiator methionine removed and that has been acetylated at the position equivalent to Lys-17 of the amino acid sequence represented by UniProtKB:P23527. UniProtKB:P23527, 2-126, Lys-17, MOD:00064." [HIstome_var_Hs:Histone_H2B_type_1-O, PMID:20693536, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H2B_type_1-O:H2BK16ac" BROAD [HIstome_ptm_Hs:H2BK16ac]
synonym: "hHIST1H2BO/InitMet-/Ac:3" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000071834, Lys-17, MOD:00064" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P23527, 2-126, Lys-17, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P23527 ! histone H2B type 1-O (human)
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045129
name: histone H2B type 1-O, initiator methionine removed acetylated 4 (human)
def: "A histone H2B type 1-O (human) that has had the initiator methionine removed and that has been acetylated at the position equivalent to Lys-6 of the amino acid sequence represented by UniProtKB:P23527. UniProtKB:P23527, 2-126, Lys-6, MOD:00064." [HIstome_var_Hs:Histone_H2B_type_1-O, PMID:18552846, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H2B_type_1-O:H2BK5ac" BROAD [HIstome_ptm_Hs:H2BK5ac]
synonym: "hHIST1H2BO/InitMet-/Ac:4" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000071834, Lys-6, MOD:00064" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P23527, 2-126, Lys-6, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-4568708 "PR:000045129 located_in GO:0005654"
xref: TDR:4275
is_a: PR:P23527 ! histone H2B type 1-O (human)
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000008594
name: histone H2B type 1-O
def: "A histone H2B that is a translation product of the human H2BC17 gene or a 1:1 ortholog thereof." [PRO:DAN]
comment: Category=gene.
synonym: "H2B/n" EXACT []
synonym: "H2BFH" RELATED Gene-based []
synonym: "H2BFN" RELATED Gene-based []
synonym: "H2BC17" EXACT PRO-short-label [PRO:DNx]
synonym: "HIST1H2BO" RELATED Gene-based []
synonym: "histone H2B.2" EXACT []
synonym: "histone H2B.n" EXACT []
is_a: PR:000036509 ! histone H2B