[Term] id: PR:000047837 name: histone H2A type 2-C, initiator methionine removed omega-methylated 3 (human) def: "A histone H2A type 2-C (human) that has had the initiator methionine removed and has been post-translationally modified to include omega-methyl-L-arginine at position 4 of the amino acid sequence represented by UniProtKB:Q16777. UniProtKB:Q16777, 2-129, Arg-4, MOD:00078." [PRO:DNx, Reactome:R-HSA-5244625] comment: Category=organism-modification. synonym: "hHIST2H2AC/InitMet-/Me1o:3" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000055238, Arg-4, MOD:00078" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:Q16777, 2-129, Arg-4, MOD:00078" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-5244625 "PR:000047837 located_in GO:0005654" is_a: PR:Q16777 ! histone H2A type 2-C (human) relationship: has_part MOD:00078 ! omega-N-methyl-L-arginine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: lacks_part PR:000021937 ! initiator methionine [Term] id: PR:000047839 name: histone H2A type 2-C, initiator methionine removed asymmetrically-dimethylated 3 (human) def: "A histone H2A type 2-C (human) that has had the initiator methionine removed and has been post-translationally modified to include asymmetric dimethyl-L-arginine at position 30 of the amino acid sequence represented by UniProtKB:Q16777. UniProtKB:Q16777, 2-129, Arg-30, MOD:00077." [PRO:DNx, Reactome:R-HSA-5244562] comment: Category=organism-modification. synonym: "hHIST2H2AC/InitMet-/Me2a:3" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000055238, Arg-30, MOD:00077" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:Q16777, 2-129, Arg-30, MOD:00077" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-5244562 "PR:000047839 located_in GO:0005654" is_a: PR:Q16777 ! histone H2A type 2-C (human) relationship: has_part MOD:00077 ! asymmetric dimethyl-L-arginine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: lacks_part PR:000021937 ! initiator methionine [Term] id: PR:Q16777 name: histone H2A type 2-C (human) def: "A histone H2A type 2-C that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q16777] comment: Category=organism-gene. synonym: "H2AFQ" RELATED Gene-based [UniProtKB:Q16777] synonym: "H2AC20" RELATED Gene-based [UniProtKB:Q16777] synonym: "hH2AC20" EXACT PRO-short-label [PRO:DNx] synonym: "HIST2H2AC" RELATED Gene-based [UniProtKB:Q16777] synonym: "histone H2A/q (human)" EXACT [UniProtKB:Q16777] synonym: "histone H2A-GL101 (human)" EXACT [UniProtKB:Q16777] synonym: "H2A-clustered histone 20 (human)" EXACT [UniProtKB:Q16777] xref: UniProtKB:Q16777 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000008597 ! histone H2A type 2-C relationship: has_gene_template HGNC:4738 ! H2AC20 (human) [Term] id: PR:000047836 name: histone H2A type 2-C, initiator methionine removed omega-methylated 2 (human) def: "A histone H2A type 2-C (human) that has had the initiator methionine removed and has been post-translationally modified to include omega-methyl-L-arginine at position 30 of the amino acid sequence represented by UniProtKB:Q16777. UniProtKB:Q16777, 2-129, Arg-30, MOD:00078." [PRO:DNx, Reactome:R-HSA-5244542] comment: Category=organism-modification. synonym: "hHIST2H2AC/InitMet-/Me1o:2" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000055238, Arg-30, MOD:00078" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:Q16777, 2-129, Arg-30, MOD:00078" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-5244542 "PR:000047836 located_in GO:0005654" is_a: PR:Q16777 ! histone H2A type 2-C (human) relationship: has_part MOD:00078 ! omega-N-methyl-L-arginine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: lacks_part PR:000021937 ! initiator methionine [Term] id: PR:000045003 name: histone H2A type 2-C, initiator methionine removed biotinylated 2 (human) def: "A histone H2A type 2-C (human) that has had the initiator methionine removed and that has been biotinylated at the position equivalent to Lys-10 of the amino acid sequence represented by UniProtKB:Q16777. UniProtKB:Q16777, 2-129, Lys-10, MOD:00126." [HIstome_var_Hs:Histone_H2A_type_2-C, PMID:16772434, PRO:DAN, PRO:JPB, PRO:JR] comment: Category=organism-modification. synonym: "H2A_type_2-C:H2AK9bio" BROAD [HIstome_ptm_Hs:H2AK9bio] synonym: "hHIST2H2AC/InitMet-/Btn:2" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000055238, Lys-10, MOD:00126" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:Q16777, 2-129, Lys-10, MOD:00126" EXACT PRO-proteoform-std [PRO:DNx] is_a: PR:Q16777 ! histone H2A type 2-C (human) relationship: has_part MOD:00126 ! N6-biotinyl-L-lysine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: lacks_part PR:000021937 ! initiator methionine [Term] id: PR:000045002 name: histone H2A type 2-C, initiator methionine removed acetylated 2 (human) def: "A histone H2A type 2-C (human) that has had the initiator methionine removed and that has been acetylated at the position equivalent to Lys-10 of the amino acid sequence represented by UniProtKB:Q16777. UniProtKB:Q16777, 2-129, Lys-10, MOD:00064." [HIstome_var_Hs:Histone_H2A_type_2-C, PMID:12937907, PMID:18552846, PRO:DAN, PRO:JPB, PRO:JR] comment: Category=organism-modification. synonym: "H2A_type_2-C:H2AK9ac" BROAD [HIstome_ptm_Hs:H2AK9ac] synonym: "hHIST2H2AC/InitMet-/Ac:2" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000055238, Lys-10, MOD:00064" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:Q16777, 2-129, Lys-10, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx] is_a: PR:Q16777 ! histone H2A type 2-C (human) relationship: has_part MOD:00064 ! N6-acetyl-L-lysine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: lacks_part PR:000021937 ! initiator methionine [Term] id: PR:000045001 name: histone H2A type 2-C, initiator methionine removed biotinylated 1 (human) def: "A histone H2A type 2-C (human) that has had the initiator methionine removed and that has been biotinylated at the position equivalent to Lys-14 of the amino acid sequence represented by UniProtKB:Q16777. UniProtKB:Q16777, 2-129, Lys-14, MOD:00126." [HIstome_var_Hs:Histone_H2A_type_2-C, PMID:16772434, PRO:DAN, PRO:JPB, PRO:JR] comment: Category=organism-modification. synonym: "H2A_type_2-C:H2AK13bio" BROAD [HIstome_ptm_Hs:H2AK13bio] synonym: "hHIST2H2AC/InitMet-/Btn:1" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000055238, Lys-14, MOD:00126" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:Q16777, 2-129, Lys-14, MOD:00126" EXACT PRO-proteoform-std [PRO:DNx] is_a: PR:Q16777 ! histone H2A type 2-C (human) relationship: has_part MOD:00126 ! N6-biotinyl-L-lysine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: lacks_part PR:000021937 ! initiator methionine [Term] id: PR:000045000 name: histone H2A type 2-C, initiator methionine removed phosphorylated 1 (human) def: "A histone H2A type 2-C (human) that has had the initiator methionine removed and that has been phosphorylated on the residue at the position equivalent to Ser-2 of the amino acid sequence represented by UniProtKB:Q16777. UniProtKB:Q16777, 2-129, Ser-2, MOD:00046." [HIstome_var_Hs:Histone_H2A_type_2-C, PMID:15010469, PRO:DAN, PRO:JPB, PRO:JR] comment: Category=organism-modification. synonym: "H2A_type_2-C:H2AS1ph" BROAD [HIstome_ptm_Hs:H2AS1ph] synonym: "hHIST2H2AC/InitMet-/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000055238, Ser-2, MOD:00046" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:Q16777, 2-129, Ser-2, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] is_a: PR:Q16777 ! histone H2A type 2-C (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: lacks_part PR:000021937 ! initiator methionine [Term] id: PR:000045004 name: histone H2A type 2-C, initiator methionine removed dimethylated 1 (human) def: "A histone H2A type 2-C (human) that has had the initiator methionine removed and that has been dimethylated at the position equivalent to Arg-4 of the amino acid sequence represented by UniProtKB:Q16777. UniProtKB:Q16777, 2-129, Arg-4, MOD:00783." [HIstome_var_Hs:Histone_H2A_type_2-C, PMID:18079182, PRO:DAN, PRO:JPB, PRO:JR] comment: Category=organism-modification. synonym: "H2A_type_2-C:H2AR3me2" BROAD [HIstome_ptm_Hs:H2AR3me2] synonym: "hHIST2H2AC/InitMet-/Me2:1" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000055238, Arg-4, MOD:00783" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:Q16777, 2-129, Arg-4, MOD:00783" EXACT PRO-proteoform-std [PRO:DNx] is_a: PR:Q16777 ! histone H2A type 2-C (human) relationship: has_part MOD:00783 ! dimethylated L-arginine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: lacks_part PR:000021937 ! initiator methionine [Term] id: PR:Q16777-1 name: histone H2A type 2-C isoform 1 (human) def: "A histone H2A type 2-C isoform 1 that is encoded in the genome of human." [PRO:DNx] comment: Category=organism-sequence. synonym: "hHIST2H2AC/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q16777-1 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000040741 ! histone H2A type 2-C isoform 1 [Term] id: PR:000047838 name: histone H2A type 2-C, initiator methionine removed asymmetrically-dimethylated 2 (human) def: "A histone H2A type 2-C (human) that has had the initiator methionine removed and has been post-translationally modified to include asymmetric dimethyl-L-arginine at position 12 of the amino acid sequence represented by UniProtKB:Q16777. UniProtKB:Q16777, 2-129, Arg-12, MOD:00077." [PRO:DNx, Reactome:R-HSA-5229306] comment: Category=organism-modification. synonym: "hHIST2H2AC/InitMet-/Me2a:2" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000055238, Arg-12, MOD:00077" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:Q16777, 2-129, Arg-12, MOD:00077" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-5229306 "PR:000047838 located_in GO:0005654" is_a: PR:Q16777 ! histone H2A type 2-C (human) relationship: has_part MOD:00077 ! asymmetric dimethyl-L-arginine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: lacks_part PR:000021937 ! initiator methionine [Term] id: PR:000047833 name: histone H2A type 2-C, initiator methionine removed form (human) def: "A histone H2A type 2-C (human) that has had the initiator methionine removed. UniProtKB:Q16777, 2-129." [PRO:DNx, Reactome:R-HSA-181892, Reactome:R-HSA-977563] comment: Category=organism-modification. synonym: "PRO_0000055238" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "hHIST2H2AC/InitMet-" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q16777, 2-129" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-181892 "PR:000047833 located_in GO:0005654" xref: Reactome:R-HSA-977563 "PR:000047833 located_in GO:0005576" intersection_of: lacks_part PR:000021937 ! initiator methionine intersection_of: PR:Q16777 ! histone H2A type 2-C (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000047841 name: histone H2A type 2-C, initiator methionine removed asymmetrically-dimethylated 5 (human) def: "A histone H2A type 2-C (human) that has had the initiator methionine removed and has been post-translationally modified to include asymmetric dimethyl-L-arginine at position 4 of the amino acid sequence represented by UniProtKB:Q16777. UniProtKB:Q16777, 2-129, Arg-4, MOD:00077." [PRO:DNx, Reactome:R-HSA-5244589] comment: Category=organism-modification. synonym: "hHIST2H2AC/InitMet-/Me2a:5" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000055238, Arg-4, MOD:00077" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:Q16777, 2-129, Arg-4, MOD:00077" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-5244589 "PR:000047841 located_in GO:0005654" is_a: PR:Q16777 ! histone H2A type 2-C (human) relationship: has_part MOD:00077 ! asymmetric dimethyl-L-arginine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: lacks_part PR:000021937 ! initiator methionine [Term] id: PR:000047835 name: histone H2A type 2-C, initiator methionine removed omega-methylated 1 (human) def: "A histone H2A type 2-C (human) that has had the initiator methionine removed and has been post-translationally modified to include omega-methyl-L-arginine at position 12 of the amino acid sequence represented by UniProtKB:Q16777. UniProtKB:Q16777, 2-129, Arg-12, MOD:00078." [PRO:DNx, Reactome:R-HSA-5229227] comment: Category=organism-modification. synonym: "hHIST2H2AC/InitMet-/Me1o:1" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000055238, Arg-12, MOD:00078" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:Q16777, 2-129, Arg-12, MOD:00078" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-5229227 "PR:000047835 located_in GO:0005654" is_a: PR:Q16777 ! histone H2A type 2-C (human) relationship: has_part MOD:00078 ! omega-N-methyl-L-arginine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: lacks_part PR:000021937 ! initiator methionine [Term] id: PR:000044998 name: histone H2A type 2-C, initiator methionine removed acetylated 1 (human) def: "A histone H2A type 2-C (human) that has had the initiator methionine removed and that has been acetylated at the position equivalent to Lys-6 of the amino acid sequence represented by UniProtKB:Q16777. UniProtKB:Q16777, 2-129, Lys-6, MOD:00064." [HIstome_var_Hs:Histone_H2A_type_2-C, PMID:17709392, PRO:DAN, PRO:JPB, PRO:JR] comment: Category=organism-modification. synonym: "H2A_type_2-C:H2AK5ac" BROAD [HIstome_ptm_Hs:H2AK5ac] synonym: "hHIST2H2AC/InitMet-/Ac:1" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000055238, Lys-6, MOD:00064" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:Q16777, 2-129, Lys-6, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-4568572 "PR:000044998 located_in GO:0005654" xref: TDR:12481 is_a: PR:Q16777 ! histone H2A type 2-C (human) relationship: has_part MOD:00064 ! N6-acetyl-L-lysine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: lacks_part PR:000021937 ! initiator methionine [Term] id: PR:000044999 name: histone H2A type 2-C, initiator methionine removed ubiquitinated 1 (human) def: "A histone H2A type 2-C (human) that has had the initiator methionine removed and that has been ubiquitinated on the lysine at the position equivalent to Lys-120 of the amino acid sequence represented by UniProtKB:Q16777. UniProtKB:Q16777, 2-129, Lys-120, MOD:01148." [HIstome_var_Hs:Histone_H2A_type_2-C, PMID:15386022, PMID:18400894, PRO:DAN, PRO:JPB, PRO:JR] comment: Category=organism-modification. synonym: "H2A_type_2-C:H2AK119ub" BROAD [HIstome_ptm_Hs:H2AK119ub] synonym: "hHIST2H2AC/InitMet-/Ubiq:1" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000055238, Lys-120, MOD:01148" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:Q16777, 2-129, Lys-120, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-6782532 "PR:000044999 located_in GO:0005654" is_a: PR:Q16777 ! histone H2A type 2-C (human) relationship: has_part MOD:01148 ! ubiquitinylated lysine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: lacks_part PR:000021937 ! initiator methionine [Term] id: PR:000044996 name: histone H2A type 2-C, initiator methionine removed citrullinated 1 (human) def: "A histone H2A type 2-C (human) that has had the initiator methionine removed and that has been citrullinated at the position equivalent to Arg-4 of the amino acid sequence represented by UniProtKB:Q16777. UniProtKB:Q16777, 2-129, Arg-4, MOD:00219." [HIstome_var_Hs:Histone_H2A_type_2-C, PMID:15823041, PRO:DAN, PRO:JPB, PRO:JR] comment: Category=organism-modification. synonym: "H2A_type_2-C:H2AR3ci" BROAD [HIstome_ptm_Hs:H2AR3ci] synonym: "hHIST2H2AC/InitMet-/Cit:1" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000055238, Arg-4, MOD:00219" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:Q16777, 2-129, Arg-4, MOD:00219" EXACT PRO-proteoform-std [PRO:DNx] is_a: PR:Q16777 ! histone H2A type 2-C (human) relationship: has_part MOD:00219 ! L-citrulline relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: lacks_part PR:000021937 ! initiator methionine [Term] id: PR:000044997 name: histone H2A type 2-C, initiator methionine removed ADP-ribosylated 1 (human) def: "A histone H2A type 2-C (human) that has had the initiator methionine removed and that has been ADP-ribosylated at the position equivalent to Lys-14 of the amino acid sequence represented by UniProtKB:Q16777. UniProtKB:Q16777, 2-129, Lys-14, MOD:01399." [HIstome_var_Hs:Histone_H2A_type_2-C, PMID:20525793, PRO:DAN, PRO:JPB, PRO:JR] comment: Category=organism-modification. synonym: "H2A_type_2-C:H2AK13ar" BROAD [HIstome_ptm_Hs:H2AK13ar] synonym: "hHIST2H2AC/InitMet-/ADPrib:1" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000055238, Lys-14, MOD:01399" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:Q16777, 2-129, Lys-14, MOD:01399" EXACT PRO-proteoform-std [PRO:DNx] is_a: PR:Q16777 ! histone H2A type 2-C (human) relationship: has_part MOD:01399 ! N6-(ADP-ribosyl)-L-lysine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: lacks_part PR:000021937 ! initiator methionine [Term] id: PR:000008597 name: histone H2A type 2-C def: "A histone H2A that is a translation product of the human H2AC20 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "H2AFQ" RELATED Gene-based [] synonym: "H2AC20" EXACT PRO-short-label [PRO:DNx] synonym: "H2a-613B" EXACT [] synonym: "HIST2H2AC" RELATED Gene-based [] synonym: "Hist2h2ab" RELATED [] synonym: "histone H2A/q" EXACT [] synonym: "histone H2A-GL101" EXACT [] is_a: PR:000027547 ! histone H2A [Term] id: PR:000047842 name: histone H2A type 2-C, initiator methionine removed N6-acetyllysine form (human) def: "A histone H2A type 2-C (human) that has had the initiator methionine removed and that includes at least one N6-acetyllysine. UniProtKB:Q16777, 2-129, MOD:00064." [PRO:DNx, Reactome:R-HSA-4551338] comment: Category=organism-modification. synonym: "PRO_0000055238, MOD:00064" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "hHIST2H2AC/InitMet-/N6AcLys+" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q16777, 2-129, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-4551338 "PR:000047842 located_in GO:0005654" intersection_of: has_part MOD:00064 ! N6-acetyl-L-lysine intersection_of: lacks_part PR:000021937 ! initiator methionine intersection_of: PR:Q16777 ! histone H2A type 2-C (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000047840 name: histone H2A type 2-C, initiator methionine removed symmetrically-dimethylated 4 (human) def: "A histone H2A type 2-C (human) that has had the initiator methionine removed and has been post-translationally modified to include symmetric dimethyl-L-arginine at position 4 of the amino acid sequence represented by UniProtKB:Q16777. UniProtKB:Q16777, 2-129, Arg-4, MOD:00076." [PRO:DNx, Reactome:R-HSA-5218305] comment: Category=organism-modification. synonym: "hHIST2H2AC/InitMet-/Me2s:4" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000055238, Arg-4, MOD:00076" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:Q16777, 2-129, Arg-4, MOD:00076" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-5218305 "PR:000047840 located_in GO:0005654" is_a: PR:Q16777 ! histone H2A type 2-C (human) relationship: has_part MOD:00076 ! symmetric dimethyl-L-arginine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: lacks_part PR:000021937 ! initiator methionine