[Term]
id: PR:P62805
name: histone H4 (human)
def: "A histone H4 that is encoded in the genome of human." [PRO:DAN]
comment: Category=organism-gene. Note: The HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, and HIST4H4 genes encode identical proteins.
synonym: "hH4" EXACT PRO-short-label [PRO:DNx]
synonym: "H4/A" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4/B" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4/C" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4/D" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4/E" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4/G" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4/H" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4/I" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4/J" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4/K" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4/M" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4/N" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4/O" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4C1" RELATED Gene-based [UniProtKB:P62805]
synonym: "H4C2" RELATED Gene-based [UniProtKB:P62805]
synonym: "H4C3" RELATED Gene-based [UniProtKB:P62805]
synonym: "H4C4" RELATED Gene-based [UniProtKB:P62805]
synonym: "H4C5" RELATED Gene-based [UniProtKB:P62805]
synonym: "H4C6" RELATED Gene-based [UniProtKB:P62805]
synonym: "H4C8" RELATED Gene-based [UniProtKB:P62805]
synonym: "H4C9" RELATED Gene-based [UniProtKB:P62805]
synonym: "H4F2" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4FA" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4FB" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4FC" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4FD" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4FE" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4FG" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4FH" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4FI" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4FJ" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4FK" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4FM" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4FN" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4FO" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "H4-16" RELATED Gene-based [UniProtKB:P62805]
synonym: "H4C11" RELATED Gene-based [UniProtKB:P62805]
synonym: "H4C12" RELATED Gene-based [UniProtKB:P62805]
synonym: "H4C13" RELATED Gene-based [UniProtKB:P62805]
synonym: "H4C14" RELATED Gene-based [UniProtKB:P62805]
synonym: "H4C15" RELATED Gene-based [UniProtKB:P62805]
synonym: "H4C16" RELATED Gene-based [UniProtKB:P62805]
synonym: "HIST2H4" RELATED Gene-based [UniProtKB:P62805]
synonym: "HIST4H4" RELATED Gene-based [UniProtKB:P62805]
synonym: "HIST1H4A" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "HIST1H4B" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "HIST1H4C" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "HIST1H4D" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "HIST1H4E" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "HIST1H4F" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "HIST1H4H" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "HIST1H4I" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "HIST1H4J" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "HIST1H4K" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "HIST1H4L" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "HIST2H4A" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
synonym: "HIST2H4B" NARROW Gene-based [PRO:DAN, UniProtKB:P62805]
xref: UniProtKB:P62805
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000008603 ! histone H4
relationship: has_gene_template HGNC:20510 ! HIST4H4 (human)
relationship: has_gene_template HGNC:29607 ! HIST2H4B (human)
relationship: has_gene_template HGNC:4781 ! HIST1H4A (human)
relationship: has_gene_template HGNC:4782 ! HIST1H4D (human)
relationship: has_gene_template HGNC:4783 ! HIST1H4F (human)
relationship: has_gene_template HGNC:4784 ! HIST1H4K (human)
relationship: has_gene_template HGNC:4785 ! HIST1H4J (human)
relationship: has_gene_template HGNC:4787 ! HIST1H4C (human)
relationship: has_gene_template HGNC:4788 ! HIST1H4H (human)
relationship: has_gene_template HGNC:4789 ! HIST1H4B (human)
relationship: has_gene_template HGNC:4790 ! HIST1H4E (human)
relationship: has_gene_template HGNC:4791 ! HIST1H4L (human)
relationship: has_gene_template HGNC:4793 ! HIST1H4I (human)
relationship: has_gene_template HGNC:4794 ! HIST2H4A (human)

[Term]
id: PR:000045317
name: histone H4, initiator methionine removed trimethylated 1 (human)
def: "A histone H4 (human) that has had the initiator methionine removed and that has been trimethylated at the position equivalent to Lys-21 of the amino acid sequence represented by UniProtKB:P62805. UniProtKB:P62805, 2-103, Lys-21, MOD:00083." [HIstome_var_Hs:Histone_H4, PMID:15145825, PMID:15765097, PMID:15765097, PMID:20018718, PMID:20495075, PMID:20843831, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H4:H4K20me3" BROAD [HIstome_ptm_Hs:H4K20me3]
synonym: "hH4/InitMet-/Me3:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000158320, Lys-21, MOD:00083" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P62805, 2-103, Lys-21, MOD:00083" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5651656 "PR:000045317 located_in GO:0005654"
xref: TDR:13072
is_a: PR:P62805 ! histone H4 (human)
relationship: has_part MOD:00083 ! N6,N6,N6-trimethyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045316
name: histone H4, initiator methionine removed dimethylated 1 (human)
def: "A histone H4 (human) that has had the initiator methionine removed and that has been dimethylated at the position equivalent to Lys-21 of the amino acid sequence represented by UniProtKB:P62805. UniProtKB:P62805, 2-103, Lys-21, MOD:00084." [HIstome_var_Hs:Histone_H4, PMID:15200950, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H4:H4K20me2" BROAD [HIstome_ptm_Hs:H4K20me2]
synonym: "hH4/InitMet-/Me2:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000158320, Lys-21, MOD:00084" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P62805, 2-103, Lys-21, MOD:00084" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5651652 "PR:000045316 located_in GO:0005654"
xref: TDR:12674
is_a: PR:P62805 ! histone H4 (human)
relationship: has_part MOD:00084 ! N6,N6-dimethyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045315
name: histone H4, initiator methionine removed ADP-ribosylated 1 (human)
def: "A histone H4 (human) that has had the initiator methionine removed and that has been ADP-ribosylated at the position equivalent to Lys-17 of the amino acid sequence represented by UniProtKB:P62805. UniProtKB:P62805, 2-103, Lys-17, MOD:01399." [HIstome_var_Hs:Histone_H4, PMID:1326536, PMID:1429884, PMID:2387872, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H4:H4K16ar" BROAD [HIstome_ptm_Hs:H4K16ar]
synonym: "hH4/InitMet-/ADPrib:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000158320, Lys-17, MOD:01399" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P62805, 2-103, Lys-17, MOD:01399" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P62805 ! histone H4 (human)
relationship: has_part MOD:01399 ! N6-(ADP-ribosyl)-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045319
name: histone H4, initiator methionine removed monomethylated 1 (human)
def: "A histone H4 (human) that has had the initiator methionine removed and that has been monomethylated at the position equivalent to Lys-21 of the amino acid sequence represented by UniProtKB:P62805. UniProtKB:P62805, 2-103, Lys-21, MOD:00085." [HIstome_var_Hs:Histone_H4, PMID:15200950, PMID:16517599, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H4:H4K20me1" BROAD [HIstome_ptm_Hs:H4K20me1]
synonym: "hH4/InitMet-/Me1:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000158320, Lys-21, MOD:00085" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P62805, 2-103, Lys-21, MOD:00085" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-2172676 "PR:000045319 located_in GO:0005654"
xref: Reactome:R-HSA-5423110 "PR:000045319 located_in GO:0005654"
xref: TDR:12978
is_a: PR:P62805 ! histone H4 (human)
relationship: has_part MOD:00085 ! N6-methyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045318
name: histone H4, initiator methionine removed dimethylated 2 (human)
def: "A histone H4 (human) that has had the initiator methionine removed and that has been dimethylated at the position equivalent to Arg-4 of the amino acid sequence represented by UniProtKB:P62805. UniProtKB:P62805, 2-103, Arg-4, MOD:00783." [HIstome_var_Hs:Histone_H4, PMID:16103216, PMID:19234465, PMID:19234465, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H4:H4R3me2" BROAD [HIstome_ptm_Hs:H4R3me2]
synonym: "hH4/InitMet-/Me2:2" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000158320, Arg-4, MOD:00783" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P62805, 2-103, Arg-4, MOD:00783" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P62805 ! histone H4 (human)
relationship: has_part MOD:00783 ! dimethylated L-arginine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045330
name: histone H4, initiator methionine removed acetylated 5 (human)
def: "A histone H4 (human) that has had the initiator methionine removed and that has been acetylated at the position equivalent to Lys-9 of the amino acid sequence represented by UniProtKB:P62805. UniProtKB:P62805, 2-103, Lys-9, MOD:00064." [HIstome_var_Hs:Histone_H4, PMID:10958685, PMID:16387653, PMID:18552846, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H4:H4K8ac" BROAD [HIstome_ptm_Hs:H4K8ac]
synonym: "hH4/InitMet-/Ac:5" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000158320, Lys-9, MOD:00064" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P62805, 2-103, Lys-9, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-4568758 "PR:000045330 located_in GO:0005654"
is_a: PR:P62805 ! histone H4 (human)
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:P62805-1
name: histone H4 isoform 1 (human)
def: "A histone H4 isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hH4/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P62805-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000040025 ! histone H4 isoform 1

[Term]
id: PR:000008603
name: histone H4
def: "A core histone that is a translation product of the human HIST4H4 genes, 1:1 orthologs thereof, or a semi-ortholog thereof." [PRO:DAN]
comment: Category=gene. Note: The human The HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, and HIST4H4 genes encode identical proteins.
synonym: "H4" EXACT PRO-short-label [PRO:DNx]
synonym: "H4/A" RELATED Gene-based []
synonym: "H4/B" RELATED Gene-based []
synonym: "H4/C" RELATED Gene-based []
synonym: "H4/D" RELATED Gene-based []
synonym: "H4/E" RELATED Gene-based []
synonym: "H4/G" RELATED Gene-based []
synonym: "H4/H" RELATED Gene-based []
synonym: "H4/I" RELATED Gene-based []
synonym: "H4/J" RELATED Gene-based []
synonym: "H4/K" RELATED Gene-based []
synonym: "H4/M" RELATED Gene-based []
synonym: "H4/N" RELATED Gene-based []
synonym: "H4/O" RELATED Gene-based []
synonym: "H4C1" RELATED Gene-based []
synonym: "H4C2" RELATED Gene-based []
synonym: "H4C3" RELATED Gene-based []
synonym: "H4C4" RELATED Gene-based []
synonym: "H4C5" RELATED Gene-based []
synonym: "H4C6" RELATED Gene-based []
synonym: "H4C8" RELATED Gene-based []
synonym: "H4C9" RELATED Gene-based []
synonym: "H4F2" RELATED Gene-based []
synonym: "H4FA" RELATED Gene-based []
synonym: "H4FB" RELATED Gene-based []
synonym: "H4FC" RELATED Gene-based []
synonym: "H4FD" RELATED Gene-based []
synonym: "H4FE" RELATED Gene-based []
synonym: "H4FG" RELATED Gene-based []
synonym: "H4FH" RELATED Gene-based []
synonym: "H4FI" RELATED Gene-based []
synonym: "H4FJ" RELATED Gene-based []
synonym: "H4FK" RELATED Gene-based []
synonym: "H4FM" RELATED Gene-based []
synonym: "H4FN" RELATED Gene-based []
synonym: "H4FO" RELATED Gene-based []
synonym: "H4-16" RELATED Gene-based []
synonym: "H4C11" RELATED Gene-based []
synonym: "H4C12" RELATED Gene-based []
synonym: "H4C13" RELATED Gene-based []
synonym: "H4C14" RELATED Gene-based []
synonym: "H4C15" RELATED Gene-based []
synonym: "H4C16" RELATED Gene-based []
synonym: "HIST2H4" RELATED Gene-based []
synonym: "HIST4H4" RELATED Gene-based []
synonym: "HIST1H4A" RELATED Gene-based []
synonym: "HIST1H4B" RELATED Gene-based []
synonym: "HIST1H4C" RELATED Gene-based []
synonym: "HIST1H4D" RELATED Gene-based []
synonym: "HIST1H4E" RELATED Gene-based []
synonym: "HIST1H4F" RELATED Gene-based []
synonym: "HIST1H4H" RELATED Gene-based []
synonym: "HIST1H4I" RELATED Gene-based []
synonym: "HIST1H4J" RELATED Gene-based []
synonym: "HIST1H4K" RELATED Gene-based []
synonym: "HIST1H4L" RELATED Gene-based []
synonym: "HIST2H4A" RELATED Gene-based []
synonym: "HIST2H4B" RELATED Gene-based []
is_a: PR:000043452 ! core histone

[Term]
id: PR:000045328
name: histone H4, initiator methionine removed acetylated 3 (human)
def: "A histone H4 (human) that has had the initiator methionine removed and that has been acetylated at the position equivalent to Lys-13 of the amino acid sequence represented by UniProtKB:P62805. UniProtKB:P62805, 2-103, Lys-13, MOD:00064." [HIstome_var_Hs:Histone_H4, PMID:10958685, PMID:16387653, PMID:18552846, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H4:H4K12ac" BROAD [HIstome_ptm_Hs:H4K12ac]
synonym: "hH4/InitMet-/Ac:3" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000158320, Lys-13, MOD:00064" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P62805, 2-103, Lys-13, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-4568744 "PR:000045328 located_in GO:0005654"
is_a: PR:P62805 ! histone H4 (human)
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045329
name: histone H4, initiator methionine removed acetylated 4 (human)
def: "A histone H4 (human) that has had the initiator methionine removed and that has been acetylated at the position equivalent to Lys-6 of the amino acid sequence represented by UniProtKB:P62805. UniProtKB:P62805, 2-103, Lys-6, MOD:00064." [HIstome_var_Hs:Histone_H4, PMID:16387653, PMID:18552846, PMID:21272292, PMID:8343956, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H4:H4K5ac" BROAD [HIstome_ptm_Hs:H4K5ac]
synonym: "hH4/InitMet-/Ac:4" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000158320, Lys-6, MOD:00064" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P62805, 2-103, Lys-6, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-4568748 "PR:000045329 located_in GO:0005654"
is_a: PR:P62805 ! histone H4 (human)
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045326
name: histone H4, initiator methionine removed acetylated 2 (human)
def: "A histone H4 (human) that has had the initiator methionine removed and that has been acetylated at the position equivalent to Lys-92 of the amino acid sequence represented by UniProtKB:P62805. UniProtKB:P62805, 2-103, Lys-92, MOD:00064." [HIstome_var_Hs:Histone_H4, PMID:18552846, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H4:H4K91ac" BROAD [HIstome_ptm_Hs:H4K91ac]
synonym: "hH4/InitMet-/Ac:2" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000158320, Lys-92, MOD:00064" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P62805, 2-103, Lys-92, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P62805 ! histone H4 (human)
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045327
name: histone H4, initiator methionine removed citrullinated 1 (human)
def: "A histone H4 (human) that has had the initiator methionine removed and that has been citrullinated at the position equivalent to Arg-4 of the amino acid sequence represented by UniProtKB:P62805. UniProtKB:P62805, 2-103, Arg-4, MOD:00219." [HIstome_var_Hs:Histone_H4, PMID:15345777, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H4:H4R3ci" BROAD [HIstome_ptm_Hs:H4R3ci]
synonym: "hH4/InitMet-/Cit:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000158320, Arg-4, MOD:00219" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P62805, 2-103, Arg-4, MOD:00219" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P62805 ! histone H4 (human)
relationship: has_part MOD:00219 ! L-citrulline
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045324
name: histone H4, initiator methionine removed biotinylated 2 (human)
def: "A histone H4 (human) that has had the initiator methionine removed and that has been biotinylated at the position equivalent to Lys-9 of the amino acid sequence represented by UniProtKB:P62805. UniProtKB:P62805, 2-103, Lys-9, MOD:00126." [HIstome_var_Hs:Histone_H4, PMID:15153116, PMID:16772434, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H4:H4K8bio" BROAD [HIstome_ptm_Hs:H4K8bio]
synonym: "hH4/InitMet-/Btn:2" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000158320, Lys-9, MOD:00126" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P62805, 2-103, Lys-9, MOD:00126" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P62805 ! histone H4 (human)
relationship: has_part MOD:00126 ! N6-biotinyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045325
name: histone H4, initiator methionine removed ubiquitinated 1 (human)
def: "A histone H4 (human) that has had the initiator methionine removed and that has been ubiquitinated on the lysine at the position equivalent to Lys-92 of the amino acid sequence represented by UniProtKB:P62805. UniProtKB:P62805, 2-103, Lys-92, MOD:01148." [HIstome_var_Hs:Histone_H4, PMID:19818714, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H4:H4K91ub" BROAD [HIstome_ptm_Hs:H4K91ub]
synonym: "hH4/InitMet-/Ubiq:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000158320, Lys-92, MOD:01148" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P62805, 2-103, Lys-92, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P62805 ! histone H4 (human)
relationship: has_part MOD:01148 ! ubiquitinylated lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045322
name: histone H4, initiator methionine removed biotinylated 1 (human)
def: "A histone H4 (human) that has had the initiator methionine removed and that has been biotinylated at the position equivalent to Lys-13 of the amino acid sequence represented by UniProtKB:P62805. UniProtKB:P62805, 2-103, Lys-13, MOD:00126." [HIstome_var_Hs:Histone_H4, PMID:15153116, PMID:16772434, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H4:H4K12bio" BROAD [HIstome_ptm_Hs:H4K12bio]
synonym: "hH4/InitMet-/Btn:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000158320, Lys-13, MOD:00126" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P62805, 2-103, Lys-13, MOD:00126" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P62805 ! histone H4 (human)
relationship: has_part MOD:00126 ! N6-biotinyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045323
name: histone H4, initiator methionine removed acetylated 1 (human)
def: "A histone H4 (human) that has had the initiator methionine removed and that has been acetylated at the position equivalent to Lys-17 of the amino acid sequence represented by UniProtKB:P62805. UniProtKB:P62805, 2-103, Lys-17, MOD:00064." [HIstome_var_Hs:Histone_H4, PMID:15469825, PMID:15765097, PMID:15765097, PMID:18552846, PMID:20479123, PMID:20525793, PMID:21272292, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H4:H4K16ac" BROAD [HIstome_ptm_Hs:H4K16ac]
synonym: "hH4/InitMet-/Ac:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000158320, Lys-17, MOD:00064" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P62805, 2-103, Lys-17, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-427469 "PR:000045323 located_in GO:0005654"
xref: Reactome:R-HSA-4568749 "PR:000045323 located_in GO:0005654"
is_a: PR:P62805 ! histone H4 (human)
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045320
name: histone H4, initiator methionine removed phosphorylated 1 (human)
def: "A histone H4 (human) that has had the initiator methionine removed and that has been phosphorylated on the residue at the position equivalent to Ser-2 of the amino acid sequence represented by UniProtKB:P62805. UniProtKB:P62805, 2-103, Ser-2, MOD:00046." [HIstome_var_Hs:Histone_H4, PMID:15823538, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H4:H4S1ph" BROAD [HIstome_ptm_Hs:H4S1ph]
synonym: "hH4/InitMet-/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000158320, Ser-2, MOD:00046" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P62805, 2-103, Ser-2, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: TDR:12345
is_a: PR:P62805 ! histone H4 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045321
name: histone H4, initiator methionine removed monomethylated 2 (human)
def: "A histone H4 (human) that has had the initiator methionine removed and that has been monomethylated at the position equivalent to Arg-4 of the amino acid sequence represented by UniProtKB:P62805. UniProtKB:P62805, 2-103, Arg-4, MOD:00414." [HIstome_var_Hs:Histone_H4, PMID:11387442, PMID:16103216, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H4:H4R3me1" BROAD [HIstome_ptm_Hs:H4R3me1]
synonym: "hH4/InitMet-/Me1:2" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000158320, Arg-4, MOD:00414" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P62805, 2-103, Arg-4, MOD:00414" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P62805 ! histone H4 (human)
relationship: has_part MOD:00414 ! monomethylated L-arginine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine