[Term]
id: PR:Q9JHR7-1
name: insulin-degrading enzyme isoform 1 (mouse)
def: "An insulin-degrading enzyme isoform 1 that is encoded in the genome of mouse." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "mIDE/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9JHR7-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000038911 ! insulin-degrading enzyme isoform 1

[Term]
id: PR:P35559
name: insulin-degrading enzyme (rat)
def: "An insulin-degrading enzyme that is encoded in the genome of rat." [OMA:P35559, PANTHER:PTHR11851:SF64, PRO:DNx]
comment: Category=organism-gene.
synonym: "Ide" RELATED Gene-based [UniProtKB:P35559]
synonym: "rIDE" EXACT PRO-short-label [PRO:DNx]
synonym: "insulysin (rat)" EXACT [UniProtKB:P35559]
synonym: "insulinase (rat)" EXACT [UniProtKB:P35559]
synonym: "insulin protease (rat)" EXACT [UniProtKB:P35559]
xref: UniProtKB:P35559
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000008886 ! insulin-degrading enzyme
relationship: has_gene_template RGD:2861 ! Ide (rat)

[Term]
id: PR:000008886
name: insulin-degrading enzyme
def: "A protein that is a translation product of the human IDE gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "IDE" EXACT PRO-short-label [PRO:DNx]
synonym: "insulysin" EXACT []
synonym: "insulinase" EXACT []
synonym: "insulin protease" EXACT []
synonym: "abeta-degrading protease" EXACT []
xref: IUPHARobj:2371
is_a: PR:000000001 ! protein

[Term]
id: PR:P14735
name: insulin-degrading enzyme (human)
def: "An insulin-degrading enzyme that is encoded in the genome of human." [PRO:DNx, UniProtKB:P14735]
comment: Category=organism-gene.
synonym: "IDE" RELATED Gene-based [UniProtKB:P14735]
synonym: "hIDE" EXACT PRO-short-label [PRO:DNx]
synonym: "insulysin (human)" EXACT [UniProtKB:P14735]
synonym: "insulinase (human)" EXACT [UniProtKB:P14735]
synonym: "insulin protease (human)" EXACT [UniProtKB:P14735]
synonym: "abeta-degrading protease (human)" EXACT [UniProtKB:P14735]
xref: Reactome:R-HSA-5696861 "PR:P14735 located_in GO:0005741"
xref: Reactome:R-HSA-9033133 "PR:P14735 located_in GO:0005829"
xref: Reactome:R-HSA-9033157 "PR:P14735 located_in GO:0005782"
xref: UniProtKB:P14735
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000008886 ! insulin-degrading enzyme
relationship: has_gene_template HGNC:5381 ! IDE (human)

[Term]
id: PR:O14077
name: putative zinc protease mug138 (Schizosaccharomyces pombe 972h-)
def: "An insulin-degrading enzyme that is encoded in the genome of Schizosaccharomyces pombe 972h-." [OMA:O14077, PANTHER:PTHR11851:SF64, PRO:DNx]
comment: Category=organism-gene.
synonym: "mug138" RELATED Gene-based [UniProtKB:O14077]
synonym: "SPAC2E11.12c" RELATED Gene-based [UniProtKB:O14077]
synonym: "SPACUNK4.12c" RELATED Gene-based [UniProtKB:O14077]
synonym: "Spom972h-IDE" EXACT PRO-short-label [PRO:DNx]
synonym: "meiotically up-regulated gene 138 protein (Schizosaccharomyces pombe 972h-)" EXACT [UniProtKB:O14077]
xref: UniProtKB:O14077
intersection_of: only_in_taxon NCBITaxon:284812 ! Schizosaccharomyces pombe 972h-
intersection_of: PR:000008886 ! insulin-degrading enzyme
relationship: has_gene_template PomBase:SPACUNK4.12c ! mug138 (Schizosaccharomyces pombe)

[Term]
id: PR:P14735-2
name: insulin-degrading enzyme isoform h2 (human)
def: "An insulin-degrading enzyme (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P14735-2." [PRO:DNx, UniProtKB:P14735]
comment: Category=organism-sequence.
synonym: "hIDE/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P14735-2
is_a: PR:P14735 ! insulin-degrading enzyme (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P22817
name: insulin-degrading enzyme (fruit fly)
def: "An insulin-degrading enzyme that is encoded in the genome of fruit fly." [OMA:P22817, PANTHER:PTHR11851:SF64, PRO:DNx]
comment: Category=organism-gene.
synonym: "Ide" RELATED Gene-based [UniProtKB:P22817]
synonym: "CG5517" RELATED Gene-based [UniProtKB:P22817]
synonym: "fly-IDE" EXACT PRO-short-label [PRO:DNx]
synonym: "insulysin (fruit fly)" EXACT [UniProtKB:P22817]
synonym: "insulinase (fruit fly)" EXACT [UniProtKB:P22817]
synonym: "insulin protease (fruit fly)" EXACT [UniProtKB:P22817]
xref: UniProtKB:P22817
intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster
intersection_of: PR:000008886 ! insulin-degrading enzyme
relationship: has_gene_template FlyBase:FBgn0001247 ! Ide (fruit fly)

[Term]
id: PR:P14735-1
name: insulin-degrading enzyme isoform 1 (human)
def: "An insulin-degrading enzyme isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hIDE/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P14735-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000038911 ! insulin-degrading enzyme isoform 1

[Term]
id: PR:Q9JHR7
name: insulin-degrading enzyme (mouse)
def: "An insulin-degrading enzyme that is encoded in the genome of mouse." [OMA:Q9JHR7, PRO:DNx]
comment: Category=organism-gene.
synonym: "Ide" RELATED Gene-based [UniProtKB:Q9JHR7]
synonym: "mIDE" EXACT PRO-short-label [PRO:DNx]
synonym: "insulysin (mouse)" EXACT [UniProtKB:Q9JHR7]
synonym: "insulinase (mouse)" EXACT [UniProtKB:Q9JHR7]
synonym: "insulin protease (mouse)" EXACT [UniProtKB:Q9JHR7]
xref: UniProtKB:Q9JHR7
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000008886 ! insulin-degrading enzyme
relationship: has_gene_template MGI:96412 ! Ide (mouse)

[Term]
id: PR:P35559-1
name: insulin-degrading enzyme isoform 1 (rat)
def: "An insulin-degrading enzyme isoform 1 that is encoded in the genome of rat." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "rIDE/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P35559-1
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000038911 ! insulin-degrading enzyme isoform 1

[Term]
id: PR:Q06010
name: A-factor-processing enzyme (yeast)
def: "An insulin-degrading enzyme that is encoded in the genome of yeast." [OMA:Q06010, PANTHER:PTHR11851:SF64, PRO:DNx]
comment: Category=organism-gene.
synonym: "yIDE" EXACT PRO-short-label [PRO:DNx]
synonym: "STE23" RELATED Gene-based [UniProtKB:Q06010]
synonym: "YLR389C" RELATED Gene-based [UniProtKB:Q06010]
synonym: "L8084.12" RELATED Gene-based [UniProtKB:Q06010]
synonym: "insulin-degrading enzyme homolog (yeast)" EXACT [UniProtKB:Q06010]
xref: UniProtKB:Q06010
intersection_of: only_in_taxon NCBITaxon:559292 ! Saccharomyces cerevisiae S288C
intersection_of: PR:000008886 ! insulin-degrading enzyme
relationship: has_gene_template SGD:S000004381 ! STE23 (yeast)

[Term]
id: PR:000038911
name: insulin-degrading enzyme isoform 1
def: "An insulin-degrading enzyme that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P14735-1 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "IDE/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000008886 ! insulin-degrading enzyme

[Term]
id: PR:000047941
name: insulin-degrading enzyme ubiquitinated form (human)
def: "An insulin-degrading enzyme (human) that includes at least one ubiquitinated lysine. UniProtKB:P14735, MOD:01148." [PRO:DNx, Reactome:R-HSA-6783095]
comment: Category=organism-modification.
synonym: "hIDE/UbiqLys+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P14735, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-6783095 "PR:000047941 located_in GO:0005741"
intersection_of: has_part MOD:01148 ! ubiquitinylated lysine
intersection_of: PR:P14735 ! insulin-degrading enzyme (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000020229
name: insulin-degrading enzyme, initiator methionine removed form
def: "An insulin-degrading enzyme that has had the initiator methionine removed." [PRO:DNx]
comment: Category=modification.
synonym: "IDE/InitMet-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000008886 ! insulin-degrading enzyme
intersection_of: lacks_part PR:000021937 ! initiator methionine