[Term]
id: PR:P14735-1
name: insulin-degrading enzyme isoform 1 (human)
def: "An insulin-degrading enzyme isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hIDE/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P14735-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000038911 ! insulin-degrading enzyme isoform 1

[Term]
id: PR:P14735-2
name: insulin-degrading enzyme isoform h2 (human)
def: "An insulin-degrading enzyme (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P14735-2." [PRO:DNx, UniProtKB:P14735]
comment: Category=organism-sequence.
synonym: "hIDE/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P14735-2
is_a: PR:P14735 ! insulin-degrading enzyme (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000047941
name: insulin-degrading enzyme ubiquitinated form (human)
def: "An insulin-degrading enzyme (human) that includes at least one ubiquitinated lysine. UniProtKB:P14735, MOD:01148." [PRO:DNx, Reactome:R-HSA-6783095]
comment: Category=organism-modification.
synonym: "hIDE/UbiqLys+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P14735, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-6783095 "PR:000047941 located_in GO:0005741"
intersection_of: has_part MOD:01148 ! ubiquitinylated lysine
intersection_of: PR:P14735 ! insulin-degrading enzyme (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000008886
name: insulin-degrading enzyme
def: "A protein that is a translation product of the human IDE gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "IDE" EXACT PRO-short-label [PRO:DNx]
synonym: "insulysin" EXACT []
synonym: "insulinase" EXACT []
synonym: "insulin protease" EXACT []
synonym: "abeta-degrading protease" EXACT []
xref: IUPHARobj:2371
is_a: PR:000000001 ! protein

[Term]
id: PR:P14735
name: insulin-degrading enzyme (human)
def: "An insulin-degrading enzyme that is encoded in the genome of human." [PRO:DNx, UniProtKB:P14735]
comment: Category=organism-gene.
synonym: "IDE" RELATED Gene-based [UniProtKB:P14735]
synonym: "hIDE" EXACT PRO-short-label [PRO:DNx]
synonym: "insulysin (human)" EXACT [UniProtKB:P14735]
synonym: "insulinase (human)" EXACT [UniProtKB:P14735]
synonym: "insulin protease (human)" EXACT [UniProtKB:P14735]
synonym: "abeta-degrading protease (human)" EXACT [UniProtKB:P14735]
xref: Reactome:R-HSA-5696861 "PR:P14735 located_in GO:0005741"
xref: Reactome:R-HSA-9033133 "PR:P14735 located_in GO:0005829"
xref: Reactome:R-HSA-9033157 "PR:P14735 located_in GO:0005782"
xref: UniProtKB:P14735
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000008886 ! insulin-degrading enzyme
relationship: has_gene_template HGNC:5381 ! IDE (human)