[Term]
id: PR:000008949
name: insulin-like growth factor-binding protein 3
def: "A protein that is a translation product of the human IGFBP3 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "IBP3" RELATED Gene-based []
synonym: "IBP-3" EXACT []
synonym: "IGFBP3" EXACT PRO-short-label [PRO:DNx]
synonym: "IGFBP-3" EXACT []
synonym: "IGF-binding protein 3" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000047975
name: insulin-like growth factor-binding protein 3, signal peptide removed form (human)
def: "An insulin-like growth factor-binding protein 3 (human) that has had the signal peptide removed. UniProtKB:P17936, 28-291." [PRO:DNx, Reactome:R-HSA-381512]
comment: Category=organism-modification.
synonym: "PRO_0000014378" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hIGFBP3/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P17936, 28-291" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-381512 "PR:000047975 located_in GO:0005576"
xref: Reactome:R-HSA-8956748 "PR:000047975 located_in GO:0005788"
intersection_of: PR:P17936 ! insulin-like growth factor-binding protein 3 (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000055951
name: insulin-like growth factor-binding protein 3 N-glycosylated 1 (human)
def: "An insulin-like growth factor-binding protein 3 (human) that has been N-glycosylated at the residue equivalent to Asn-116 of the amino acid sequence represented by UniProtKB:P17936-1, in which the glycan composition is represented by GlyTouCan:G08293MJ. Example: UniProtKB:P17936-1, Asn-116, MOD:00160~GNO:G08293MJ." [GlyGen:P17936-1, PMID:29671580, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hIGFBP3/NGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P17936-1, Asn-116, MOD:00160~GNO:G08293MJ" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P17936 ! insulin-like growth factor-binding protein 3 (human)
relationship: has_part GNO:G08293MJ ! G08293MJ
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000055952
name: insulin-like growth factor-binding protein 3 N-glycosylated 2 (human)
def: "An insulin-like growth factor-binding protein 3 (human) that has been N-glycosylated at the residue equivalent to Asn-116 of the amino acid sequence represented by UniProtKB:P17936-1, in which the glycan composition is represented by GlyTouCan:G88374WZ. Example: UniProtKB:P17936-1, Asn-116, MOD:00160~GNO:G88374WZ." [GlyGen:P17936-1, PMID:29671580, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hIGFBP3/NGlyco:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P17936-1, Asn-116, MOD:00160~GNO:G88374WZ" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P17936 ! insulin-like growth factor-binding protein 3 (human)
relationship: has_part GNO:G88374WZ ! G88374WZ
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000055953
name: insulin-like growth factor-binding protein 3 N-glycosylated 3 (human)
def: "An insulin-like growth factor-binding protein 3 (human) that has been N-glycosylated at the residue equivalent to Asn-199 of the amino acid sequence represented by UniProtKB:P17936-1, in which the glycan composition is represented by GlyTouCan:G88374WZ. Example: UniProtKB:P17936-1, Asn-199, MOD:00160~GNO:G88374WZ." [GlyGen:P17936-1, PMID:29671580, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hIGFBP3/NGlyco:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P17936-1, Asn-199, MOD:00160~GNO:G88374WZ" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P17936 ! insulin-like growth factor-binding protein 3 (human)
relationship: has_part GNO:G88374WZ ! G88374WZ
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000055954
name: insulin-like growth factor-binding protein 3 O-glycosylated 1 (human)
def: "An insulin-like growth factor-binding protein 3 (human) that has been O-glycosylated at the residue equivalent to Ser-148 of the amino acid sequence represented by UniProtKB:P17936-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:P17936-1, Ser-148, MOD:00002~GNO:G29068FM." [GlyGen:P17936-1, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hIGFBP3/OGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P17936-1, Ser-148, MOD:00002~GNO:G29068FM" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P17936 ! insulin-like growth factor-binding protein 3 (human)
relationship: has_part GNO:G29068FM ! G29068FM
relationship: has_part MOD:00002 ! O-glycosyl-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000055955
name: insulin-like growth factor-binding protein 3 O-glycosylated 2 (human)
def: "An insulin-like growth factor-binding protein 3 (human) that has been O-glycosylated at the residue equivalent to Ser-148 of the amino acid sequence represented by UniProtKB:P17936-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P17936-1, Ser-148, MOD:00002~GNO:G43417UB." [GlyGen:P17936-1, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hIGFBP3/OGlyco:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P17936-1, Ser-148, MOD:00002~GNO:G43417UB" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P17936 ! insulin-like growth factor-binding protein 3 (human)
relationship: has_part GNO:G43417UB ! G43417UB
relationship: has_part MOD:00002 ! O-glycosyl-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000055956
name: insulin-like growth factor-binding protein 3 O-glycosylated 3 (human)
def: "An insulin-like growth factor-binding protein 3 (human) that has been O-glycosylated at the residue equivalent to Thr-195 of the amino acid sequence represented by UniProtKB:P17936-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P17936-1, Thr-195, MOD:00005~GNO:G43417UB." [GlyGen:P17936-1, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hIGFBP3/OGlyco:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P17936-1, Thr-195, MOD:00005~GNO:G43417UB" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P17936 ! insulin-like growth factor-binding protein 3 (human)
relationship: has_part GNO:G43417UB ! G43417UB
relationship: has_part MOD:00005 ! O-glycosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P17936
name: insulin-like growth factor-binding protein 3 (human)
def: "An insulin-like growth factor-binding protein 3 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P17936]
comment: Category=organism-gene.
synonym: "IBP3" RELATED Gene-based [UniProtKB:P17936]
synonym: "IGFBP3" RELATED Gene-based [UniProtKB:P17936]
synonym: "hIGFBP3" EXACT PRO-short-label [PRO:DNx]
synonym: "IBP-3 (human)" EXACT [UniProtKB:P17936]
synonym: "IGFBP-3 (human)" EXACT [UniProtKB:P17936]
synonym: "IGF-binding protein 3 (human)" EXACT [UniProtKB:P17936]
xref: UniProtKB:P17936
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000008949 ! insulin-like growth factor-binding protein 3
relationship: has_gene_template HGNC:5472 ! IGFBP3 (human)

[Term]
id: PR:P17936-2
name: insulin-like growth factor-binding protein 3 isoform h2 (human)
def: "An insulin-like growth factor-binding protein 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P17936-2." [PRO:DNx, UniProtKB:P17936]
comment: Category=organism-sequence.
synonym: "hIGFBP3/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P17936-2
is_a: PR:P17936 ! insulin-like growth factor-binding protein 3 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P17936-1
name: insulin-like growth factor-binding protein 3 isoform h1 (human)
def: "An insulin-like growth factor-binding protein 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P17936-1." [PRO:DNx, UniProtKB:P17936]
comment: Category=organism-sequence.
synonym: "hIGFBP3/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P17936-1
is_a: PR:P17936 ! insulin-like growth factor-binding protein 3 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens