[Term]
id: PR:000048067
name: integrin alpha-V, signal peptide removed form (human)
def: "An integrin alpha-V (human) that has had the signal peptide removed. UniProtKB:P06756, 31-1048." [PRO:DNx, Reactome:R-HSA-1236773, Reactome:R-HSA-210013]
comment: Category=organism-modification.
synonym: "PRO_0000016301" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hITGAV/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P06756, 31-1048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-210013 "PR:000048067 located_in GO:0005886"
xref: Reactome:R-HSA-1236773 "PR:000048067 located_in GO:0045335"
xref: Reactome:R-HSA-6806145 "PR:000048067 located_in GO:0035579"
intersection_of: PR:P06756 ! integrin alpha-V (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P06756-3
name: integrin alpha-V isoform h3 (human)
def: "An integrin alpha-V (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P06756-3." [PRO:DNx, UniProtKB:P06756]
comment: Category=organism-sequence.
synonym: "hITGAV/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P06756-3
is_a: PR:P06756 ! integrin alpha-V (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P06756
name: integrin alpha-V (human)
def: "An integrin alpha-V that is encoded in the genome of human." [PRO:DNx, UniProtKB:P06756]
comment: Category=organism-gene.
synonym: "MSK8" RELATED Gene-based [UniProtKB:P06756]
synonym: "VNRA" RELATED Gene-based [UniProtKB:P06756]
synonym: "VTNR" RELATED Gene-based [UniProtKB:P06756]
synonym: "ITGAV" RELATED Gene-based [UniProtKB:P06756]
synonym: "hITGAV" EXACT PRO-short-label [PRO:DNx]
synonym: "CD51 (human)" EXACT [UniProtKB:P06756]
synonym: "vitronectin receptor (human)" EXACT [UniProtKB:P06756]
synonym: "vitronectin receptor subunit alpha (human)" EXACT [UniProtKB:P06756]
xref: UniProtKB:P06756
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000009135 ! integrin alpha-V
relationship: has_gene_template HGNC:6150 ! ITGAV (human)

[Term]
id: PR:000009135
name: integrin alpha-V
def: "An integrin alpha lacking A domain that is a translation product of the human ITGAV gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "CD51" EXACT []
synonym: "MSK8" RELATED Gene-based []
synonym: "VNRA" RELATED Gene-based []
synonym: "VTNR" RELATED Gene-based []
synonym: "ITGAV" EXACT PRO-short-label [PRO:DNx]
synonym: "vitronectin receptor subunit alpha" EXACT []
xref: IUPHARobj:2453
is_a: PR:000025797 ! integrin alpha lacking A domain

[Term]
id: PR:P06756-1
name: integrin alpha-V isoform h1 (human)
def: "An integrin alpha-V (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P06756-1." [PRO:DNx, UniProtKB:P06756]
comment: Category=organism-sequence.
synonym: "hITGAV/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P06756-1
is_a: PR:P06756 ! integrin alpha-V (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000053594
name: integrin alpha-V N-glycosylated 1 (human)
def: "An integrin alpha-V (human) that has been N-glycosylated at the residue equivalent to Asn-615 of the amino acid sequence represented by UniProtKB:P06756-1, in which the glycan composition is represented by GlyTouCan:G25079LO. Example: UniProtKB:P06756-1, Asn-615, MOD:00160~GNO:G25079LO." [GlyGen:P06756-1, PMID:29741879, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hITGAV/NGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P06756-1, Asn-615, MOD:00160~GNO:G25079LO" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P06756 ! integrin alpha-V (human)
relationship: has_part GNO:G25079LO ! G25079LO
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000053595
name: integrin alpha-V N-glycosylated 2 (human)
def: "An integrin alpha-V (human) that has been N-glycosylated at the residue equivalent to Asn-74 of the amino acid sequence represented by UniProtKB:P06756-1, in which the glycan composition is represented by GlyTouCan:G03574QJ. Example: UniProtKB:P06756-1, Asn-74, MOD:00160~GNO:G03574QJ." [GlyGen:P06756-1, PMID:29741879, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hITGAV/NGlyco:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P06756-1, Asn-74, MOD:00160~GNO:G03574QJ" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P06756 ! integrin alpha-V (human)
relationship: has_part GNO:G03574QJ ! G03574QJ
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P06756-2
name: integrin alpha-V isoform h2 (human)
def: "An integrin alpha-V (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P06756-2." [PRO:DNx, UniProtKB:P06756]
comment: Category=organism-sequence.
synonym: "hITGAV/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P06756-2
is_a: PR:P06756 ! integrin alpha-V (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens