[Term]
id: PR:000009197
name: tyrosine-protein kinase JAK2
def: "A Janus kinase that is a translation product of the human JAK2 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "JAK2" EXACT PRO-short-label [PRO:DNx]
synonym: "JAK-2" EXACT []
synonym: "Janus kinase 2" EXACT []
xref: IUPHARobj:2048
is_a: PR:000025748 ! Janus kinase

[Term]
id: PR:000048085
name: tyrosine-protein kinase JAK2 phosphorylated 2 (human)
def: "A tyrosine-protein kinase JAK2 (human) that has been phosphorylated on the residue at the position equivalent to Tyr-1007 of the amino acid sequence represented by UniProtKB:O60674. UniProtKB:O60674, Tyr-1007, MOD:00048." [PRO:DNx, Reactome:R-HSA-873799]
comment: Category=organism-modification.
synonym: "hJAK2/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O60674, Tyr-1007, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-873799 "PR:000048085 located_in GO:0005829"
is_a: PR:O60674 ! tyrosine-protein kinase JAK2 (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000048086
name: tyrosine-protein kinase JAK2 phosphorylated 3 (human)
def: "A tyrosine-protein kinase JAK2 (human) that has been phosphorylated on the residue at the position equivalent to Tyr-813 of the amino acid sequence represented by UniProtKB:O60674. UniProtKB:O60674, Tyr-813, MOD:00048." [PRO:DNx, Reactome:R-HSA-997248]
comment: Category=organism-modification.
synonym: "hJAK2/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O60674, Tyr-813, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-997248 "PR:000048086 located_in GO:0005829"
is_a: PR:O60674 ! tyrosine-protein kinase JAK2 (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000048087
name: tyrosine-protein kinase JAK2 phosphorylated 4 (human)
def: "A tyrosine-protein kinase JAK2 (human) that has been post-translationally modified to include phosphotyrosine at positions 813, 868, 966, 972 and 1008 of the amino acid sequence represented by UniProtKB:O60674. UniProtKB:O60674, Tyr-813/Tyr-868/Tyr-966/Tyr-972/Tyr-1008, MOD:00048." [PRO:DNx, Reactome:R-HSA-2586516]
comment: Category=organism-modification.
synonym: "hJAK2/Phos:4" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O60674, Tyr-813/Tyr-868/Tyr-966/Tyr-972/Tyr-1008, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-2586516 "PR:000048087 located_in GO:0005829"
is_a: PR:O60674 ! tyrosine-protein kinase JAK2 (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000025747
name: tyrosine-protein kinase JAK2 isoform 1 phosphorylated 1 (human)
def: "A tyrosine-protein kinase JAK2 isoform 1 phosphorylated 1 in human. UniProtKB:O60674-1, Tyr-1007/Tyr-1008, MOD:00048." [OCA:JP, PDB:3E62, PDB:3E63, PDB:3E64, PMID:19019674]
comment: Category=organism-modification.
synonym: "hJAK2/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O60674-1, Tyr-1007/Tyr-1008, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000025746 ! tyrosine-protein kinase JAK2 isoform 1 phosphorylated 1
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:O60674
name: tyrosine-protein kinase JAK2 (human)
def: "A tyrosine-protein kinase JAK2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O60674]
comment: Category=organism-gene.
synonym: "JAK2" RELATED Gene-based [UniProtKB:O60674]
synonym: "hJAK2" EXACT PRO-short-label [PRO:DNx]
synonym: "JAK-2 (human)" EXACT [UniProtKB:O60674]
synonym: "Janus kinase 2 (human)" EXACT [UniProtKB:O60674]
xref: Reactome:R-HSA-210620 "PR:O60674 located_in GO:0005829"
xref: Reactome:R-HSA-2002372 "PR:O60674 located_in GO:0031904"
xref: DTO:03100197
xref: UniProtKB:O60674
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000009197 ! tyrosine-protein kinase JAK2
relationship: has_gene_template HGNC:6192 ! JAK2 (human)

[Term]
id: PR:O60674-1
name: tyrosine-protein kinase JAK2 isoform 1 (human)
def: "A tyrosine-protein kinase JAK2 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hJAK2/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O60674-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000025745 ! tyrosine-protein kinase JAK2 isoform 1