[Term]
id: PR:Q05469-2
name: hormone-sensitive lipase isoform h2 (human)
def: "A hormone-sensitive lipase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q05469-2." [PRO:DNx, UniProtKB:Q05469]
comment: Category=organism-sequence.
synonym: "hLIPE/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q05469-2
is_a: PR:Q05469 ! hormone-sensitive lipase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000009834
name: hormone-sensitive lipase
def: "A protein that is a translation product of the human LIPE gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "HSL" EXACT []
synonym: "LIPE" EXACT PRO-short-label [PRO:DNx]
synonym: "monoacylglycerol lipase LIPE" EXACT []
xref: IUPHARobj:2593
is_a: PR:000000001 ! protein

[Term]
id: PR:Q05469-1
name: hormone-sensitive lipase isoform h1 (human)
def: "A hormone-sensitive lipase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q05469-1." [PRO:DNx, UniProtKB:Q05469]
comment: Category=organism-sequence.
synonym: "hLIPE/iso:h1" EXACT PRO-short-label [PRO:DNx]
synonym: "hormone-sensitive lipase isoform Testicular (human)" EXACT [UniProtKB:Q05469]
xref: UniProtKB:Q05469-1
is_a: PR:Q05469 ! hormone-sensitive lipase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q05469
name: hormone-sensitive lipase (human)
def: "A hormone-sensitive lipase that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q05469]
comment: Category=organism-gene.
synonym: "LIPE" RELATED Gene-based [UniProtKB:Q05469]
synonym: "hLIPE" EXACT PRO-short-label [PRO:DNx]
synonym: "HSL (human)" EXACT [UniProtKB:Q05469]
synonym: "REH (human)" RELATED [UniProtKB:Q05469]
synonym: "retinyl ester hydrolase (human)" RELATED [UniProtKB:Q05469]
synonym: "monoacylglycerol lipase LIPE (human)" EXACT [UniProtKB:Q05469]
xref: Reactome:R-HSA-162503 "PR:Q05469 located_in GO:0005829"
xref: UniProtKB:Q05469
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000009834 ! hormone-sensitive lipase
relationship: has_gene_template HGNC:6621 ! LIPE (human)

[Term]
id: PR:000048216
name: hormone-sensitive lipase phosphorylated 1 (human)
def: "A hormone-sensitive lipase (human) that has been post-translationally modified to include phosphoserine at positions 950 and 951 of the amino acid sequence represented by UniProtKB:Q05469. UniProtKB:Q05469, Ser-950/Ser-951, MOD:00046." [PRO:DAN, Reactome:R-HSA-162472, Reactome:R-HSA-163467]
comment: Category=organism-modification. Note: The modified sites indicated here (Ser-950/Ser-951) are referred to as Ser-659/Ser-660 in the literature using the rat sequence. [PRO:DAN, PMID:9417067]
synonym: "hLIPE/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q05469, Ser-950/Ser-951, MOD:00046" EXACT PRO-proteoform-std [PRO:DAN]
xref: Reactome:R-HSA-162472 "PR:000048216 located_in GO:0005829"
xref: Reactome:R-HSA-163467 "PR:000048216 located_in GO:0005811"
is_a: PR:Q05469 ! hormone-sensitive lipase (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens