[Term]
id: PR:O14733
name: dual specificity mitogen-activated protein kinase kinase 7 (human)
def: "A dual specificity mitogen-activated protein kinase kinase 7 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O14733]
comment: Category=organism-gene.
synonym: "MEK7" RELATED Gene-based [UniProtKB:O14733]
synonym: "MKK7" RELATED Gene-based [UniProtKB:O14733]
synonym: "SKK4" RELATED Gene-based [UniProtKB:O14733]
synonym: "JNKK2" RELATED Gene-based [UniProtKB:O14733]
synonym: "MAP2K7" RELATED Gene-based [UniProtKB:O14733]
synonym: "PRKMK7" RELATED Gene-based [UniProtKB:O14733]
synonym: "hMAP2K7" EXACT PRO-short-label [PRO:DNx]
synonym: "MEK 7 (human)" EXACT [UniProtKB:O14733]
synonym: "JNKK 2 (human)" EXACT [UniProtKB:O14733]
synonym: "SAPKK4 (human)" EXACT [UniProtKB:O14733]
synonym: "MAPKK 7 (human)" EXACT [UniProtKB:O14733]
synonym: "SAPKK-4 (human)" EXACT [UniProtKB:O14733]
synonym: "JNK kinase 2 (human)" EXACT [UniProtKB:O14733]
synonym: "SAPK kinase 4 (human)" EXACT [UniProtKB:O14733]
synonym: "MAPK/ERK kinase 7 (human)" EXACT [UniProtKB:O14733]
synonym: "MAP kinase kinase 7 (human)" EXACT [UniProtKB:O14733]
synonym: "JNK-activating kinase 2 (human)" EXACT [UniProtKB:O14733]
synonym: "c-Jun N-terminal kinase kinase 2 (human)" EXACT [UniProtKB:O14733]
synonym: "stress-activated protein kinase kinase 4 (human)" EXACT [UniProtKB:O14733]
xref: Reactome:R-HSA-5211401 "PR:O14733 located_in GO:0005829"
xref: DTO:03100340
xref: UniProtKB:O14733
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000010128 ! dual specificity mitogen-activated protein kinase kinase 7
relationship: has_gene_template HGNC:6847 ! MAP2K7 (human)

[Term]
id: PR:O14733-3
name: dual specificity mitogen-activated protein kinase kinase 7 isoform 3 (human)
def: "A dual specificity mitogen-activated protein kinase kinase 7 isoform 3 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hMAP2K7/iso:3" EXACT PRO-short-label [PRO:DNx]
synonym: "dual specificity mitogen-activated protein kinase kinase 7 isoform gamma1 (human)" EXACT [UniProtKB:O14733]
xref: UniProtKB:O14733-3
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000037993 ! dual specificity mitogen-activated protein kinase kinase 7 isoform 3

[Term]
id: PR:000010128
name: dual specificity mitogen-activated protein kinase kinase 7
def: "A protein that is a translation product of the human MAP2K7 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "MEK7" RELATED Gene-based []
synonym: "MKK7" RELATED Gene-based []
synonym: "SKK4" RELATED Gene-based []
synonym: "JNKK2" RELATED Gene-based []
synonym: "MEK 7" EXACT []
synonym: "JNKK 2" EXACT []
synonym: "MAP2K7" EXACT PRO-short-label [PRO:DNx]
synonym: "PRKMK7" RELATED Gene-based []
synonym: "MAPKK 7" EXACT []
synonym: "JNK kinase 2" EXACT []
synonym: "MAPK/ERK kinase 7" EXACT []
synonym: "MAP kinase kinase 7" EXACT []
synonym: "JNK-activating kinase 2" EXACT []
synonym: "c-Jun N-terminal kinase kinase 2" EXACT []
xref: IUPHARobj:2068
is_a: PR:000000001 ! protein

[Term]
id: PR:O14733-4
name: dual specificity mitogen-activated protein kinase kinase 7 isoform h4 (human)
def: "A dual specificity mitogen-activated protein kinase kinase 7 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O14733-4." [PRO:DNx, UniProtKB:O14733]
comment: Category=organism-sequence.
synonym: "hMAP2K7/iso:h4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O14733-4
is_a: PR:O14733 ! dual specificity mitogen-activated protein kinase kinase 7 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000048300
name: dual specificity mitogen-activated protein kinase kinase 7, initiator methionine removed form (human)
def: "A dual specificity mitogen-activated protein kinase kinase 7 (human) that has had the initiator methionine removed. UniProtKB:O14733, 2-419." [PRO:DNx, Reactome:R-HSA-450276]
comment: Category=organism-modification.
synonym: "PRO_0000086388" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hMAP2K7/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O14733, 2-419" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-450276 "PR:000048300 located_in GO:0005829"
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:O14733 ! dual specificity mitogen-activated protein kinase kinase 7 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O14733-1
name: dual specificity mitogen-activated protein kinase kinase 7 isoform 1 (human)
def: "A dual specificity mitogen-activated protein kinase kinase 7 isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hMAP2K7/iso:1" EXACT PRO-short-label [PRO:DNx]
synonym: "dual specificity mitogen-activated protein kinase kinase 7 isoform A (human)" EXACT [UniProtKB:O14733]
xref: UniProtKB:O14733-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000037992 ! dual specificity mitogen-activated protein kinase kinase 7 isoform 1

[Term]
id: PR:000048301
name: dual specificity mitogen-activated protein kinase kinase 7 phosphorylated 1 (human)
def: "A dual specificity mitogen-activated protein kinase kinase 7 (human) that has been phosphorylated on the residue at the position equivalent to Ser-271, and phosphothreonine at position 275 of the amino acid sequence represented by UniProtKB:O14733. UniProtKB:O14733, Ser-271, MOD:00046|Thr-275, MOD:00047." [PRO:DNx, Reactome:R-HSA-450353]
comment: Category=organism-modification.
synonym: "hMAP2K7/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O14733, Ser-271, MOD:00046|Thr-275, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-450353 "PR:000048301 located_in GO:0005829"
is_a: PR:O14733 ! dual specificity mitogen-activated protein kinase kinase 7 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O14733-2
name: dual specificity mitogen-activated protein kinase kinase 7 isoform h2 (human)
def: "A dual specificity mitogen-activated protein kinase kinase 7 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O14733-2." [PRO:DNx, UniProtKB:O14733]
comment: Category=organism-sequence.
synonym: "hMAP2K7/iso:h2" EXACT PRO-short-label [PRO:DNx]
synonym: "dual specificity mitogen-activated protein kinase kinase 7 isoform B (human)" EXACT [UniProtKB:O14733]
xref: UniProtKB:O14733-2
is_a: PR:O14733 ! dual specificity mitogen-activated protein kinase kinase 7 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens