[Term] id: PR:P41279-1 name: mitogen-activated protein kinase kinase kinase 8 isoform 1 (human) def: "A mitogen-activated protein kinase kinase kinase 8 isoform 1 that is encoded in the genome of human." [PRO:DNx] comment: Category=organism-sequence. synonym: "hMAP3K8/iso:1" EXACT PRO-short-label [PRO:DNx] synonym: "mitogen-activated protein kinase kinase kinase 8 isoform 58 kDa (human)" EXACT [UniProtKB:P41279] xref: UniProtKB:P41279-1 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000039424 ! mitogen-activated protein kinase kinase kinase 8 isoform 1 [Term] id: PR:P41279-2 name: mitogen-activated protein kinase kinase kinase 8 isoform h2 (human) def: "A mitogen-activated protein kinase kinase kinase 8 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P41279-2." [PRO:DNx, UniProtKB:P41279] comment: Category=organism-sequence. synonym: "hMAP3K8/iso:h2" EXACT PRO-short-label [PRO:DNx] synonym: "mitogen-activated protein kinase kinase kinase 8 isoform 52 kDa (human)" EXACT [UniProtKB:P41279] xref: UniProtKB:P41279-2 is_a: PR:P41279 ! mitogen-activated protein kinase kinase kinase 8 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000010140 name: mitogen-activated protein kinase kinase kinase 8 def: "A protein that is a translation product of the human MAP3K8 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "COT" RELATED Gene-based [] synonym: "ESTF" RELATED Gene-based [] synonym: "TPL-2" EXACT [] synonym: "MAP3K8" EXACT PRO-short-label [PRO:DNx] synonym: "proto-oncogene c-Cot" EXACT [] synonym: "tumor progression locus 2" EXACT [] synonym: "cancer Osaka thyroid oncogene" EXACT [] synonym: "serine/threonine-protein kinase cot" EXACT [] xref: IUPHARobj:2083 is_a: PR:000000001 ! protein [Term] id: PR:000045777 name: mitogen-activated protein kinase kinase kinase 8 phosphorylated 1 (human) def: "A mitogen-activated protein kinase kinase kinase 8 (human) that has been phosphorylated on the residue at the position equivalent to Thr-290 of the amino acid sequence represented by UniProtKB:P41279-1. Example: UniProtKB:P41279-1, Thr-290, MOD:00047." [PMID:15466476, PMID:15699325, iPTMnet:P41279] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:15466476, PMID:15699325). Status=unreviewed. synonym: "hMAP3K8/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P41279-1, Thr-290, MOD:00047" NARROW PRO-proteoform-std [PRO:DNx] is_a: PR:P41279 ! mitogen-activated protein kinase kinase kinase 8 (human) relationship: has_part MOD:00047 ! O-phospho-L-threonine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P41279 name: mitogen-activated protein kinase kinase kinase 8 (human) def: "A mitogen-activated protein kinase kinase kinase 8 that is encoded in the genome of human." [PRO:DNx] comment: Category=organism-gene. synonym: "COT" RELATED Gene-based [UniProtKB:P41279] synonym: "ESTF" RELATED Gene-based [UniProtKB:P41279] synonym: "MAP3K8" RELATED Gene-based [UniProtKB:P41279] synonym: "hMAP3K8" EXACT PRO-short-label [PRO:DNx] synonym: "TPL-2 (human)" EXACT [UniProtKB:P41279] synonym: "proto-oncogene c-Cot (human)" EXACT [UniProtKB:P41279] synonym: "tumor progression locus 2 (human)" EXACT [UniProtKB:P41279] synonym: "cancer Osaka thyroid oncogene (human)" EXACT [UniProtKB:P41279] synonym: "serine/threonine-protein kinase cot (human)" EXACT [UniProtKB:P41279] xref: Reactome:R-HSA-389388 "PR:P41279 located_in GO:0005829" xref: DTO:03100290 xref: UniProtKB:P41279 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000010140 ! mitogen-activated protein kinase kinase kinase 8 relationship: has_gene_template HGNC:6860 ! MAP3K8 (human) [Term] id: PR:000048311 name: mitogen-activated protein kinase kinase kinase 8 phosphorylated 2 (human) def: "A mitogen-activated protein kinase kinase kinase 8 (human) that has been phosphorylated on the residue at the position equivalent to Thr-290, and phosphoserine at position 400 of the amino acid sequence represented by UniProtKB:P41279. UniProtKB:P41279, Thr-290, MOD:00047|Ser-400, MOD:00046." [PRO:DNx, Reactome:R-HSA-5684259] comment: Category=organism-modification. synonym: "hMAP3K8/Phos:2" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P41279, Thr-290, MOD:00047|Ser-400, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-5684259 "PR:000048311 located_in GO:0005829" is_a: PR:P41279 ! mitogen-activated protein kinase kinase kinase 8 (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: has_part MOD:00047 ! O-phospho-L-threonine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens