[Term]
id: PR:P49137
name: MAP kinase-activated protein kinase 2 (human)
def: "A MAP kinase-activated protein kinase 2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P49137]
comment: Category=organism-gene.
synonym: "MAPKAPK2" RELATED Gene-based [UniProtKB:P49137]
synonym: "hMAPKAPK2" EXACT PRO-short-label [PRO:DNx]
synonym: "MK2 (human)" EXACT [UniProtKB:P49137]
synonym: "MK-2 (human)" EXACT [UniProtKB:P49137]
synonym: "MAPKAP-K2 (human)" EXACT [UniProtKB:P49137]
synonym: "MAPKAPK-2 (human)" EXACT [UniProtKB:P49137]
synonym: "MAPKAP kinase 2 (human)" EXACT [UniProtKB:P49137]
synonym: "MAPK-activated protein kinase 2 (human)" EXACT [UniProtKB:P49137]
xref: Reactome:R-HSA-187743 "PR:P49137 located_in GO:0005829"
xref: Reactome:R-HSA-450235 "PR:P49137 located_in GO:0005654"
xref: DTO:03100299
xref: UniProtKB:P49137
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000010165 ! MAP kinase-activated protein kinase 2
relationship: has_gene_template HGNC:6887 ! MAPKAPK2 (human)

[Term]
id: PR:P49137-1
name: MAP kinase-activated protein kinase 2 isoform h1 (human)
def: "A MAP kinase-activated protein kinase 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49137-1." [PRO:DNx, UniProtKB:P49137]
comment: Category=organism-sequence.
synonym: "hMAPKAPK2/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P49137-1
is_a: PR:P49137 ! MAP kinase-activated protein kinase 2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P49137-2
name: MAP kinase-activated protein kinase 2 isoform h2 (human)
def: "A MAP kinase-activated protein kinase 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49137-2." [PRO:DNx, UniProtKB:P49137]
comment: Category=organism-sequence.
synonym: "hMAPKAPK2/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P49137-2
is_a: PR:P49137 ! MAP kinase-activated protein kinase 2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P49138
name: MAP kinase-activated protein kinase 2 (mouse)
def: "A MAP kinase-activated protein kinase 2 that is encoded in the genome of mouse." [OMA:P49138, PRO:DNx]
comment: Category=organism-gene.
synonym: "Rps6kc1" RELATED Gene-based [UniProtKB:P49138]
synonym: "Mapkapk2" RELATED Gene-based [UniProtKB:P49138]
synonym: "mMAPKAPK2" EXACT PRO-short-label [PRO:DNx]
synonym: "MK2 (mouse)" RELATED [UniProtKB:P49138]
synonym: "MK-2 (mouse)" EXACT [UniProtKB:P49138]
synonym: "MAPKAP-K2 (mouse)" EXACT [UniProtKB:P49138]
synonym: "MAPKAPK-2 (mouse)" EXACT [UniProtKB:P49138]
synonym: "MAPKAP kinase 2 (mouse)" EXACT [UniProtKB:P49138]
synonym: "MAPK-activated protein kinase 2 (mouse)" EXACT [UniProtKB:P49138]
xref: UniProtKB:P49138
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000010165 ! MAP kinase-activated protein kinase 2
relationship: has_gene_template MGI:109298 ! Mapkapk2 (mouse)

[Term]
id: PR:000010165
name: MAP kinase-activated protein kinase 2
def: "A protein that is a translation product of the human MAPKAPK2 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "MK2" RELATED []
synonym: "MK-2" EXACT []
synonym: "Rps6kc1" RELATED Gene-based []
synonym: "MAPKAPK2" EXACT PRO-short-label [PRO:DNx]
synonym: "MAPKAP-K2" EXACT []
synonym: "MAPKAPK-2" EXACT []
synonym: "MAPKAP kinase 2" EXACT []
synonym: "MAPK-activated protein kinase 2" EXACT []
xref: IUPHARobj:2094
is_a: PR:000000001 ! protein

[Term]
id: PR:000048330
name: MAP kinase-activated protein kinase 2 phosphorylated 1 (human)
def: "A MAP kinase-activated protein kinase 2 (human) that has been phosphorylated on the residue at the position equivalent to Thr-222, and phosphoserine at position 272 of the amino acid sequence represented by UniProtKB:P49137. UniProtKB:P49137, Thr-222, MOD:00047|Ser-272, MOD:00046." [PRO:DNx, Reactome:R-HSA-199936]
comment: Category=organism-modification.
synonym: "hMAPKAPK2/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P49137, Thr-222, MOD:00047|Ser-272, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-199936 "PR:000048330 located_in GO:0005654"
is_a: PR:P49137 ! MAP kinase-activated protein kinase 2 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000048331
name: MAP kinase-activated protein kinase 2 phosphorylated 2 (human)
def: "A MAP kinase-activated protein kinase 2 (human) that has been post-translationally modified to include phosphothreonine at positions 222 and 334, and phosphoserine at position 272 of the amino acid sequence represented by UniProtKB:P49137. UniProtKB:P49137, Thr-222/Thr-334, MOD:00047|Ser-272, MOD:00046." [PRO:DNx, Reactome:R-HSA-187760, Reactome:R-HSA-450268]
comment: Category=organism-modification.
synonym: "hMAPKAPK2/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P49137, Thr-222/Thr-334, MOD:00047|Ser-272, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-187760 "PR:000048331 located_in GO:0005829"
xref: Reactome:R-HSA-450268 "PR:000048331 located_in GO:0005654"
is_a: PR:P49137 ! MAP kinase-activated protein kinase 2 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens