[Term]
id: PR:000010268
name: protein Mdm4
def: "A protein that is a translation product of the human MDM4 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "MDM4" EXACT PRO-short-label [PRO:DNx]
synonym: "MDMX" RELATED Gene-based []
synonym: "protein Mdmx" EXACT []
synonym: "double minute 4 protein" EXACT []
synonym: "p53-binding protein Mdm4" EXACT []
synonym: "mdm2-like p53-binding protein" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:O35618-1
name: protein Mdm4 isoform Long (mouse)
def: "A protein Mdm4 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O35618-1." [PRO:DNx, UniProtKB:O35618]
comment: Category=organism-sequence.
synonym: "mMDM4/iso:Long" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O35618-1
is_a: PR:O35618 ! protein Mdm4 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:O35618-2
name: protein Mdm4 isoform Short (mouse)
def: "A protein Mdm4 isoform 2 that is encoded in the genome of mouse." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "mMDM4/iso:Short" EXACT PRO-short-label [PRO:DNx]
synonym: "protein Mdm4 isoform MdmX-S (mouse)" EXACT [UniProtKB:O35618]
xref: UniProtKB:O35618-2
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000038047 ! protein Mdm4 isoform 2

[Term]
id: PR:000045578
name: protein Mdm4 phosphorylated 1 (human)
def: "A protein Mdm4 (human) that has been phosphorylated on the residue at the position equivalent to Ser-96 of the amino acid sequence represented by UniProtKB:O15151-1. Example: UniProtKB:O15151-1, Ser-96, MOD:00046." [PMID:15735705, iPTMnet:O15151]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:15735705). Status=unreviewed.
synonym: "hMDM4/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O15151-1, Ser-96, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:O15151 ! protein Mdm4 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O15151-4
name: protein Mdm4 isoform hHDMX211 (human)
def: "A protein Mdm4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O15151-4." [PRO:DNx, UniProtKB:O15151]
comment: Category=organism-sequence.
synonym: "hMDM4/iso:hHDMX211" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O15151-4
is_a: PR:O15151 ! protein Mdm4 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000038047
name: protein Mdm4 isoform 2
def: "A protein Mdm4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O15151-2 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "MDM4/iso:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000010268 ! protein Mdm4

[Term]
id: PR:000048363
name: protein Mdm4 ubiquitinated form (human)
def: "A protein Mdm4 (human) that includes at least one ubiquitinated lysine. UniProtKB:O15151, MOD:01148." [PRO:DNx, Reactome:R-HSA-6782502]
comment: Category=organism-modification.
synonym: "hMDM4/UbiqLys+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O15151, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-6782502 "PR:000048363 located_in GO:0005654"
intersection_of: has_part MOD:01148 ! ubiquitinylated lysine
intersection_of: PR:O15151 ! protein Mdm4 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000048362
name: protein Mdm4 phosphorylated 3 (human)
def: "A protein Mdm4 (human) that has been phosphorylated on the residue at the position equivalent to Ser-403 of the amino acid sequence represented by UniProtKB:O15151. UniProtKB:O15151, Ser-403, MOD:00046." [PRO:DNx, Reactome:R-HSA-349461]
comment: Category=organism-modification.
synonym: "hMDM4/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O15151, Ser-403, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-349461 "PR:000048362 located_in GO:0005654"
is_a: PR:O15151 ! protein Mdm4 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q99L86
name: protein Mdm4 isoform 1 (mouse)
def: "A protein Mdm4 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mMDM4/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q99L86
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000025835 ! protein Mdm4 isoform 1

[Term]
id: PR:O15151-1
name: protein Mdm4 isoform 1 (human)
def: "A protein Mdm4 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence. Requested by=PubChem.
synonym: "hMDM4/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O15151-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000025835 ! protein Mdm4 isoform 1

[Term]
id: PR:O15151-2
name: protein Mdm4 isoform 2 (human)
def: "A protein Mdm4 isoform 2 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hMDM4/iso:2" EXACT PRO-short-label [PRO:DNx]
synonym: "protein Mdm4 isoform MDMX-S (human)" EXACT [UniProtKB:O15151]
xref: UniProtKB:O15151-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000038047 ! protein Mdm4 isoform 2

[Term]
id: PR:O15151-3
name: protein Mdm4 isoform h3 (human)
def: "A protein Mdm4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O15151-3." [PRO:DNx, UniProtKB:O15151]
comment: Category=organism-sequence.
synonym: "hMDM4/iso:h3" EXACT PRO-short-label [PRO:DNx]
synonym: "protein Mdm4 isoform MDMX (human)" EXACT [UniProtKB:O15151]
xref: UniProtKB:O15151-3
is_a: PR:O15151 ! protein Mdm4 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q7ZUW7-1
name: protein Mdm4 isoform 1 (zebrafish)
def: "A protein Mdm4 (zebrafish) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q7ZUW7-1." [PRO:DNx, UniProtKB:Q7ZUW7]
comment: Category=organism-sequence.
synonym: "z-MDM4/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q7ZUW7-1
is_a: PR:Q7ZUW7 ! protein Mdm4 (zebrafish)
relationship: only_in_taxon NCBITaxon:7955 ! Danio rerio

[Term]
id: PR:O15151-5
name: protein Mdm4 isoform h5 (human)
def: "A protein Mdm4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O15151-5." [PRO:DNx, UniProtKB:O15151]
comment: Category=organism-sequence.
synonym: "hMDM4/iso:h5" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O15151-5
is_a: PR:O15151 ! protein Mdm4 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q7ZUW7-2
name: protein Mdm4 isoform 2 (zebrafish)
def: "A protein Mdm4 (zebrafish) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q7ZUW7-2." [PRO:DNx, UniProtKB:Q7ZUW7]
comment: Category=organism-sequence.
synonym: "z-MDM4/iso:2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q7ZUW7-2
is_a: PR:Q7ZUW7 ! protein Mdm4 (zebrafish)
relationship: only_in_taxon NCBITaxon:7955 ! Danio rerio

[Term]
id: PR:Q5XIN1-1
name: protein Mdm4 isoform 1 (rat)
def: "A protein Mdm4 isoform 1 that is encoded in the genome of rat." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "rMDM4/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q5XIN1-1
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000025835 ! protein Mdm4 isoform 1

[Term]
id: PR:Q5XIN1
name: protein Mdm4 (rat)
def: "A protein Mdm4 that is encoded in the genome of rat." [OMA:Q5XIN1, PRO:DNx]
comment: Category=organism-gene.
synonym: "Mdm4" RELATED Gene-based [UniProtKB:Q5XIN1]
synonym: "Mdmx" RELATED Gene-based [UniProtKB:Q5XIN1]
synonym: "rMDM4" EXACT PRO-short-label [PRO:DNx]
synonym: "protein Mdmx (rat)" EXACT [UniProtKB:Q5XIN1]
synonym: "double minute 4 protein (rat)" EXACT [UniProtKB:Q5XIN1]
synonym: "p53-binding protein Mdm4 (rat)" EXACT [UniProtKB:Q5XIN1]
synonym: "Mdm2-like p53-binding protein (rat)" EXACT [UniProtKB:Q5XIN1]
xref: UniProtKB:Q5XIN1
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000010268 ! protein Mdm4
relationship: has_gene_template RGD:1309306 ! Mdm4 (rat)

[Term]
id: PR:O35618
name: protein Mdm4 (mouse)
def: "A protein Mdm4 that is encoded in the genome of mouse." [OMA:O35618, PRO:DNx]
comment: Category=organism-gene.
synonym: "Mdm4" RELATED Gene-based [UniProtKB:O35618]
synonym: "Mdmx" RELATED Gene-based [UniProtKB:O35618]
synonym: "mMDM4" EXACT PRO-short-label [PRO:DNx]
synonym: "protein Mdmx (mouse)" EXACT [UniProtKB:O35618]
synonym: "double minute 4 protein (mouse)" EXACT [UniProtKB:O35618]
synonym: "p53-binding protein Mdm4 (mouse)" EXACT [UniProtKB:O35618]
synonym: "Mdm2-like p53-binding protein (mouse)" EXACT [UniProtKB:O35618]
xref: UniProtKB:O35618
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000010268 ! protein Mdm4
relationship: has_gene_template MGI:107934 ! Mdm4 (mouse)

[Term]
id: PR:Q7ZUW7
name: protein Mdm4 (zebrafish)
def: "A protein Mdm4 that is encoded in the genome of zebrafish." [PANTHER:PTHR10360:SF10, PRO:DNx]
comment: Category=organism-gene.
synonym: "mdm4" RELATED Gene-based [UniProtKB:Q7ZUW7]
synonym: "mdmx" RELATED Gene-based [UniProtKB:Q7ZUW7]
synonym: "z-MDM4" EXACT PRO-short-label [PRO:DNx]
synonym: "protein Mdmx (zebrafish)" EXACT [UniProtKB:Q7ZUW7]
synonym: "double minute 4 protein (zebrafish)" EXACT [UniProtKB:Q7ZUW7]
synonym: "p53-binding protein Mdm4 (zebrafish)" EXACT [UniProtKB:Q7ZUW7]
synonym: "Mdm2-like p53-binding protein (zebrafish)" EXACT [UniProtKB:Q7ZUW7]
xref: UniProtKB:Q7ZUW7
intersection_of: only_in_taxon NCBITaxon:7955 ! Danio rerio
intersection_of: PR:000010268 ! protein Mdm4
relationship: has_gene_template ZFIN:ZDB-GENE-030131-6872 ! mdm4 (zebrafish)

[Term]
id: PR:O15151
name: protein Mdm4 (human)
def: "A protein Mdm4 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O15151]
comment: Category=organism-gene.
synonym: "MDM4" RELATED Gene-based [UniProtKB:O15151]
synonym: "MDMX" RELATED Gene-based [UniProtKB:O15151]
synonym: "hMDM4" EXACT PRO-short-label [PRO:DNx]
synonym: "protein Mdmx (human)" EXACT [UniProtKB:O15151]
synonym: "double minute 4 protein (human)" EXACT [UniProtKB:O15151]
synonym: "p53-binding protein Mdm4 (human)" EXACT [UniProtKB:O15151]
synonym: "Mdm2-like p53-binding protein (human)" EXACT [UniProtKB:O15151]
xref: Reactome:R-HSA-349430 "PR:O15151 located_in GO:0005654"
xref: UniProtKB:O15151
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000010268 ! protein Mdm4
relationship: has_gene_template HGNC:6974 ! MDM4 (human)

[Term]
id: PR:000025836
name: protein Mdm4 isoform 1 phosphorylated and ubiquitinated 1
def: "A protein Mdm4 isoform 1 that has been phosphorylated by Chk2, and ubiquitinated by MDM2. Example: UniProtKB:O15151-1, Ser-367, MOD:00046|MOD:01148." [PMID:16511560, PRO:CNA, PRO:DAN]
comment: Category=modification.
synonym: "MDM4/iso:1/PhosUbiq:1" EXACT PRO-short-label [PRO:DNx]
synonym: "MDMX phosphorylated and ubiquitinated" EXACT []
is_a: PR:000025835 ! protein Mdm4 isoform 1
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:01148 ! ubiquitinylated lysine

[Term]
id: PR:000025837
name: protein Mdm4 isoform 1 phosphorylated and ubiquitinated 1 (human)
def: "A protein Mdm4 isoform 1 phosphorylated and ubiquitinated 1 in human. UniProtKB:O15151-1, Ser-367, MOD:00046|MOD:01148." [PMID:16511560, PRO:JAN]
comment: Category=organism-modification.
synonym: "hMDM4/iso:1/PhosUbiq:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O15151-1, Ser-367, MOD:00046|MOD:01148" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000025836 ! protein Mdm4 isoform 1 phosphorylated and ubiquitinated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:01148 ! ubiquitinylated lysine

[Term]
id: PR:000048361
name: protein Mdm4 phosphorylated 2 (human)
def: "A protein Mdm4 (human) that has been post-translationally modified to include phosphoserine at positions 342, 367 and 403 of the amino acid sequence represented by UniProtKB:O15151. UniProtKB:O15151, Ser-342/Ser-367/Ser-403, MOD:00046." [PRO:DNx, Reactome:R-HSA-349441]
comment: Category=organism-modification.
synonym: "hMDM4/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O15151, Ser-342/Ser-367/Ser-403, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-349441 "PR:000048361 located_in GO:0005654"
is_a: PR:O15151 ! protein Mdm4 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000025835
name: protein Mdm4 isoform 1
def: "A protein Mdm4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O15151-1 or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=sequence.
synonym: "MDM4/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000010268 ! protein Mdm4