[Term]
id: PR:000010369
name: mitofusin-1
def: "A protein that is a translation product of the human MFN1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "MFN1" EXACT PRO-short-label [PRO:DNx]
synonym: "Fzo homolog" EXACT []
synonym: "transmembrane GTPase MFN1" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:Q8R4Z9
name: mitofusin-1 (rat)
def: "A mitofusin-1 that is encoded in the genome of rat." [OMA:Q8R4Z9, PANTHER:PTHR10465:SF2, PRO:DNx]
comment: Category=organism-gene.
synonym: "Mfn1" RELATED Gene-based [UniProtKB:Q8R4Z9]
synonym: "Fzo1b" RELATED Gene-based [UniProtKB:Q8R4Z9]
synonym: "rMFN1" EXACT PRO-short-label [PRO:DNx]
synonym: "transmembrane GTPase MFN1 (rat)" EXACT [UniProtKB:Q8R4Z9]
synonym: "mitochondrial transmembrane GTPase FZO1B (rat)" EXACT [UniProtKB:Q8R4Z9]
xref: UniProtKB:Q8R4Z9
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000010369 ! mitofusin-1
relationship: has_gene_template RGD:621460 ! Mfn1 (rat)

[Term]
id: PR:000048376
name: mitofusin-1 ubiquitinated form (human)
def: "A mitofusin-1 (human) that includes at least one ubiquitinated lysine. UniProtKB:Q8IWA4, MOD:01148." [PRO:DNx, Reactome:R-HSA-5205679]
comment: Category=organism-modification.
synonym: "hMFN1/UbiqLys+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q8IWA4, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5205679 "PR:000048376 located_in GO:0005741"
intersection_of: has_part MOD:01148 ! ubiquitinylated lysine
intersection_of: PR:Q8IWA4 ! mitofusin-1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q7YU24-1
name: transmembrane GTPase Marf isoform 1 (fruit fly)
def: "A transmembrane GTPase Marf (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q7YU24-1." [PRO:DNx, UniProtKB:Q7YU24]
comment: Category=organism-sequence.
synonym: "fly-MFN1/iso:1" EXACT PRO-short-label [PRO:DNx]
synonym: "transmembrane GTPase Marf isoform B (fruit fly)" EXACT [UniProtKB:Q7YU24]
synonym: "transmembrane GTPase Marf isoform C (fruit fly)" EXACT [UniProtKB:Q7YU24]
xref: UniProtKB:Q7YU24-1
is_a: PR:Q7YU24 ! transmembrane GTPase Marf (fruit fly)
relationship: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster

[Term]
id: PR:Q7YU24-2
name: transmembrane GTPase Marf isoform 2 (fruit fly)
def: "A transmembrane GTPase Marf (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q7YU24-2." [PRO:DNx, UniProtKB:Q7YU24]
comment: Category=organism-sequence.
synonym: "fly-MFN1/iso:2" EXACT PRO-short-label [PRO:DNx]
synonym: "transmembrane GTPase Marf isoform D (fruit fly)" EXACT [UniProtKB:Q7YU24]
xref: UniProtKB:Q7YU24-2
is_a: PR:Q7YU24 ! transmembrane GTPase Marf (fruit fly)
relationship: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster

[Term]
id: PR:Q811U4
name: mitofusin-1 (mouse)
def: "A mitofusin-1 that is encoded in the genome of mouse." [OMA:Q811U4, PRO:DNx]
comment: Category=organism-gene.
synonym: "Mfn1" RELATED Gene-based [UniProtKB:Q811U4]
synonym: "mMFN1" EXACT PRO-short-label [PRO:DNx]
synonym: "transmembrane GTPase MFN1 (mouse)" EXACT [UniProtKB:Q811U4]
xref: UniProtKB:Q811U4
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000010369 ! mitofusin-1
relationship: has_gene_template MGI:1914664 ! Mfn1 (mouse)

[Term]
id: PR:Q8IWA4-1
name: mitofusin-1 isoform h1 (human)
def: "A mitofusin-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8IWA4-1." [PRO:DNx, UniProtKB:Q8IWA4]
comment: Category=organism-sequence.
synonym: "hMFN1/iso:h1" EXACT PRO-short-label [PRO:DNx]
synonym: "mitofusin-1 isoform TG741 (human)" EXACT [UniProtKB:Q8IWA4]
xref: UniProtKB:Q8IWA4-1
is_a: PR:Q8IWA4 ! mitofusin-1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q8IWA4-2
name: mitofusin-1 isoform h2 (human)
def: "A mitofusin-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8IWA4-2." [PRO:DNx, UniProtKB:Q8IWA4]
comment: Category=organism-sequence.
synonym: "hMFN1/iso:h2" EXACT PRO-short-label [PRO:DNx]
synonym: "mitofusin-1 isoform TG370 (human)" EXACT [UniProtKB:Q8IWA4]
xref: UniProtKB:Q8IWA4-2
is_a: PR:Q8IWA4 ! mitofusin-1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q23424
name: transmembrane GTPase fzo-1 (worm)
def: "A mitofusin-1 that is encoded in the genome of worm." [PRO:DNx]
comment: Category=organism-gene.
synonym: "fzo-1" RELATED Gene-based [UniProtKB:Q23424]
synonym: "ZK1248.14" RELATED Gene-based [UniProtKB:Q23424]
synonym: "MFN1 (worm)" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q23424
intersection_of: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans
intersection_of: PR:000010369 ! mitofusin-1
relationship: has_gene_template WormBase:WBGene00001509 ! fzo-1 (worm)

[Term]
id: PR:Q8IWA4
name: mitofusin-1 (human)
def: "A mitofusin-1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q8IWA4]
comment: Category=organism-gene.
synonym: "MFN1" RELATED Gene-based [UniProtKB:Q8IWA4]
synonym: "hMFN1" EXACT PRO-short-label [PRO:DNx]
synonym: "Fzo homolog (human)" EXACT [UniProtKB:Q8IWA4]
synonym: "transmembrane GTPase MFN1 (human)" EXACT [UniProtKB:Q8IWA4]
xref: Reactome:R-HSA-992745 "PR:Q8IWA4 located_in GO:0005741"
xref: UniProtKB:Q8IWA4
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000010369 ! mitofusin-1
relationship: has_gene_template HGNC:18262 ! MFN1 (human)

[Term]
id: PR:Q8R4Z9-1
name: mitofusin-1 isoform 1 (rat)
def: "A mitofusin-1 isoform 1 that is encoded in the genome of rat." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "rMFN1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8R4Z9-1
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000041476 ! mitofusin-1 isoform 1

[Term]
id: PR:Q811U4-1
name: mitofusin-1 isoform 1 (mouse)
def: "A mitofusin-1 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "mMFN1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q811U4-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000041476 ! mitofusin-1 isoform 1

[Term]
id: PR:000041476
name: mitofusin-1 isoform 1
def: "A mitofusin-1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q811U4-1 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "MFN1/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000010369 ! mitofusin-1

[Term]
id: PR:Q7YU24
name: transmembrane GTPase Marf (fruit fly)
def: "A mitofusin-1 that is encoded in the genome of fruit fly." [PRO:DNx]
comment: Category=organism-gene.
synonym: "Marf" RELATED Gene-based [UniProtKB:Q7YU24]
synonym: "dmfn" RELATED Gene-based [UniProtKB:Q7YU24]
synonym: "CG3869" RELATED Gene-based [UniProtKB:Q7YU24]
synonym: "fly-MFN1" EXACT PRO-short-label [PRO:DNx]
synonym: "mitofusin (fruit fly)" EXACT [UniProtKB:Q7YU24]
synonym: "mitochondrial assembly regulatory factor (fruit fly)" EXACT [UniProtKB:Q7YU24]
xref: UniProtKB:Q7YU24
intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster
intersection_of: PR:000010369 ! mitofusin-1
relationship: has_gene_template FlyBase:FBgn0029870 ! Marf (fruit fly)

[Term]
id: PR:Q8IWA4-3
name: mitofusin-1 isoform h3 (human)
def: "A mitofusin-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8IWA4-3." [PRO:DNx, UniProtKB:Q8IWA4]
comment: Category=organism-sequence.
synonym: "hMFN1/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8IWA4-3
is_a: PR:Q8IWA4 ! mitofusin-1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens