[Term]
id: PR:Q03164
name: histone-lysine N-methyltransferase 2A (human)
def: "A histone-lysine N-methyltransferase 2A that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q03164]
comment: Category=organism-gene.
synonym: "HRX" RELATED Gene-based [UniProtKB:Q03164]
synonym: "MLL" RELATED Gene-based [UniProtKB:Q03164]
synonym: "ALL1" RELATED Gene-based [UniProtKB:Q03164]
synonym: "HTRX" RELATED Gene-based [UniProtKB:Q03164]
synonym: "MLL1" RELATED Gene-based [UniProtKB:Q03164]
synonym: "TRX1" RELATED Gene-based [UniProtKB:Q03164]
synonym: "CXXC7" RELATED Gene-based [UniProtKB:Q03164]
synonym: "KMT2A" RELATED Gene-based [UniProtKB:Q03164]
synonym: "hKMT2A" EXACT PRO-short-label [PRO:DNx]
synonym: "ALL-1 (human)" EXACT [UniProtKB:Q03164]
synonym: "trithorax-like protein (human)" EXACT [UniProtKB:Q03164]
synonym: "zinc finger protein HRX (human)" EXACT [UniProtKB:Q03164]
synonym: "lysine N-methyltransferase 2A (human)" EXACT [UniProtKB:Q03164]
synonym: "CXXC-type zinc finger protein 7 (human)" EXACT [UniProtKB:Q03164]
synonym: "cysteine methyltransferase KMT2A (human)" EXACT [UniProtKB:Q03164]
synonym: "myeloid/lymphoid or mixed-lineage leukemia (human)" EXACT [UniProtKB:Q03164]
synonym: "myeloid/lymphoid or mixed-lineage leukemia protein 1 (human)" EXACT [UniProtKB:Q03164]
xref: Reactome:R-HSA-1183223 "PR:Q03164 located_in GO:0005654"
xref: UniProtKB:Q03164
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000010445 ! histone-lysine N-methyltransferase 2A
relationship: has_gene_template HGNC:7132 ! KMT2A (human)

[Term]
id: PR:Q03164-1
name: histone-lysine N-methyltransferase 2A isoform h1 (human)
def: "A histone-lysine N-methyltransferase 2A (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q03164-1." [PRO:DNx, UniProtKB:Q03164]
comment: Category=organism-sequence.
synonym: "hKMT2A/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q03164-1
is_a: PR:Q03164 ! histone-lysine N-methyltransferase 2A (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q03164-3
name: histone-lysine N-methyltransferase 2A isoform h3 (human)
def: "A histone-lysine N-methyltransferase 2A (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q03164-3." [PRO:DNx, UniProtKB:Q03164]
comment: Category=organism-sequence.
synonym: "hKMT2A/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q03164-3
is_a: PR:Q03164 ! histone-lysine N-methyltransferase 2A (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q03164-2
name: histone-lysine N-methyltransferase 2A isoform h2 (human)
def: "A histone-lysine N-methyltransferase 2A (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q03164-2." [PRO:DNx, UniProtKB:Q03164]
comment: Category=organism-sequence.
synonym: "hKMT2A/iso:h2" EXACT PRO-short-label [PRO:DNx]
synonym: "histone-lysine N-methyltransferase 2A isoform 14P-18B (human)" EXACT [UniProtKB:Q03164]
xref: UniProtKB:Q03164-2
is_a: PR:Q03164 ! histone-lysine N-methyltransferase 2A (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000056861
name: histone-lysine N-methyltransferase 2A N-glycosylated 1 (human)
def: "A histone-lysine N-methyltransferase 2A (human) that has been N-glycosylated at the residue equivalent to Asn-1601 of the amino acid sequence represented by UniProtKB:Q03164-1, in which the glycan composition is represented by GlyTouCan:G39446WN. Example: UniProtKB:Q03164-1, Asn-1601, MOD:00160~GNO:G39446WN." [GlyGen:Q03164-1, PMID:29671580, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hKMT2A/NGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q03164-1, Asn-1601, MOD:00160~GNO:G39446WN" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:Q03164 ! histone-lysine N-methyltransferase 2A (human)
relationship: has_part GNO:G39446WN ! G39446WN
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000010445
name: histone-lysine N-methyltransferase 2A
def: "A protein that is a translation product of the human KMT2A gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "HRX" RELATED Gene-based []
synonym: "MLL" RELATED Gene-based []
synonym: "ALL1" RELATED Gene-based []
synonym: "HTRX" RELATED Gene-based []
synonym: "MLL1" RELATED Gene-based []
synonym: "TRX1" RELATED Gene-based []
synonym: "ALL-1" EXACT []
synonym: "CXXC7" RELATED Gene-based []
synonym: "KMT2A" EXACT PRO-short-label [PRO:DNx]
synonym: "trithorax-like protein" EXACT []
synonym: "zinc finger protein HRX" EXACT []
synonym: "lysine N-methyltransferase 2A" EXACT []
synonym: "CXXC-type zinc finger protein 7" EXACT []
synonym: "cysteine methyltransferase KMT2A" EXACT []
synonym: "histone-lysine N-methyltransferase HRX" EXACT []
synonym: "myeloid/lymphoid or mixed-lineage leukemia" EXACT []
synonym: "myeloid/lymphoid or mixed-lineage leukemia protein 1" EXACT []
xref: IUPHARobj:2688
is_a: PR:000000001 ! protein