[Term] id: PR:P11586-1 name: C-1-tetrahydrofolate synthase, cytoplasmic isoform 1 (human) def: "A C-1-tetrahydrofolate synthase, cytoplasmic isoform 1 that is encoded in the genome of human." [PRO:DNx] comment: Category=organism-sequence. synonym: "hMTHFD1/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P11586-1 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000038850 ! C-1-tetrahydrofolate synthase, cytoplasmic isoform 1 [Term] id: PR:Q54G53 name: formate-dihydrofolate ligase (Dictyostelium discoideum) def: "A C-1-tetrahydrofolate synthase, cytoplasmic that is encoded in the genome of Dictyostelium discoideum." [PRO:DNx] comment: Category=organism-gene. synonym: "Dicty-MTHFD1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q54G53 intersection_of: only_in_taxon NCBITaxon:44689 ! Dictyostelium discoideum intersection_of: PR:000010722 ! C-1-tetrahydrofolate synthase, cytoplasmic relationship: has_gene_template dictyBase:DDB_G0290397 ! fthS (Dictyostelium discoideum) [Term] id: PR:O96553 name: C-1-tetrahydrofolate synthase, cytoplasmic (fruit fly) def: "A C-1-tetrahydrofolate synthase, cytoplasmic that is encoded in the genome of fruit fly." [PANTHER:PTHR10025:SF13, PRO:DNx] comment: Category=organism-gene. synonym: "pug" RELATED Gene-based [UniProtKB:O96553] synonym: "CG4067" RELATED Gene-based [UniProtKB:O96553] synonym: "fly-MTHFD1" EXACT PRO-short-label [PRO:DNx] synonym: "C1-THF synthase (fruit fly)" EXACT [UniProtKB:O96553] xref: UniProtKB:O96553 intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster intersection_of: PR:000010722 ! C-1-tetrahydrofolate synthase, cytoplasmic relationship: has_gene_template FlyBase:FBgn0020385 ! pug (fruit fly) [Term] id: PR:000038850 name: C-1-tetrahydrofolate synthase, cytoplasmic isoform 1 def: "A C-1-tetrahydrofolate synthase, cytoplasmic that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P11586-1 or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=sequence. synonym: "MTHFD1/iso:1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000010722 ! C-1-tetrahydrofolate synthase, cytoplasmic [Term] id: PR:P27653 name: C-1-tetrahydrofolate synthase, cytoplasmic (rat) def: "A C-1-tetrahydrofolate synthase, cytoplasmic that is encoded in the genome of rat." [PANTHER:PTHR10025:SF13, PRO:DNx] comment: Category=organism-gene. synonym: "Mthfd" RELATED Gene-based [UniProtKB:P27653] synonym: "Mthfd1" RELATED Gene-based [UniProtKB:P27653] synonym: "rMTHFD1" EXACT PRO-short-label [PRO:DNx] synonym: "C1-THF synthase (rat)" EXACT [UniProtKB:P27653] xref: UniProtKB:P27653 intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus intersection_of: PR:000010722 ! C-1-tetrahydrofolate synthase, cytoplasmic relationship: has_gene_template RGD:708531 ! Mthfd1 (rat) [Term] id: PR:Q9SPK5 name: formate--tetrahydrofolate ligase (Arabidopsis thaliana) def: "A C-1-tetrahydrofolate synthase, cytoplasmic that is encoded in the genome of Arabidopsis thaliana." [PRO:DNx] comment: Category=organism-gene. synonym: "THFS" RELATED Gene-based [UniProtKB:Q9SPK5] synonym: "F17J6.2" RELATED Gene-based [UniProtKB:Q9SPK5] synonym: "At-MTHFD1" EXACT PRO-short-label [PRO:DNx] synonym: "At1g50480" RELATED Gene-based [UniProtKB:Q9SPK5] synonym: "F11F12.17" RELATED Gene-based [UniProtKB:Q9SPK5] synonym: "FHS (Arabidopsis thaliana)" EXACT [UniProtKB:Q9SPK5] synonym: "FTHFS (Arabidopsis thaliana)" EXACT [UniProtKB:Q9SPK5] synonym: "formyltetrahydrofolate synthetase (Arabidopsis thaliana)" EXACT [UniProtKB:Q9SPK5] synonym: "10-formyletrahydrofolate synthetase (Arabidopsis thaliana)" EXACT [UniProtKB:Q9SPK5] xref: UniProtKB:Q9SPK5 intersection_of: only_in_taxon NCBITaxon:3702 ! Arabidopsis thaliana intersection_of: PR:000010722 ! C-1-tetrahydrofolate synthase, cytoplasmic relationship: has_gene_template Araport:AT1G50480 ! THFS (Arabidopsis thaliana) [Term] id: PR:P27653-1 name: C-1-tetrahydrofolate synthase, cytoplasmic isoform 1 (rat) def: "A C-1-tetrahydrofolate synthase, cytoplasmic isoform 1 that is encoded in the genome of rat." [PRO:DNx] comment: Category=organism-sequence. synonym: "rMTHFD1/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P27653-1 intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus intersection_of: PR:000038850 ! C-1-tetrahydrofolate synthase, cytoplasmic isoform 1 [Term] id: PR:000048468 name: C-1-tetrahydrofolate synthase, cytoplasmic, initiator methionine removed form (human) def: "A C-1-tetrahydrofolate synthase, cytoplasmic (human) that has had the initiator methionine removed. UniProtKB:P11586, 2-935." [PRO:DNx, Reactome:R-HSA-200641] comment: Category=organism-modification. synonym: "PRO_0000199321" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "hMTHFD1/InitMet-" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P11586, 2-935" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-200641 "PR:000048468 located_in GO:0005829" intersection_of: lacks_part PR:000021937 ! initiator methionine intersection_of: PR:P11586 ! C-1-tetrahydrofolate synthase, cytoplasmic (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000020644 name: C-1-tetrahydrofolate synthase, cytoplasmic, initiator methionine removed form def: "A C-1-tetrahydrofolate synthase, cytoplasmic that has had the initiator methionine removed." [PRO:DNx] comment: Category=modification. synonym: "MTHFD1/InitMet-" EXACT PRO-short-label [PRO:DNx] intersection_of: PR:000010722 ! C-1-tetrahydrofolate synthase, cytoplasmic intersection_of: lacks_part PR:000021937 ! initiator methionine [Term] id: PR:Q922D8 name: C-1-tetrahydrofolate synthase, cytoplasmic (mouse) def: "A C-1-tetrahydrofolate synthase, cytoplasmic that is encoded in the genome of mouse." [OMA:Q922D8, PRO:DNx] comment: Category=organism-gene. synonym: "Mthfd1" RELATED Gene-based [UniProtKB:Q922D8] synonym: "mMTHFD1" EXACT PRO-short-label [PRO:DNx] synonym: "C1-THF synthase (mouse)" EXACT [UniProtKB:Q922D8] xref: UniProtKB:Q922D8 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000010722 ! C-1-tetrahydrofolate synthase, cytoplasmic relationship: has_gene_template MGI:1342005 ! Mthfd1 (mouse) [Term] id: PR:P11586 name: C-1-tetrahydrofolate synthase, cytoplasmic (human) def: "A C-1-tetrahydrofolate synthase, cytoplasmic that is encoded in the genome of human." [PRO:DNx, UniProtKB:P11586] comment: Category=organism-gene. synonym: "MTHFC" RELATED Gene-based [UniProtKB:P11586] synonym: "MTHFD" RELATED Gene-based [UniProtKB:P11586] synonym: "MTHFD1" RELATED Gene-based [UniProtKB:P11586] synonym: "hMTHFD1" EXACT PRO-short-label [PRO:DNx] synonym: "C1-THF synthase (human)" EXACT [UniProtKB:P11586] synonym: "epididymis secretory sperm binding protein (human)" EXACT [UniProtKB:P11586] xref: UniProtKB:P11586 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000010722 ! C-1-tetrahydrofolate synthase, cytoplasmic relationship: has_gene_template HGNC:7432 ! MTHFD1 (human) [Term] id: PR:Q8WZJ7 name: C-1-tetrahydrofolate synthase, cytoplasmic (Schizosaccharomyces pombe 972h-) def: "A C-1-tetrahydrofolate synthase, cytoplasmic that is encoded in the genome of Schizosaccharomyces pombe 972h-." [PRO:DNx] comment: Category=organism-gene. synonym: "SPBC839.16" RELATED Gene-based [UniProtKB:Q8WZJ7] synonym: "Spom972h-MTHFD1" EXACT PRO-short-label [PRO:DNx] synonym: "C1-THF synthase (Schizosaccharomyces pombe 972h-)" RELATED [UniProtKB:Q8WZJ7] xref: UniProtKB:Q8WZJ7 intersection_of: only_in_taxon NCBITaxon:284812 ! Schizosaccharomyces pombe 972h- intersection_of: PR:000010722 ! C-1-tetrahydrofolate synthase, cytoplasmic relationship: has_gene_template PomBase:SPBC839.16 ! SPBC839.16 (Schizosaccharomyces pombe) [Term] id: PR:000010722 name: C-1-tetrahydrofolate synthase, cytoplasmic def: "A protein that is a translation product of the human MTHFD1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "MTHFC" RELATED Gene-based [] synonym: "MTHFD" RELATED Gene-based [] synonym: "MTHFD1" EXACT PRO-short-label [PRO:DNx] synonym: "C1-THF synthase" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:O96553-2 name: C-1-tetrahydrofolate synthase, cytoplasmic isoform A (fruit fly) def: "A C-1-tetrahydrofolate synthase, cytoplasmic (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O96553-2." [PRO:DNx, UniProtKB:O96553] comment: Category=organism-sequence. synonym: "fly-MTHFD1/iso:A" EXACT PRO-short-label [PRO:DNx] synonym: "C-1-tetrahydrofolate synthase, cytoplasmic isoform C (fruit fly)" EXACT [UniProtKB:O96553] xref: UniProtKB:O96553-2 is_a: PR:O96553 ! C-1-tetrahydrofolate synthase, cytoplasmic (fruit fly) relationship: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster [Term] id: PR:O96553-1 name: C-1-tetrahydrofolate synthase, cytoplasmic isoform B (fruit fly) def: "A C-1-tetrahydrofolate synthase, cytoplasmic (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O96553-1." [PRO:DNx, UniProtKB:O96553] comment: Category=organism-sequence. synonym: "fly-MTHFD1/iso:B" EXACT PRO-short-label [PRO:DNx] synonym: "C-1-tetrahydrofolate synthase, cytoplasmic isoform D (fruit fly)" EXACT [UniProtKB:O96553] xref: UniProtKB:O96553-1 is_a: PR:O96553 ! C-1-tetrahydrofolate synthase, cytoplasmic (fruit fly) relationship: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster [Term] id: PR:Q922D8-1 name: C-1-tetrahydrofolate synthase, cytoplasmic isoform 1 (mouse) def: "A C-1-tetrahydrofolate synthase, cytoplasmic isoform 1 that is encoded in the genome of mouse." [PRO:DNx] comment: Category=organism-sequence. synonym: "mMTHFD1/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q922D8-1 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000038850 ! C-1-tetrahydrofolate synthase, cytoplasmic isoform 1