[Term]
id: PR:P49914
name: 5-formyltetrahydrofolate cyclo-ligase (human)
def: "A 5-formyltetrahydrofolate cyclo-ligase MTHFS that is encoded in the genome of human." [PRO:DNx, UniProtKB:P49914]
comment: Category=organism-gene.
synonym: "MTHFS" RELATED Gene-based [UniProtKB:P49914]
synonym: "hMTHFS" EXACT PRO-short-label [PRO:DNx]
synonym: "methenyl-THF synthetase (human)" EXACT [UniProtKB:P49914]
synonym: "5,10-methenyl-tetrahydrofolate synthetase (human)" EXACT [UniProtKB:P49914]
xref: UniProtKB:P49914
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000010726 ! 5-formyltetrahydrofolate cyclo-ligase MTHFS
relationship: has_gene_template HGNC:7437 ! MTHFS (human)

[Term]
id: PR:P49914-1
name: 5-formyltetrahydrofolate cyclo-ligase isoform h1 (human)
def: "A 5-formyltetrahydrofolate cyclo-ligase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49914-1." [PRO:DNx, UniProtKB:P49914]
comment: Category=organism-sequence.
synonym: "hMTHFS/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P49914-1
is_a: PR:P49914 ! 5-formyltetrahydrofolate cyclo-ligase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P49914-2
name: 5-formyltetrahydrofolate cyclo-ligase isoform h2 (human)
def: "A 5-formyltetrahydrofolate cyclo-ligase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49914-2." [PRO:DNx, UniProtKB:P49914]
comment: Category=organism-sequence.
synonym: "hMTHFS/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P49914-2
is_a: PR:P49914 ! 5-formyltetrahydrofolate cyclo-ligase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000048471
name: 5-formyltetrahydrofolate cyclo-ligase, initiator methionine removed form (human)
def: "A 5-formyltetrahydrofolate cyclo-ligase (human) that has had the initiator methionine removed. UniProtKB:P49914, 2-203." [PRO:DNx, Reactome:R-HSA-6801331]
comment: Category=organism-modification.
synonym: "PRO_0000200275" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hMTHFS/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P49914, 2-203" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-6801331 "PR:000048471 located_in GO:0005829"
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:P49914 ! 5-formyltetrahydrofolate cyclo-ligase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000010726
name: 5-formyltetrahydrofolate cyclo-ligase MTHFS
def: "A protein that is a translation product of the human MTHFS gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "MTHFS" EXACT PRO-short-label [PRO:DNx]
synonym: "methenyl-THF synthetase" EXACT []
synonym: "5,10-methenyl-tetrahydrofolate synthetase" EXACT []
is_a: PR:000000001 ! protein