[Term]
id: PR:Q12968
name: nuclear factor of activated T-cells, cytoplasmic 3 (human)
def: "A nuclear factor of activated T-cells, cytoplasmic 3 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q12968]
comment: Category=organism-gene.
synonym: "NFAT4" RELATED Gene-based [UniProtKB:Q12968]
synonym: "NFATC3" RELATED Gene-based [UniProtKB:Q12968]
synonym: "hNFATC3" EXACT PRO-short-label [PRO:DNx]
synonym: "NFATx (human)" EXACT [UniProtKB:Q12968]
synonym: "NF-AT4 (human)" EXACT [UniProtKB:Q12968]
synonym: "NFATc3 (human)" EXACT [UniProtKB:Q12968]
synonym: "NF-AT4c (human)" EXACT [UniProtKB:Q12968]
synonym: "NF-ATc3 (human)" EXACT [UniProtKB:Q12968]
synonym: "T-cell transcription factor NFAT4 (human)" EXACT [UniProtKB:Q12968]
xref: UniProtKB:Q12968
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000011166 ! nuclear factor of activated T-cells, cytoplasmic 3
relationship: has_gene_template HGNC:7777 ! NFATC3 (human)

[Term]
id: PR:Q12968-3
name: nuclear factor of activated T-cells, cytoplasmic 3 isoform h3 (human)
def: "A nuclear factor of activated T-cells, cytoplasmic 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12968-3." [PRO:DNx, UniProtKB:Q12968]
comment: Category=organism-sequence.
synonym: "hNFATC3/iso:h3" EXACT PRO-short-label [PRO:DNx]
synonym: "nuclear factor of activated T-cells, cytoplasmic 3 isoform X3 (human)" EXACT [UniProtKB:Q12968]
xref: UniProtKB:Q12968-3
is_a: PR:Q12968 ! nuclear factor of activated T-cells, cytoplasmic 3 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q12968-2
name: nuclear factor of activated T-cells, cytoplasmic 3 isoform h2 (human)
def: "A nuclear factor of activated T-cells, cytoplasmic 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12968-2." [PRO:DNx, UniProtKB:Q12968]
comment: Category=organism-sequence.
synonym: "hNFATC3/iso:h2" EXACT PRO-short-label [PRO:DNx]
synonym: "nuclear factor of activated T-cells, cytoplasmic 3 isoform C (human)" EXACT [UniProtKB:Q12968]
synonym: "nuclear factor of activated T-cells, cytoplasmic 3 isoform X2 (human)" EXACT [UniProtKB:Q12968]
xref: UniProtKB:Q12968-2
is_a: PR:Q12968 ! nuclear factor of activated T-cells, cytoplasmic 3 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q12968-1
name: nuclear factor of activated T-cells, cytoplasmic 3 isoform h1 (human)
def: "A nuclear factor of activated T-cells, cytoplasmic 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12968-1." [PRO:DNx, UniProtKB:Q12968]
comment: Category=organism-sequence.
synonym: "hNFATC3/iso:h1" EXACT PRO-short-label [PRO:DNx]
synonym: "nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 (human)" EXACT [UniProtKB:Q12968]
xref: UniProtKB:Q12968-1
is_a: PR:Q12968 ! nuclear factor of activated T-cells, cytoplasmic 3 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000048592
name: nuclear factor of activated T-cells, cytoplasmic 3, initiator methionine removed phosphorylated 1 (human)
def: "A nuclear factor of activated T-cells, cytoplasmic 3 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphoserine at positions 168, 169, 171, 172, 174, 236, 240, 244, 265, 288, 296, 300 and 344 of the amino acid sequence represented by UniProtKB:Q12968. UniProtKB:Q12968, 2-1075, Ser-168/Ser-169/Ser-171/Ser-172/Ser-174/Ser-236/Ser-240/Ser-244/Ser-265/Ser-288/Ser-296/Ser-300/Ser-344, MOD:00046." [PRO:DNx, Reactome:R-HSA-2025920]
comment: Category=organism-modification.
synonym: "hNFATC3/InitMet-/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000205180, Ser-168/Ser-169/Ser-171/Ser-172/Ser-174/Ser-236/Ser-240/Ser-244/Ser-265/Ser-288/Ser-296/Ser-300/Ser-344, MOD:00046" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q12968, 2-1075, Ser-168/Ser-169/Ser-171/Ser-172/Ser-174/Ser-236/Ser-240/Ser-244/Ser-265/Ser-288/Ser-296/Ser-300/Ser-344, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-2025920 "PR:000048592 located_in GO:0005829"
is_a: PR:Q12968 ! nuclear factor of activated T-cells, cytoplasmic 3 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000048593
name: nuclear factor of activated T-cells, cytoplasmic 3, initiator methionine removed phosphorylated 2 (human)
def: "A nuclear factor of activated T-cells, cytoplasmic 3 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphoserine at position 265 of the amino acid sequence represented by UniProtKB:Q12968. UniProtKB:Q12968, 2-1075, Ser-265, MOD:00046." [PRO:DNx, Reactome:R-HSA-2025988, Reactome:R-HSA-2685614]
comment: Category=organism-modification.
synonym: "hNFATC3/InitMet-/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000205180, Ser-265, MOD:00046" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q12968, 2-1075, Ser-265, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-2025988 "PR:000048593 located_in GO:0005654"
xref: Reactome:R-HSA-2685614 "PR:000048593 located_in GO:0005829"
is_a: PR:Q12968 ! nuclear factor of activated T-cells, cytoplasmic 3 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:Q12968-5
name: nuclear factor of activated T-cells, cytoplasmic 3 isoform h5 (human)
def: "A nuclear factor of activated T-cells, cytoplasmic 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12968-5." [PRO:DNx, UniProtKB:Q12968]
comment: Category=organism-sequence.
synonym: "hNFATC3/iso:h5" EXACT PRO-short-label [PRO:DNx]
synonym: "nuclear factor of activated T-cells, cytoplasmic 3 isoform A (human)" EXACT [UniProtKB:Q12968]
xref: UniProtKB:Q12968-5
is_a: PR:Q12968 ! nuclear factor of activated T-cells, cytoplasmic 3 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q12968-4
name: nuclear factor of activated T-cells, cytoplasmic 3 isoform h4 (human)
def: "A nuclear factor of activated T-cells, cytoplasmic 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12968-4." [PRO:DNx, UniProtKB:Q12968]
comment: Category=organism-sequence.
synonym: "hNFATC3/iso:h4" EXACT PRO-short-label [PRO:DNx]
synonym: "nuclear factor of activated T-cells, cytoplasmic 3 isoform X4 (human)" EXACT [UniProtKB:Q12968]
xref: UniProtKB:Q12968-4
is_a: PR:Q12968 ! nuclear factor of activated T-cells, cytoplasmic 3 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q12968-6
name: nuclear factor of activated T-cells, cytoplasmic 3 isoform h6 (human)
def: "A nuclear factor of activated T-cells, cytoplasmic 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12968-6." [PRO:DNx, UniProtKB:Q12968]
comment: Category=organism-sequence.
synonym: "hNFATC3/iso:h6" EXACT PRO-short-label [PRO:DNx]
synonym: "nuclear factor of activated T-cells, cytoplasmic 3 isoform B (human)" EXACT [UniProtKB:Q12968]
xref: UniProtKB:Q12968-6
is_a: PR:Q12968 ! nuclear factor of activated T-cells, cytoplasmic 3 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000011166
name: nuclear factor of activated T-cells, cytoplasmic 3
def: "A protein that is a translation product of the human NFATC3 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "NFAT4" RELATED Gene-based []
synonym: "NFATx" EXACT []
synonym: "NF-AT4" EXACT []
synonym: "NFATC3" EXACT PRO-short-label [PRO:DNx]
synonym: "NFATc3" EXACT []
synonym: "NF-ATc3" EXACT []
synonym: "T-cell transcription factor NFAT4" EXACT []
is_a: PR:000000001 ! protein