[Term]
id: PR:000035598
name: nitric oxide synthase, endothelial phosphorylated 1
def: "A nitric oxide synthase, endothelial that has been phosphorylated on a residue equivalent to Ser-1176 of the amino acid sequence represented by UniProtKB:P70313. Example: UniProtKB:P70313, Ser-1176, MOD:00046." [PMID:20852044, PRO:KRC]
comment: Category=modification.
synonym: "NOS3/Phos:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000011328 ! nitric oxide synthase, endothelial
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000048622
name: nitric oxide synthase, endothelial, initiator methionine removed form (human)
def: "A nitric oxide synthase, endothelial (human) that has had the initiator methionine removed. UniProtKB:P29474, 2-1203." [PRO:DNx, Reactome:R-HSA-202114]
comment: Category=organism-modification.
synonym: "PRO_0000170943" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hNOS3/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P29474, 2-1203" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-202114 "PR:000048622 located_in GO:0005829"
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:P29474 ! nitric oxide synthase, endothelial (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000035599
name: nitric oxide synthase, endothelial phosphorylated 1 (mouse)
def: "A nitric oxide synthase, endothelial phosphorylated 1 in mouse. UniProtKB:P70313, Ser-1176, MOD:00046." [PMID:20852044, PRO:KRC]
comment: Category=organism-modification.
synonym: "mNOS3/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P70313, Ser-1176, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000035598 ! nitric oxide synthase, endothelial phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:P29474-1
name: nitric oxide synthase, endothelial isoform h1 (human)
def: "A nitric oxide synthase, endothelial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P29474-1." [PRO:DNx, UniProtKB:P29474]
comment: Category=organism-sequence.
synonym: "hNOS3/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P29474-1
is_a: PR:P29474 ! nitric oxide synthase, endothelial (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P29474-2
name: nitric oxide synthase, endothelial isoform heNOS13C (human)
def: "A nitric oxide synthase, endothelial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P29474-2." [PRO:DNx, UniProtKB:P29474]
comment: Category=organism-sequence.
synonym: "hNOS3/iso:heNOS13C" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P29474-2
is_a: PR:P29474 ! nitric oxide synthase, endothelial (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P29474-3
name: nitric oxide synthase, endothelial isoform heNOS13B (human)
def: "A nitric oxide synthase, endothelial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P29474-3." [PRO:DNx, UniProtKB:P29474]
comment: Category=organism-sequence.
synonym: "hNOS3/iso:heNOS13B" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P29474-3
is_a: PR:P29474 ! nitric oxide synthase, endothelial (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q62600
name: nitric oxide synthase, endothelial (rat)
def: "A nitric oxide synthase, endothelial that is encoded in the genome of rat." [OMA:Q62600, PRO:DAN]
comment: Category=organism-gene. Requested by=PubChem.
synonym: "Nos3" RELATED Gene-based [UniProtKB:Q62600]
synonym: "rNOS3" EXACT PRO-short-label [PRO:DNx]
synonym: "cNOS (rat)" EXACT [UniProtKB:Q62600]
synonym: "eNOS (rat)" EXACT [UniProtKB:Q62600]
synonym: "EC-NOS (rat)" EXACT [UniProtKB:Q62600]
synonym: "NOSIII (rat)" EXACT [UniProtKB:Q62600]
synonym: "NOS type III (rat)" EXACT [UniProtKB:Q62600]
synonym: "endothelial NOS (rat)" EXACT [UniProtKB:Q62600]
synonym: "constitutive NOS (rat)" EXACT [UniProtKB:Q62600]
xref: UniProtKB:Q62600
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000011328 ! nitric oxide synthase, endothelial
relationship: has_gene_template RGD:3186 ! Nos3 (rat)

[Term]
id: PR:000011328
name: nitric oxide synthase, endothelial
def: "A protein that is a translation product of the human NOS3 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "NOS3" EXACT PRO-short-label [PRO:DNx]
synonym: "cNOS" EXACT []
synonym: "eNOS" EXACT []
synonym: "Ecnos" RELATED Gene-based []
synonym: "EC-NOS" EXACT []
synonym: "NOSIII" EXACT []
synonym: "NOS type III" EXACT []
synonym: "endothelial NOS" EXACT []
synonym: "constitutive NOS" BROAD [PRO:DNx]
xref: IUPHARobj:1249
is_a: PR:000000001 ! protein

[Term]
id: PR:000020762
name: nitric oxide synthase, endothelial, initiator methionine removed form
def: "A nitric oxide synthase, endothelial that has had the initiator methionine removed." [PRO:DNx]
comment: Category=modification.
synonym: "NOS3/InitMet-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000011328 ! nitric oxide synthase, endothelial
intersection_of: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045739
name: nitric oxide synthase, endothelial phosphorylated 1 (human)
def: "A nitric oxide synthase, endothelial (human) that has been phosphorylated on the residue at the position equivalent to Ser-1177 of the amino acid sequence represented by UniProtKB:P29474-1. Example: UniProtKB:P29474-1, Ser-1177, MOD:00046." [PMID:10376603, PMID:12446767, PMID:12791703, iPTMnet:P29474]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:10376603, PMID:12446767, PMID:12791703). Status=unreviewed.
synonym: "hNOS3/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P29474-1, Ser-1177, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P29474 ! nitric oxide synthase, endothelial (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P70313
name: nitric oxide synthase, endothelial (mouse)
def: "A nitric oxide synthase, endothelial that is encoded in the genome of mouse." [OMA:P70313, PRO:DNx]
comment: Category=organism-gene.
synonym: "Nos3" RELATED Gene-based [UniProtKB:P70313]
synonym: "Ecnos" RELATED Gene-based [UniProtKB:P70313]
synonym: "mNOS3" EXACT PRO-short-label [PRO:DNx]
synonym: "cNOS (mouse)" EXACT [UniProtKB:P70313]
synonym: "eNOS (mouse)" EXACT [UniProtKB:P70313]
synonym: "EC-NOS (mouse)" EXACT [UniProtKB:P70313]
synonym: "NOSIII (mouse)" EXACT [UniProtKB:P70313]
synonym: "NOS type III (mouse)" EXACT [UniProtKB:P70313]
synonym: "endothelial NOS (mouse)" EXACT [UniProtKB:P70313]
synonym: "constitutive NOS (mouse)" RELATED [UniProtKB:P70313]
xref: UniProtKB:P70313
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000011328 ! nitric oxide synthase, endothelial
relationship: has_gene_template MGI:97362 ! Nos3 (mouse)

[Term]
id: PR:000056330
name: nitric oxide synthase, endothelial O-glycosylated 1 (human)
def: "A nitric oxide synthase, endothelial (human) that has been O-glycosylated at the residue equivalent to Ser-78 of the amino acid sequence represented by UniProtKB:P29474-1, in which the glycan composition is represented by GlyTouCan:G58001LT. Example: UniProtKB:P29474-1, Ser-78, MOD:00002~GNO:G58001LT." [GlyGen:P29474-1, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hNOS3/OGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P29474-1, Ser-78, MOD:00002~GNO:G58001LT" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P29474 ! nitric oxide synthase, endothelial (human)
relationship: has_part GNO:G58001LT ! G58001LT
relationship: has_part MOD:00002 ! O-glycosyl-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P29474
name: nitric oxide synthase, endothelial (human)
def: "A nitric oxide synthase, endothelial that is encoded in the genome of human." [PRO:DNx, UniProtKB:P29474]
comment: Category=organism-gene.
synonym: "NOS3" RELATED Gene-based [UniProtKB:P29474]
synonym: "hNOS3" EXACT PRO-short-label [PRO:DNx]
synonym: "cNOS (human)" EXACT [UniProtKB:P29474]
synonym: "eNOS (human)" EXACT [UniProtKB:P29474]
synonym: "EC-NOS (human)" EXACT [UniProtKB:P29474]
synonym: "NOSIII (human)" EXACT [UniProtKB:P29474]
synonym: "NOS type III (human)" EXACT [UniProtKB:P29474]
synonym: "endothelial NOS (human)" EXACT [UniProtKB:P29474]
synonym: "constitutive NOS (human)" BROAD [UniProtKB:P29474]
xref: UniProtKB:P29474
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000011328 ! nitric oxide synthase, endothelial
relationship: has_gene_template HGNC:7876 ! NOS3 (human)