[Term] id: PR:000036307 name: nucleophosmin acetylated 1 (human) def: "A nucleophosmin that is N-terminal Met acetylated in human. Example: UniProtKB:P06748-1, Met-1, MOD:00058." [TDR:2341] comment: Category=organism-modification. Note: Top down proteomics. Evidence=(ECO:0000006). synonym: "hNPM1/Ac:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P06748-1, Met-1, MOD:00058" NARROW PRO-proteoform-std [PRO:DNx] xref: TDR:2341 is_a: PR:000011370 ! nucleophosmin relationship: has_part MOD:00058 ! N-acetyl-L-methionine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P06748-1 name: nucleophosmin isoform h1 (human) def: "A nucleophosmin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P06748-1." [PRO:DNx, UniProtKB:P06748] comment: Category=organism-sequence. synonym: "hNPM1/iso:h1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P06748-1 is_a: PR:P06748 ! nucleophosmin (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P06748-3 name: nucleophosmin isoform h3 (human) def: "A nucleophosmin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P06748-3." [PRO:DNx, UniProtKB:P06748] comment: Category=organism-sequence. synonym: "hNPM1/iso:h3" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P06748-3 is_a: PR:P06748 ! nucleophosmin (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P06748-2 name: nucleophosmin isoform h2 (human) def: "A nucleophosmin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P06748-2." [PRO:DNx, UniProtKB:P06748] comment: Category=organism-sequence. synonym: "hNPM1/iso:h2" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P06748-2 is_a: PR:P06748 ! nucleophosmin (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000048628 name: nucleophosmin phosphorylated 2 (human) def: "A nucleophosmin (human) that has been phosphorylated on the residue at the position equivalent to Ser-4 of the amino acid sequence represented by UniProtKB:P06748. UniProtKB:P06748, Ser-4, MOD:00046." [PRO:DNx, Reactome:R-HSA-6801679] comment: Category=organism-modification. synonym: "hNPM1/Phos:2" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P06748, Ser-4, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-6801679 "PR:000048628 located_in GO:0005829" is_a: PR:P06748 ! nucleophosmin (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000045648 name: nucleophosmin phosphorylated 1 (human) def: "A nucleophosmin (human) that has been phosphorylated on the residue at the position equivalent to Thr-199 of the amino acid sequence represented by UniProtKB:P06748-1. Example: UniProtKB:P06748-1, Thr-199, MOD:00047." [PMID:20333249, PMID:24998852, iPTMnet:P06748] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:20333249, PMID:24998852). Status=unreviewed. synonym: "hNPM1/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P06748-1, Thr-199, MOD:00047" NARROW PRO-proteoform-std [PRO:DNx] is_a: PR:P06748 ! nucleophosmin (human) relationship: has_part MOD:00047 ! O-phospho-L-threonine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000011370 name: nucleophosmin def: "A protein that is a translation product of the human NPM1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "NPM" RELATED Gene-based [] synonym: "NPM1" EXACT PRO-short-label [PRO:DNx] synonym: "numatrin" EXACT [] synonym: "nucleolar protein NO38" EXACT [] synonym: "nucleolar phosphoprotein B23" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:P06748 name: nucleophosmin (human) def: "A nucleophosmin that is encoded in the genome of human." [PRO:DNx, UniProtKB:P06748] comment: Category=organism-gene. synonym: "NPM" RELATED Gene-based [UniProtKB:P06748] synonym: "NPM1" RELATED Gene-based [UniProtKB:P06748] synonym: "hNPM1" EXACT PRO-short-label [PRO:DNx] synonym: "numatrin (human)" EXACT [UniProtKB:P06748] synonym: "nucleolar protein NO38 (human)" EXACT [UniProtKB:P06748] synonym: "nucleolar phosphoprotein B23 (human)" EXACT [UniProtKB:P06748] xref: Reactome:R-HSA-606320 "PR:P06748 located_in GO:0005654" xref: Reactome:R-HSA-3008211 "PR:P06748 located_in GO:0005829" xref: UniProtKB:P06748 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000011370 ! nucleophosmin relationship: has_gene_template HGNC:7910 ! NPM1 (human)