[Term] id: PR:P04629 name: high affinity nerve growth factor receptor (human) def: "A high affinity nerve growth factor receptor that is encoded in the genome of human." [PRO:DNx, UniProtKB:P04629] comment: Category=organism-gene. synonym: "MTC" RELATED Gene-based [UniProtKB:P04629] synonym: "TRK" RELATED Gene-based [UniProtKB:P04629] synonym: "TRKA" RELATED Gene-based [UniProtKB:P04629] synonym: "NTRK1" RELATED Gene-based [UniProtKB:P04629] synonym: "hNTRK1" EXACT PRO-short-label [PRO:DNx] synonym: "Trk-A (human)" EXACT [UniProtKB:P04629] synonym: "gp140trk (human)" EXACT [UniProtKB:P04629] synonym: "p140-TrkA (human)" EXACT [UniProtKB:P04629] synonym: "tyrosine kinase receptor (human)" EXACT [UniProtKB:P04629] synonym: "tyrosine kinase receptor A (human)" EXACT [UniProtKB:P04629] synonym: "tropomyosin-related kinase A (human)" EXACT [UniProtKB:P04629] synonym: "TRK1-transforming tyrosine kinase protein (human)" EXACT [UniProtKB:P04629] synonym: "neurotrophic tyrosine kinase receptor type 1 (human)" EXACT [UniProtKB:P04629] xref: DTO:03100371 xref: UniProtKB:P04629 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000011469 ! high affinity nerve growth factor receptor relationship: has_gene_template HGNC:8031 ! NTRK1 (human) [Term] id: PR:000011469 name: high affinity nerve growth factor receptor def: "A TRK receptor that is a translation product of the human NTRK1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "MTC" RELATED Gene-based [] synonym: "TRK" RELATED Gene-based [] synonym: "TRKA" RELATED Gene-based [] synonym: "NTRK1" EXACT PRO-short-label [PRO:DNx] synonym: "Trk-A" EXACT [] synonym: "p140-TrkA" EXACT [] synonym: "TRK1-transforming tyrosine kinase protein" EXACT [] synonym: "neurotrophic tyrosine kinase receptor type 1" EXACT [] xref: IUPHARobj:1817 is_a: PR:000021997 ! TRK receptor [Term] id: PR:000049960 name: high affinity nerve growth factor receptor isoform TrkA-I mature form unphosphorylated and N-glycosylated 2 (human) def: "A high affinity nerve growth factor receptor isoform TrkA-I (human) that has had the signal peptide removed, is N-glycosylated and lacks phosphotyrosine at positions Tyr-674 and Tyr-675. UniProtKB:P04629-2, 33-790, Tyr-674/Tyr-675, PR:000026291|MOD:00160." [PMID:27655914, PRO:LN] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:27655914). synonym: "hNTRK1/iso:TrkA-I/mature/UnPhosNGlyco:2" EXACT PRO-short-label [PRO:DAN] synonym: "UniProtKB:P04629-2, 33-790, Tyr-674/Tyr-675, PR:000026291|MOD:00160" EXACT PRO-proteoform-std [PRO:DNx] is_a: PR:P04629-2 ! high affinity nerve growth factor receptor isoform TrkA-I (human) relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: lacks_part SO:0000418 ! signal_peptide [Term] id: PR:000049957 name: high affinity nerve growth factor receptor isoform TrkA-I mature form N-glycosylated and phosphorylated 1 (human) def: "A high affinity nerve growth factor receptor isoform TrkA-I (human) that has had the signal peptide removed, is N-glycosylated and has been post-translationally modified to include phosphotyrosine at position 490. UniProtKB:P04629-2, 33-790, Tyr-490, MOD:00048|MOD:00160." [PMID:27655914, PRO:LN] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:27655914). Kinase=("NTRK1"; PR:P04629). synonym: "140-KDa TrkA Tyr(P)-490" RELATED [PMID:27655914] synonym: "hNTRK1/iso:TrkA-I/mature/NGlycoPhos:1" EXACT PRO-short-label [PRO:DAN] synonym: "UniProtKB:P04629-2, 33-790, Tyr-490, MOD:00048|MOD:00160" EXACT PRO-proteoform-std [PRO:DNx] is_a: PR:P04629-2 ! high affinity nerve growth factor receptor isoform TrkA-I (human) relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: lacks_part SO:0000418 ! signal_peptide [Term] id: PR:P04629-4 name: high affinity nerve growth factor receptor isoform TrkA-III (human) def: "A high affinity nerve growth factor receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04629-4." [PRO:DNx, UniProtKB:P04629] comment: Category=organism-sequence. synonym: "hNTRK1/iso:TrkA-III" EXACT PRO-short-label [PRO:DNx] synonym: "high affinity nerve growth factor receptor isoform TrkAIII (human)" EXACT [UniProtKB:P04629] xref: UniProtKB:P04629-4 is_a: PR:P04629 ! high affinity nerve growth factor receptor (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000048644 name: high affinity nerve growth factor receptor, signal peptide removed phosphorylated 1 (human) def: "A high affinity nerve growth factor receptor (human) that has had the signal peptide removed and has been post-translationally modified to include phosphotyrosine at positions 496, 676, 680, 681 and 791 of the amino acid sequence represented by UniProtKB:P04629. UniProtKB:P04629, 33-796, Tyr-496/Tyr-676/Tyr-680/Tyr-681/Tyr-791, MOD:00048." [PRO:DAN, Reactome:R-HSA-3008810, Reactome:R-HSA-3009413] comment: Category=organism-modification. Note: The modified site indicated here (Tyr-496/Tyr-676/Tyr-680/Tyr-681/Tyr-791) are referred to as Tyr-490/Tyr-670/Tyr-674/Tyr-675/Tyr-785 in the literature using the rat sequence. [PRO:DAN, PMID:9099755] synonym: "hNTRK1/SigPep-/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000016724, Tyr-496/Tyr-676/Tyr-680/Tyr-681/Tyr-791, MOD:00048" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:P04629, 33-796, Tyr-496/Tyr-676/Tyr-680/Tyr-681/Tyr-791, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-3008810 "PR:000048644 located_in GO:0000139" xref: Reactome:R-HSA-3009413 "PR:000048644 located_in GO:0005886" is_a: PR:P04629 ! high affinity nerve growth factor receptor (human) relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: lacks_part SO:0000418 ! signal_peptide [Term] id: PR:000048643 name: high affinity nerve growth factor receptor, signal peptide removed form (human) def: "A high affinity nerve growth factor receptor (human) that has had the signal peptide removed. UniProtKB:P04629, 33-796." [PRO:DNx, Reactome:R-HSA-3008784, Reactome:R-HSA-3008805] comment: Category=organism-modification. synonym: "PRO_0000016724" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "hNTRK1/SigPep-" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P04629, 33-796" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-3008784 "PR:000048643 located_in GO:0005886" xref: Reactome:R-HSA-3008805 "PR:000048643 located_in GO:0000139" intersection_of: PR:P04629 ! high affinity nerve growth factor receptor (human) intersection_of: lacks_part SO:0000418 ! signal_peptide relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P04629-1 name: high affinity nerve growth factor receptor isoform TrkA-II (human) def: "A high affinity nerve growth factor receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04629-1." [PRO:DNx, UniProtKB:P04629] comment: Category=organism-sequence. synonym: "hNTRK1/iso:TrkA-II" EXACT PRO-short-label [PRO:DNx] synonym: "high affinity nerve growth factor receptor isoform TrkAII (human)" EXACT [UniProtKB:P04629] xref: UniProtKB:P04629-1 is_a: PR:P04629 ! high affinity nerve growth factor receptor (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P04629-3 name: high affinity nerve growth factor receptor isoform h3 (human) def: "A high affinity nerve growth factor receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04629-3." [PRO:DNx, UniProtKB:P04629] comment: Category=organism-sequence. synonym: "hNTRK1/iso:h3" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P04629-3 is_a: PR:P04629 ! high affinity nerve growth factor receptor (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P04629-2 name: high affinity nerve growth factor receptor isoform TrkA-I (human) def: "A high affinity nerve growth factor receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04629-2." [PRO:DNx, UniProtKB:P04629] comment: Category=organism-sequence. synonym: "hNTRK1/iso:TrkA-I" EXACT PRO-short-label [PRO:DNx] synonym: "high affinity nerve growth factor receptor isoform TrkAI (human)" EXACT [UniProtKB:P04629] xref: UniProtKB:P04629-2 is_a: PR:P04629 ! high affinity nerve growth factor receptor (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000049959 name: high affinity nerve growth factor receptor isoform TrkA-I mature form unphosphorylated and N-glycosylated 1 (human) def: "A high affinity nerve growth factor receptor isoform TrkA-I (human) that has had the signal peptide removed, is N-glycosylated and lacks phosphotyrosine at position 490. UniProtKB:P04629-2, 33-790, Tyr-490, PR:000026291|MOD:00160." [PMID:27655914, PRO:LN] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:27655914). synonym: "hNTRK1/iso:TrkA-I/mature/UnPhosNGlyco:1" EXACT PRO-short-label [PRO:DAN] synonym: "UniProtKB:P04629-2, 33-790, Tyr-490, PR:000026291|MOD:00160" EXACT PRO-proteoform-std [PRO:DNx] is_a: PR:P04629-2 ! high affinity nerve growth factor receptor isoform TrkA-I (human) relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: lacks_part SO:0000418 ! signal_peptide [Term] id: PR:000049958 name: high affinity nerve growth factor receptor isoform TrkA-I mature form N-glycosylated and phosphorylated 2 (human) def: "A high affinity nerve growth factor receptor isoform TrkA-I (human) that has had the signal peptide removed, is N-glycosylated and has been post-translationally modified to include phosphotyrosine at positions Tyr-674 and Tyr-675. UniProtKB:P04629-2, 33-790, Tyr-674/Tyr-675, MOD:00048|MOD:00160." [PMID:27655914, PRO:LN] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:27655914). Kinase=("NTRK1"; PR:P04629; Tyr-674/Tyr-675). synonym: "140-KDa TrkA Tyr(P)-Tyr-674/675" RELATED [PMID:27655914] synonym: "hNTRK1/iso:TrkA-I/mature/NGlycoPhos:2" EXACT PRO-short-label [PRO:DAN] synonym: "UniProtKB:P04629-2, 33-790, Tyr-674/Tyr-675, MOD:00048|MOD:00160" EXACT PRO-proteoform-std [PRO:DNx] is_a: PR:P04629-2 ! high affinity nerve growth factor receptor isoform TrkA-I (human) relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: lacks_part SO:0000418 ! signal_peptide