[Term]
id: PR:P51583
name: bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (rat)
def: "A bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase that is encoded in the genome of rat." [PANTHER:PTHR11609:SF2, PRO:DNx]
comment: Category=organism-gene.
synonym: "Ade2" RELATED Gene-based [UniProtKB:P51583]
synonym: "Airc" RELATED Gene-based [UniProtKB:P51583]
synonym: "Paics" RELATED Gene-based [UniProtKB:P51583]
synonym: "rPAICS" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P51583
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000012235 ! bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase
relationship: has_gene_template RGD:620066 ! Paics (rat)

[Term]
id: PR:Q9I7S8
name: bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (fruit fly)
def: "A bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase that is encoded in the genome of fruit fly." [OMA:Q9I7S8, PANTHER:PTHR11609:SF2, PRO:DNx]
comment: Category=organism-gene.
synonym: "ade5" RELATED Gene-based [UniProtKB:Q9I7S8]
synonym: "Paics" RELATED Gene-based [UniProtKB:Q9I7S8]
synonym: "CG3989" RELATED Gene-based [UniProtKB:Q9I7S8]
synonym: "fly-PAICS" EXACT PRO-short-label [PRO:DNx]
synonym: "PAICS (fruit fly)" EXACT [UniProtKB:Q9I7S8]
synonym: "protein adenosine-5 (fruit fly)" EXACT [UniProtKB:Q9I7S8]
xref: UniProtKB:Q9I7S8
intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster
intersection_of: PR:000012235 ! bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase
relationship: has_gene_template FlyBase:FBgn0020513 ! Paics (fruit fly)

[Term]
id: PR:P22234-2
name: bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform h2 (human)
def: "A bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P22234-2." [PRO:DNx, UniProtKB:P22234]
comment: Category=organism-sequence.
synonym: "hPAICS/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P22234-2
is_a: PR:P22234 ! bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P22234-1
name: bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform 1 (human)
def: "A bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hPAICS/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P22234-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000039065 ! bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform 1

[Term]
id: PR:000039065
name: bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform 1
def: "A bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P22234-1 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "PAICS/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000012235 ! bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

[Term]
id: PR:000020864
name: bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase, initiator methionine removed form
def: "A bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase that has had the initiator methionine removed." [PRO:DNx]
comment: Category=modification.
synonym: "PAICS/InitMet-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000012235 ! bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase
intersection_of: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000012235
name: bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase
def: "A protein that is a translation product of the human PAICS gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "ADE2" RELATED Gene-based []
synonym: "AIRC" RELATED Gene-based []
synonym: "PAIS" RELATED Gene-based []
synonym: "PAICS" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000001 ! protein

[Term]
id: PR:Q9DCL9
name: bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (mouse)
def: "A bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase that is encoded in the genome of mouse." [OMA:Q9DCL9, PRO:DNx]
comment: Category=organism-gene.
synonym: "Paics" RELATED Gene-based [UniProtKB:Q9DCL9]
synonym: "mPAICS" EXACT PRO-short-label [PRO:DNx]
synonym: "PAICS (mouse)" EXACT [UniProtKB:Q9DCL9]
xref: UniProtKB:Q9DCL9
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000012235 ! bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase
relationship: has_gene_template MGI:1914304 ! Paics (mouse)

[Term]
id: PR:P38024
name: multifunctional protein ADE2 (chicken)
def: "A bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase that is encoded in the genome of chicken." [PANTHER:PTHR11609:SF2, PRO:DNx]
comment: Category=organism-gene.
synonym: "AIRC" RELATED Gene-based [UniProtKB:P38024]
synonym: "chick-PAICS" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P38024
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000012235 ! bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase
relationship: has_gene_template NCBIGene:396534 ! AIRC (chicken)

[Term]
id: PR:Q9DCL9-1
name: bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform 1 (mouse)
def: "A bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform 1 that is encoded in the genome of mouse." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "mPAICS/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9DCL9-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000039065 ! bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform 1

[Term]
id: PR:P22234
name: bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (human)
def: "A bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase that is encoded in the genome of human." [PRO:DNx, UniProtKB:P22234]
comment: Category=organism-gene.
synonym: "ADE2" RELATED Gene-based [UniProtKB:P22234]
synonym: "AIRC" RELATED Gene-based [UniProtKB:P22234]
synonym: "PAIS" RELATED Gene-based [UniProtKB:P22234]
synonym: "PAICS" RELATED Gene-based [UniProtKB:P22234]
synonym: "hPAICS" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P22234
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000012235 ! bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase
relationship: has_gene_template HGNC:8587 ! PAICS (human)

[Term]
id: PR:Q10457
name: probable multifunctional protein ADE2 (worm)
def: "A bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase that is encoded in the genome of worm." [PANTHER:PTHR11609:SF2, PRO:DNx]
comment: Category=organism-gene.
synonym: "pacs-1" RELATED Gene-based [UniProtKB:Q10457]
synonym: "B0286.3" RELATED Gene-based [UniProtKB:Q10457]
synonym: "PAICS (worm)" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q10457
intersection_of: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans
intersection_of: PR:000012235 ! bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase
relationship: has_gene_template WormBase:WBGene00015116 ! pacs-1 (worm)

[Term]
id: PR:000048686
name: bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase, initiator methionine removed form (human)
def: "A bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (human) that has had the initiator methionine removed. UniProtKB:P22234, 2-425." [PRO:DNx, Reactome:R-HSA-62502]
comment: Category=organism-modification.
synonym: "PRO_0000075030" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hPAICS/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P22234, 2-425" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-62502 "PR:000048686 located_in GO:0005829"
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:P22234 ! bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P51583-1
name: bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform 1 (rat)
def: "A bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform 1 that is encoded in the genome of rat." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "rPAICS/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P51583-1
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000039065 ! bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform 1