[Term]
id: PR:Q13177-1
name: serine/threonine-protein kinase PAK 2 isoform 1 (human)
def: "A serine/threonine-protein kinase PAK 2 isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hPAK2/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q13177-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000040397 ! serine/threonine-protein kinase PAK 2 isoform 1

[Term]
id: PR:Q13177
name: serine/threonine-protein kinase PAK 2 (human)
def: "A serine/threonine-protein kinase PAK 2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q13177]
comment: Category=organism-gene. Requested by=PubChem.
synonym: "PAK2" RELATED Gene-based [UniProtKB:Q13177]
synonym: "hPAK2" EXACT PRO-short-label [PRO:DNx]
synonym: "p58 (human)" BROAD [UniProtKB:Q13177]
synonym: "PAK-2 (human)" EXACT [UniProtKB:Q13177]
synonym: "PAK65 (human)" EXACT [UniProtKB:Q13177]
synonym: "gamma-PAK (human)" EXACT [UniProtKB:Q13177]
synonym: "S6/H4 kinase (human)" EXACT [UniProtKB:Q13177]
synonym: "p21-activated kinase 2 (human)" EXACT [UniProtKB:Q13177]
xref: Reactome:R-HSA-164946 "PR:Q13177 located_in GO:0005886"
xref: DTO:03100385
xref: UniProtKB:Q13177
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000012241 ! serine/threonine-protein kinase PAK 2
relationship: has_gene_template HGNC:8591 ! PAK2 (human)

[Term]
id: PR:000012241
name: serine/threonine-protein kinase PAK 2
def: "A protein that is a translation product of the human PAK2 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "p58" BROAD [PRO:DNx]
synonym: "PAK2" EXACT PRO-short-label [PRO:DNx]
synonym: "PAK-2" EXACT []
synonym: "PAK65" EXACT []
synonym: "gamma-PAK" EXACT []
synonym: "S6/H4 kinase" EXACT []
synonym: "p21-activated kinase 2" EXACT []
xref: IUPHARobj:2134
is_a: PR:000000001 ! protein

[Term]
id: PR:000048689
name: serine/threonine-protein kinase PAK 2, initiator methionine removed form (human)
def: "A serine/threonine-protein kinase PAK 2 (human) that has had the initiator methionine removed. UniProtKB:Q13177, 2-524." [PRO:DNx, Reactome:R-HSA-211604]
comment: Category=organism-modification.
synonym: "PRO_0000086465" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hPAK2/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q13177, 2-524" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-211604 "PR:000048689 located_in GO:0005829"
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:Q13177 ! serine/threonine-protein kinase PAK 2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000048691
name: serine/threonine-protein kinase PAK 2 phosphorylated 3 (human)
def: "A serine/threonine-protein kinase PAK 2 (human) that has been phosphorylated on the residue at the position equivalent to Ser-141, and phosphothreonine at position 402 of the amino acid sequence represented by UniProtKB:Q13177. UniProtKB:Q13177, Ser-141, MOD:00046|Thr-402, MOD:00047." [PRO:DNx, Reactome:R-HSA-399824, Reactome:R-HSA-5096524]
comment: Category=organism-modification.
synonym: "hPAK2/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q13177, Ser-141, MOD:00046|Thr-402, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-399824 "PR:000048691 located_in GO:0005829"
xref: Reactome:R-HSA-5096524 "PR:000048691 located_in GO:0005886"
is_a: PR:Q13177 ! serine/threonine-protein kinase PAK 2 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000048690
name: serine/threonine-protein kinase PAK 2, initiator methionine removed phosphorylated 2 (human)
def: "A serine/threonine-protein kinase PAK 2 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphoserine at positions 19, 20, 55, 192 and 197 of the amino acid sequence represented by UniProtKB:Q13177. UniProtKB:Q13177, 2-524, Ser-19/Ser-20/Ser-55/Ser-192/Ser-197, MOD:00046." [PRO:DNx, Reactome:R-HSA-211609]
comment: Category=organism-modification.
synonym: "hPAK2/InitMet-/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000086465, Ser-19/Ser-20/Ser-55/Ser-192/Ser-197, MOD:00046" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q13177, 2-524, Ser-19/Ser-20/Ser-55/Ser-192/Ser-197, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-211609 "PR:000048690 located_in GO:0005829"
is_a: PR:Q13177 ! serine/threonine-protein kinase PAK 2 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000048692
name: serine/threonine-protein kinase PAK 2 phosphorylated 4 (human)
def: "A serine/threonine-protein kinase PAK 2 (human) that has been phosphorylated on the residue at the position equivalent to Tyr-130, phosphoserine at position 141, and phosphothreonine at position 402 of the amino acid sequence represented by UniProtKB:Q13177. UniProtKB:Q13177, Tyr-130, MOD:00048|Ser-141, MOD:00046|Thr-402, MOD:00047." [PRO:DNx, Reactome:R-HSA-5218705]
comment: Category=organism-modification.
synonym: "hPAK2/Phos:4" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q13177, Tyr-130, MOD:00048|Ser-141, MOD:00046|Thr-402, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5218705 "PR:000048692 located_in GO:0005829"
is_a: PR:Q13177 ! serine/threonine-protein kinase PAK 2 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000045902
name: serine/threonine-protein kinase PAK 2 phosphorylated 1 (human)
def: "A serine/threonine-protein kinase PAK 2 (human) that has been phosphorylated at Tyr-130. UniProtKB:Q13177, Tyr-130, MOD:00048." [PMID:12215529, iPTMnet:Q13177]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:12215529). Status=unreviewed.
synonym: "hPAK2/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q13177, Tyr-130, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:Q13177 ! serine/threonine-protein kinase PAK 2 (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens