[Term]
id: PR:Q8NBP7-1
name: proprotein convertase subtilisin/kexin type 9 isoform h1 (human)
def: "A proprotein convertase subtilisin/kexin type 9 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8NBP7-1." [PRO:DNx, UniProtKB:Q8NBP7]
comment: Category=organism-sequence.
synonym: "hPCSK9/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8NBP7-1
is_a: PR:Q8NBP7 ! proprotein convertase subtilisin/kexin type 9 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000012440
name: proprotein convertase subtilisin/kexin type 9
def: "A protein that is a translation product of the human PCSK9 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "PC9" EXACT []
synonym: "NARC1" RELATED Gene-based []
synonym: "PCSK9" EXACT PRO-short-label [PRO:DNx]
synonym: "NARC-1" EXACT []
synonym: "PSEC0052" RELATED Gene-based []
synonym: "proprotein convertase 9" EXACT []
synonym: "subtilisin/kexin-like protease PC9" EXACT []
synonym: "neural apoptosis-regulated convertase 1" EXACT []
xref: IUPHARobj:2388
is_a: PR:000000001 ! protein

[Term]
id: PR:000050078
name: proprotein convertase subtilisin/kexin type 9 propeptide (human)
def: "A proprotein convertase subtilisin/kexin type 9 (human) that has had the signal peptide removed and that corresponds to the N-terminal portion after auto-proteolysis. Example: UniProtKB:Q8NBP7-1, 31-152." [PRO:DAN, UniProtKB:Q8NBP7]
comment: Category=organism-modification.
synonym: "PRO_0000027120" NARROW PRO-proteoform-ftid [PRO:DNx]
synonym: "hPCSK9/propeptide" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q8NBP7-1, 31-152" NARROW PRO-proteoform-std [PRO:DNx]
intersection_of: PR:Q8NBP7 ! proprotein convertase subtilisin/kexin type 9 (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
intersection_of: has_part SO:0001062 ! propeptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000050079
name: proprotein convertase subtilisin/kexin type 9, mature form (human)
def: "A proprotein convertase subtilisin/kexin type 9 (human) that has had the signal peptide and propeptide removed. Example: UniProtKB:Q8NBP7-1, 153-692." [PRO:DNx, UniProtKB:Q8NBP7]
comment: Category=organism-modification.
synonym: "hPCSK9/mature" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000027121" NARROW PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q8NBP7-1, 153-692" NARROW PRO-proteoform-std [PRO:DNx]
intersection_of: PR:Q8NBP7 ! proprotein convertase subtilisin/kexin type 9 (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
intersection_of: lacks_part SO:0001062 ! propeptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q8NBP7-2
name: proprotein convertase subtilisin/kexin type 9 isoform h2 (human)
def: "A proprotein convertase subtilisin/kexin type 9 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8NBP7-2." [PRO:DNx, UniProtKB:Q8NBP7]
comment: Category=organism-sequence.
synonym: "hPCSK9/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8NBP7-2
is_a: PR:Q8NBP7 ! proprotein convertase subtilisin/kexin type 9 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q8NBP7
name: proprotein convertase subtilisin/kexin type 9 (human)
def: "A proprotein convertase subtilisin/kexin type 9 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q8NBP7]
comment: Category=organism-gene.
synonym: "NARC1" RELATED Gene-based [UniProtKB:Q8NBP7]
synonym: "PCSK9" RELATED Gene-based [UniProtKB:Q8NBP7]
synonym: "hPCSK9" EXACT PRO-short-label [PRO:DNx]
synonym: "PSEC0052" RELATED Gene-based [UniProtKB:Q8NBP7]
synonym: "PC9 (human)" EXACT [UniProtKB:Q8NBP7]
synonym: "NARC-1 (human)" EXACT [UniProtKB:Q8NBP7]
synonym: "proprotein convertase 9 (human)" EXACT [UniProtKB:Q8NBP7]
synonym: "subtilisin/kexin-like protease PC9 (human)" EXACT [UniProtKB:Q8NBP7]
synonym: "neural apoptosis-regulated convertase 1 (human)" EXACT [UniProtKB:Q8NBP7]
xref: UniProtKB:Q8NBP7
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000012440 ! proprotein convertase subtilisin/kexin type 9
relationship: has_gene_template HGNC:20001 ! PCSK9 (human)