[Term]
id: PR:000048770
name: phosphatidylinositol 3-kinase regulatory subunit alpha ubiquitinated form (human)
def: "A phosphatidylinositol 3-kinase regulatory subunit alpha (human) that includes at least one ubiquitinated lysine. UniProtKB:P27986, MOD:01148." [PRO:DNx, Reactome:R-HSA-3080572]
comment: Category=organism-modification.
synonym: "hPIK3R1/UbiqLys+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P27986, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-3080572 "PR:000048770 located_in GO:0005829"
intersection_of: has_part MOD:01148 ! ubiquitinylated lysine
intersection_of: PR:P27986 ! phosphatidylinositol 3-kinase regulatory subunit alpha (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P27986-4
name: phosphatidylinositol 3-kinase regulatory subunit alpha isoform h4 (human)
def: "A phosphatidylinositol 3-kinase regulatory subunit alpha (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P27986-4." [PRO:DNx, UniProtKB:P27986]
comment: Category=organism-sequence.
synonym: "hPIK3R1/iso:h4" EXACT PRO-short-label [PRO:DNx]
synonym: "phosphatidylinositol 3-kinase regulatory subunit alpha isoform p85I (human)" EXACT [UniProtKB:P27986]
xref: UniProtKB:P27986-4
is_a: PR:P27986 ! phosphatidylinositol 3-kinase regulatory subunit alpha (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P27986-5
name: phosphatidylinositol 3-kinase regulatory subunit alpha isoform h5 (human)
def: "A phosphatidylinositol 3-kinase regulatory subunit alpha (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P27986-5." [PRO:DNx, UniProtKB:P27986]
comment: Category=organism-sequence.
synonym: "hPIK3R1/iso:h5" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P27986-5
is_a: PR:P27986 ! phosphatidylinositol 3-kinase regulatory subunit alpha (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P27986-1
name: phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1 (human)
def: "A phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hPIK3R1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P27986-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000039182 ! phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1

[Term]
id: PR:P27986-2
name: phosphatidylinositol 3-kinase regulatory subunit alpha isoform h2 (human)
def: "A phosphatidylinositol 3-kinase regulatory subunit alpha (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P27986-2." [PRO:DNx, UniProtKB:P27986]
comment: Category=organism-sequence.
synonym: "hPIK3R1/iso:h2" EXACT PRO-short-label [PRO:DNx]
synonym: "phosphatidylinositol 3-kinase regulatory subunit alpha isoform AS53 (human)" EXACT [UniProtKB:P27986]
xref: UniProtKB:P27986-2
is_a: PR:P27986 ! phosphatidylinositol 3-kinase regulatory subunit alpha (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P27986-3
name: phosphatidylinositol 3-kinase regulatory subunit alpha isoform h3 (human)
def: "A phosphatidylinositol 3-kinase regulatory subunit alpha (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P27986-3." [PRO:DNx, UniProtKB:P27986]
comment: Category=organism-sequence.
synonym: "hPIK3R1/iso:h3" EXACT PRO-short-label [PRO:DNx]
synonym: "phosphatidylinositol 3-kinase regulatory subunit alpha isoform p46 (human)" EXACT [UniProtKB:P27986]
xref: UniProtKB:P27986-3
is_a: PR:P27986 ! phosphatidylinositol 3-kinase regulatory subunit alpha (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000012724
name: phosphatidylinositol 3-kinase regulatory subunit alpha
def: "A protein that is a translation product of the human PIK3R1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "GRB1" RELATED Gene-based []
synonym: "PIK3R1" EXACT PRO-short-label [PRO:DNx]
synonym: "PI3-kinase subunit p85-alpha" EXACT []
synonym: "PI3K regulatory subunit alpha" EXACT []
synonym: "PI3-kinase regulatory subunit alpha" EXACT []
synonym: "PtdIns-3-kinase regulatory subunit alpha" EXACT []
synonym: "PtdIns-3-kinase regulatory subunit p85-alpha" EXACT []
synonym: "phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha" EXACT []
xref: IUPHARobj:2503
is_a: PR:000000001 ! protein

[Term]
id: PR:P27986
name: phosphatidylinositol 3-kinase regulatory subunit alpha (human)
def: "A phosphatidylinositol 3-kinase regulatory subunit alpha that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-gene.
synonym: "GRB1" RELATED Gene-based [UniProtKB:P27986]
synonym: "PIK3R1" RELATED Gene-based [UniProtKB:P27986]
synonym: "hPIK3R1" EXACT PRO-short-label [PRO:DNx]
synonym: "PI3-kinase subunit p85-alpha (human)" EXACT [UniProtKB:P27986]
synonym: "PI3K regulatory subunit alpha (human)" EXACT [UniProtKB:P27986]
synonym: "PI3-kinase regulatory subunit alpha (human)" EXACT [UniProtKB:P27986]
synonym: "PtdIns-3-kinase regulatory subunit alpha (human)" EXACT [UniProtKB:P27986]
synonym: "PtdIns-3-kinase regulatory subunit p85-alpha (human)" EXACT [UniProtKB:P27986]
synonym: "phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha (human)" EXACT [UniProtKB:P27986]
xref: Reactome:R-HSA-74789 "PR:P27986 located_in GO:0005829"
xref: Reactome:R-HSA-198365 "PR:P27986 located_in GO:0005886"
xref: DTO:03100382
xref: UniProtKB:P27986
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000012724 ! phosphatidylinositol 3-kinase regulatory subunit alpha
relationship: has_gene_template HGNC:8979 ! PIK3R1 (human)

[Term]
id: PR:000045733
name: phosphatidylinositol 3-kinase regulatory subunit alpha phosphorylated 1 (human)
def: "A phosphatidylinositol 3-kinase regulatory subunit alpha (human) that has been phosphorylated on the residue at the position equivalent to Tyr-688 of the amino acid sequence represented by UniProtKB:P27986-1. Example: UniProtKB:P27986-1, Tyr-688, MOD:00048." [PMID:11337495, iPTMnet:P27986]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:11337495). Status=unreviewed.
synonym: "hPIK3R1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P27986-1, Tyr-688, MOD:00048" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P27986 ! phosphatidylinositol 3-kinase regulatory subunit alpha (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens