[Term]
id: PR:000012837
name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
def: "A phospholipase C-gamma that is a translation product of the human PLCG2 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "PLCG2" EXACT PRO-short-label [PRO:DNx]
synonym: "PLC-IV" EXACT []
synonym: "PLC-gamma-2" EXACT []
synonym: "phospholipase C-IV" EXACT []
synonym: "phospholipase C-gamma-2" EXACT []
synonym: "phosphoinositide phospholipase C-gamma-2" EXACT []
xref: IUPHARobj:1408
is_a: PR:000050049 ! phospholipase C-gamma

[Term]
id: PR:P16885
name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (human)
def: "A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P16885]
comment: Category=organism-gene.
synonym: "PLCG2" RELATED Gene-based [UniProtKB:P16885]
synonym: "hPLCG2" EXACT PRO-short-label [PRO:DNx]
synonym: "PLC-IV (human)" EXACT [UniProtKB:P16885]
synonym: "PLC-gamma-2 (human)" EXACT [UniProtKB:P16885]
synonym: "phospholipase C-IV (human)" EXACT [UniProtKB:P16885]
synonym: "phospholipase C-gamma-2 (human)" EXACT [UniProtKB:P16885]
synonym: "phosphoinositide phospholipase C-gamma-2 (human)" EXACT [UniProtKB:P16885]
xref: Reactome:R-HSA-114601 "PR:P16885 located_in GO:0005886"
xref: Reactome:R-HSA-984806 "PR:P16885 located_in GO:0005829"
xref: Reactome:R-HSA-2023875 "PR:P16885 located_in GO:0005886"
xref: Reactome:R-HSA-1604645 "PR:P16885 located_in GO:0005829"
xref: UniProtKB:P16885
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000012837 ! 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
relationship: has_gene_template HGNC:9066 ! PLCG2 (human)

[Term]
id: PR:P16885-1
name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform 1 (human)
def: "A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hPLCG2/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P16885-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000038964 ! 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform 1

[Term]
id: PR:000048808
name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 phosphorylated 3 (human)
def: "A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (human) that has been post-translationally modified to include phosphotyrosine at positions 753, 759 and 1217 of the amino acid sequence represented by UniProtKB:P16885. UniProtKB:P16885, Tyr-753/Tyr-759/Tyr-1217, MOD:00048." [PRO:DNx, Reactome:R-HSA-984816]
comment: Category=organism-modification.
synonym: "hPLCG2/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P16885, Tyr-753/Tyr-759/Tyr-1217, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-984816 "PR:000048808 located_in GO:0005886"
is_a: PR:P16885 ! 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000048809
name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 phosphorylated form (human)
def: "A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (human) that includes at least one phosphorylated residue. UniProtKB:P16885, MOD:00696." [PRO:DNx, Reactome:R-HSA-114602]
comment: Category=organism-modification.
synonym: "hPLCG2/PhosRes+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P16885, MOD:00696" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-114602 "PR:000048809 located_in GO:0005886"
intersection_of: has_part MOD:00696 ! phosphorylated residue
intersection_of: PR:P16885 ! 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000048806
name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 phosphorylated 1 (human)
def: "A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (human) that has been post-translationally modified to include phosphotyrosine at positions 753 and 759 of the amino acid sequence represented by UniProtKB:P16885. UniProtKB:P16885, Tyr-753/Tyr-759, MOD:00048." [PRO:DNx, Reactome:R-HSA-5607631, Reactome:R-HSA-5607640]
comment: Category=organism-modification.
synonym: "hPLCG2/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P16885, Tyr-753/Tyr-759, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5607631 "PR:000048806 located_in GO:0005829"
xref: Reactome:R-HSA-5607640 "PR:000048806 located_in GO:0005886"
is_a: PR:P16885 ! 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000048807
name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 phosphorylated 2 (human)
def: "A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (human) that has been post-translationally modified to include phosphotyrosine at positions 753, 759, 1197 and 1217 of the amino acid sequence represented by UniProtKB:P16885. UniProtKB:P16885, Tyr-753/Tyr-759/Tyr-1197/Tyr-1217, MOD:00048." [PRO:DNx, Reactome:R-HSA-2685601]
comment: Category=organism-modification.
synonym: "hPLCG2/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P16885, Tyr-753/Tyr-759/Tyr-1197/Tyr-1217, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-2685601 "PR:000048807 located_in GO:0005886"
is_a: PR:P16885 ! 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens