[Term]
id: PR:000025900
name: cAMP-dependent protein kinase catalytic subunit alpha isoform 1, initiator methionine removed phosphorylated 2 (mouse)
def: "A cAMP-dependent protein kinase catalytic subunit alpha isoform 1, initiator methionine removed phosphorylated 2 in mouse. UniProtKB:P05132-1, 2-351, Thr-198, MOD:00047|Ser-339, MOD:00046." [OCA:JP, PMID:14705934, PMID:14757059]
comment: Category=organism-modification.
synonym: "mPRKACA/iso:1/InitMet-/Phos:2" EXACT PRO-short-label [PRO:DAN]
synonym: "PRO_0000086053, Thr-198, MOD:00047|Ser-339, MOD:00046" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P05132-1, 2-351, Thr-198, MOD:00047|Ser-339, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: PDB:1RDQ
xref: PDB:1RE8
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000025899 ! cAMP-dependent protein kinase catalytic subunit alpha isoform 1, initiator methionine removed phosphorylated 2
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000021087
name: cAMP-dependent protein kinase catalytic subunit alpha, initiator methionine removed form
def: "A cAMP-dependent protein kinase catalytic subunit alpha that has had the initiator methionine removed." [PRO:DNx]
comment: Category=modification.
synonym: "PRKACA/InitMet-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000013222 ! cAMP-dependent protein kinase catalytic subunit alpha
intersection_of: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000025885
name: cAMP-dependent protein kinase catalytic subunit alpha isoform 1
def: "A cAMP-dependent protein kinase catalytic subunit alpha that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P17612-1 or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=sequence.
synonym: "PRKACA/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000013222 ! cAMP-dependent protein kinase catalytic subunit alpha

[Term]
id: PR:P17612-1
name: cAMP-dependent protein kinase catalytic subunit alpha isoform 1 (human)
def: "A cAMP-dependent protein kinase catalytic subunit alpha isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence. Requested by=PubChem.
synonym: "hPRKACA/iso:1" EXACT PRO-short-label [PRO:DNx]
synonym: "cAMP-dependent protein kinase catalytic subunit alpha isoform C-alpha-1 (human)" EXACT [UniProtKB:P17612]
xref: UniProtKB:P17612-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000025885 ! cAMP-dependent protein kinase catalytic subunit alpha isoform 1

[Term]
id: PR:000025887
name: cAMP-dependent protein kinase catalytic subunit alpha isoform 1, initiator methionine removed phosphorylated 1 (cow)
def: "A cAMP-dependent protein kinase catalytic subunit alpha isoform 1, initiator methionine removed phosphorylated 1 in cow. UniProtKB:P00517-1, 2-351, Ser-11/Ser-339, MOD:00046|Thr-198, MOD:00047." [OCA:JP, PMID:14656443]
comment: Category=organism-modification.
synonym: "cow-PRKACA/iso:1/InitMet-/Phos:1" EXACT PRO-short-label [PRO:DAN]
synonym: "PRO_0000086049, Ser-11/Ser-339, MOD:00046|Thr-198, MOD:00047" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P00517-1, 2-351, Ser-11/Ser-339, MOD:00046|Thr-198, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: PDB:1Q8T
xref: PDB:1Q8U
intersection_of: only_in_taxon NCBITaxon:9913 ! Bos taurus
intersection_of: PR:000025886 ! cAMP-dependent protein kinase catalytic subunit alpha isoform 1, initiator methionine removed phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000025886
name: cAMP-dependent protein kinase catalytic subunit alpha isoform 1, initiator methionine removed phosphorylated 1
def: "A cAMP-dependent protein kinase catalytic subunit alpha isoform 1 that has had the initiator methionine removed and has been post-translationally modified to include phosphorylation at positions equivalent to Ser-11, Thr-198 and Ser-339 of the amino acid sequence represented by UniProtKB:P05132-1. Example: UniProtKB:P05132-1, 2-351, Ser-11/Ser-339, MOD:00046|Thr-198, MOD:00047." [PRO:CNA, PRO:DAN]
comment: Category=modification.
synonym: "PRKACA/iso:1/InitMet-/Phos:1" EXACT PRO-short-label [PRO:DAN]
is_a: PR:000025885 ! cAMP-dependent protein kinase catalytic subunit alpha isoform 1
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000026563
name: cAMP-dependent protein kinase catalytic subunit alpha isoform 1, initiator methionine removed form
def: "A cAMP-dependent protein kinase catalytic subunit alpha isoform 1 that has had the initiator methionine removed." [PRO:DNx]
comment: Category=modification.
synonym: "PRKACA/iso:1/InitMet-" EXACT PRO-short-label [PRO:DNx]
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:000025885 ! cAMP-dependent protein kinase catalytic subunit alpha isoform 1

[Term]
id: PR:P17612
name: cAMP-dependent protein kinase catalytic subunit alpha (human)
def: "A cAMP-dependent protein kinase catalytic subunit alpha that is encoded in the genome of human." [PRO:DNx, UniProtKB:P17612]
comment: Category=organism-gene.
synonym: "PKACA" RELATED Gene-based [UniProtKB:P17612]
synonym: "PRKACA" RELATED Gene-based [UniProtKB:P17612]
synonym: "hPRKACA" EXACT PRO-short-label [PRO:DNx]
synonym: "PKA C-alpha (human)" EXACT [UniProtKB:P17612]
xref: DTO:03100204
xref: UniProtKB:P17612
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000013222 ! cAMP-dependent protein kinase catalytic subunit alpha
relationship: has_gene_template HGNC:9380 ! PRKACA (human)

[Term]
id: PR:000025898
name: cAMP-dependent protein kinase catalytic subunit alpha isoform 1, initiator methionine removed phosphorylated 1 (mouse)
def: "A cAMP-dependent protein kinase catalytic subunit alpha isoform 1, initiator methionine removed phosphorylated 1 in mouse. UniProtKB:P05132-1, 2-351, Ser-11/Ser-339, MOD:00046|Thr-198, MOD:00047." [OCA:JP, PMID:9261084]
comment: Category=organism-modification.
synonym: "mPRKACA/iso:1/InitMet-/Phos:1" EXACT PRO-short-label [PRO:DAN]
synonym: "PRO_0000086053, Ser-11/Ser-339, MOD:00046|Thr-198, MOD:00047" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P05132-1, 2-351, Ser-11/Ser-339, MOD:00046|Thr-198, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: PDB:1BKX
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000025886 ! cAMP-dependent protein kinase catalytic subunit alpha isoform 1, initiator methionine removed phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000025899
name: cAMP-dependent protein kinase catalytic subunit alpha isoform 1, initiator methionine removed phosphorylated 2
def: "A cAMP-dependent protein kinase catalytic subunit alpha isoform 1 that has had the initiator methionine removed and has been phosphorylated in Ser and Thr residues, but not including those at the N-terminal region. Example: UniProtKB:P05132-1, 2-351, Thr-198, MOD:00047|Ser-339, MOD:00046." [PRO:CNA, PRO:DAN]
comment: Category=modification.
synonym: "PRKACA/iso:1/InitMet-/Phos:2" EXACT PRO-short-label [PRO:DAN]
is_a: PR:000025885 ! cAMP-dependent protein kinase catalytic subunit alpha isoform 1
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:P00517
name: cAMP-dependent protein kinase catalytic subunit alpha (cow)
def: "A cAMP-dependent protein kinase catalytic subunit alpha that is encoded in the genome of cow." [OMA:P00517, PRO:DNx]
comment: Category=organism-gene.
synonym: "PRKACA" RELATED Gene-based [UniProtKB:P00517]
synonym: "cow-PRKACA" EXACT PRO-short-label [PRO:DNx]
synonym: "PKA C-alpha (cow)" EXACT [UniProtKB:P00517]
xref: UniProtKB:P00517
intersection_of: only_in_taxon NCBITaxon:9913 ! Bos taurus
intersection_of: PR:000013222 ! cAMP-dependent protein kinase catalytic subunit alpha
relationship: has_gene_template NCBIGene:282322 ! PRKACA (cow)

[Term]
id: PR:000048904
name: cAMP-dependent protein kinase catalytic subunit alpha, initiator methionine removed form (human)
def: "A cAMP-dependent protein kinase catalytic subunit alpha (human) that has had the initiator methionine removed. UniProtKB:P17612, 2-351." [PRO:DNx, Reactome:R-HSA-111936, Reactome:R-HSA-5610402, Reactome:R-HSA-57844]
comment: Category=organism-modification.
synonym: "PRO_0000086052" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hPRKACA/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P17612, 2-351" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-111936 "PR:000048904 located_in GO:0005654"
xref: Reactome:R-HSA-57844 "PR:000048904 located_in GO:0005829"
xref: Reactome:R-HSA-5610402 "PR:000048904 located_in GO:0097546"
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:P17612 ! cAMP-dependent protein kinase catalytic subunit alpha (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P05132
name: cAMP-dependent protein kinase catalytic subunit alpha (mouse)
def: "A cAMP-dependent protein kinase catalytic subunit alpha that is encoded in the genome of mouse." [OMA:P05132, PRO:DNx]
comment: Category=organism-gene.
synonym: "Pkaca" RELATED Gene-based [UniProtKB:P05132]
synonym: "Prkaca" RELATED Gene-based [UniProtKB:P05132]
synonym: "mPRKACA" EXACT PRO-short-label [PRO:DNx]
synonym: "PKA C-alpha (mouse)" EXACT [UniProtKB:P05132]
xref: UniProtKB:P05132
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000013222 ! cAMP-dependent protein kinase catalytic subunit alpha
relationship: has_gene_template MGI:97592 ! Prkaca (mouse)

[Term]
id: PR:P00517-1
name: cAMP-dependent protein kinase catalytic subunit alpha isoform 1 (cow)
def: "A cAMP-dependent protein kinase catalytic subunit alpha isoform 1 that is encoded in the genome of cow." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "cow-PRKACA/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P00517-1
intersection_of: only_in_taxon NCBITaxon:9913 ! Bos taurus
intersection_of: PR:000025885 ! cAMP-dependent protein kinase catalytic subunit alpha isoform 1

[Term]
id: PR:P05132-2
name: cAMP-dependent protein kinase catalytic subunit alpha isoform 2 (mouse)
def: "A cAMP-dependent protein kinase catalytic subunit alpha isoform 2 that is encoded in the genome of mouse." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "mPRKACA/iso:2" EXACT PRO-short-label [PRO:DNx]
synonym: "cAMP-dependent protein kinase catalytic subunit alpha isoform C(s) (mouse)" EXACT [UniProtKB:P05132]
synonym: "cAMP-dependent protein kinase catalytic subunit alpha isoform C-alpha-2 (mouse)" EXACT [UniProtKB:P05132]
synonym: "cAMP-dependent protein kinase catalytic subunit alpha isoform C-alpha-S (mouse)" EXACT [UniProtKB:P05132]
xref: UniProtKB:P05132-2
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000038982 ! cAMP-dependent protein kinase catalytic subunit alpha isoform 2

[Term]
id: PR:000038982
name: cAMP-dependent protein kinase catalytic subunit alpha isoform 2
def: "A cAMP-dependent protein kinase catalytic subunit alpha that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P17612-2 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "PRKACA/iso:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000013222 ! cAMP-dependent protein kinase catalytic subunit alpha

[Term]
id: PR:P05132-1
name: cAMP-dependent protein kinase catalytic subunit alpha isoform 1 (mouse)
def: "A cAMP-dependent protein kinase catalytic subunit alpha isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mPRKACA/iso:1" EXACT PRO-short-label [PRO:DNx]
synonym: "cAMP-dependent protein kinase catalytic subunit alpha isoform C-alpha-1 (mouse)" EXACT [UniProtKB:P05132]
xref: UniProtKB:P05132-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000025885 ! cAMP-dependent protein kinase catalytic subunit alpha isoform 1

[Term]
id: PR:P17612-2
name: cAMP-dependent protein kinase catalytic subunit alpha isoform 2 (human)
def: "A cAMP-dependent protein kinase catalytic subunit alpha isoform 2 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hPRKACA/iso:2" EXACT PRO-short-label [PRO:DNx]
synonym: "cAMP-dependent protein kinase catalytic subunit alpha isoform C(s) (human)" EXACT [UniProtKB:P17612]
synonym: "cAMP-dependent protein kinase catalytic subunit alpha isoform C-alpha-2 (human)" EXACT [UniProtKB:P17612]
synonym: "cAMP-dependent protein kinase catalytic subunit alpha isoform C-alpha-S (human)" EXACT [UniProtKB:P17612]
xref: UniProtKB:P17612-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000038982 ! cAMP-dependent protein kinase catalytic subunit alpha isoform 2

[Term]
id: PR:000013222
name: cAMP-dependent protein kinase catalytic subunit alpha
def: "A cAMP-dependent protein kinase catalytic subunit that is a translation product of the human PRKACA gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "PKACA" RELATED Gene-based []
synonym: "PRKACA" EXACT PRO-short-label [PRO:DNx]
synonym: "PKA C-alpha" EXACT []
xref: IUPHARobj:1476
is_a: PR:000029188 ! cAMP-dependent protein kinase catalytic subunit