[Term]
id: PR:000013875
name: transcription factor p65
def: "A protein that is a translation product of the human RELA gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "RELA" EXACT PRO-short-label [PRO:DNx]
synonym: "NFKB3" RELATED Gene-based []
synonym: "nuclear factor NF-kappa-B p65 subunit" EXACT []
synonym: "nuclear factor of kappa light polypeptide gene enhancer in B-cells 3" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:Q04206-2
name: transcription factor p65 isoform h2 (human)
def: "A transcription factor p65 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q04206-2." [PRO:DNx, UniProtKB:Q04206]
comment: Category=organism-sequence.
synonym: "hRELA/iso:h2" EXACT PRO-short-label [PRO:DNx]
synonym: "transcription factor p65 isoform p65 delta 2 (human)" EXACT [UniProtKB:Q04206]
xref: UniProtKB:Q04206-2
is_a: PR:Q04206 ! transcription factor p65 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q04206-1
name: transcription factor p65 isoform 1 (human)
def: "A transcription factor p65 isoform 1 that is encoded in the genome of human." [KAT:Q04206]
comment: Category=organism-sequence.
synonym: "hRELA/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q04206-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027915 ! transcription factor p65 isoform 1

[Term]
id: PR:Q04206-4
name: transcription factor p65 isoform h4 (human)
def: "A transcription factor p65 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q04206-4." [PRO:DNx, UniProtKB:Q04206]
comment: Category=organism-sequence.
synonym: "hRELA/iso:h4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q04206-4
is_a: PR:Q04206 ! transcription factor p65 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000027920
name: transcription factor p65 isoform 1 acetylated 2 (human)
def: "A transcription factor p65 isoform 1 acetylated 2 in human. UniProtKB:Q04206-1, Lys-122/Lys-123, MOD:00064." [KAT:Q04206, PMID:12419806]
comment: Category=organism-modification. Acetylase=("EP300"; PR:Q09472). Acetylase=("KAT2B"; PR:Q92831).
synonym: "hRELA/iso:1/Ac:2" EXACT PRO-short-label [PRO:DNx]
synonym: "p65-AcLys122-AcLys123" RELATED []
synonym: "UniProtKB:Q04206-1, Lys-122/Lys-123, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027919 ! transcription factor p65 isoform 1 acetylated 2
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine

[Term]
id: PR:000027918
name: transcription factor p65 isoform 1 acetylated 1 (human)
def: "A transcription factor p65 isoform 1 acetylated 1 in human. UniProtKB:Q04206-1, Lys-310/Lys-314/Lys-315, MOD:00064." [KAT:Q04206, PMID:20064247]
comment: Category=organism-modification. Acetylase=("EP300"; PR:Q09472).
synonym: "hRELA/iso:1/Ac:1" EXACT PRO-short-label [PRO:DNx]
synonym: "p65-AcLys310-AcLys314-AcLys315" RELATED []
synonym: "UniProtKB:Q04206-1, Lys-310/Lys-314/Lys-315, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027917 ! transcription factor p65 isoform 1 acetylated 1
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine

[Term]
id: PR:000049038
name: transcription factor p65 phosphorylated 2 (human)
def: "A transcription factor p65 (human) that has been phosphorylated on the residue at the position equivalent to Ser-276 of the amino acid sequence represented by UniProtKB:Q04206. UniProtKB:Q04206, Ser-276, MOD:00046." [PRO:DNx, Reactome:R-HSA-5624468]
comment: Category=organism-modification.
synonym: "hRELA/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q04206, Ser-276, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5624468 "PR:000049038 located_in GO:0005654"
is_a: PR:Q04206 ! transcription factor p65 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q04206-3
name: transcription factor p65 isoform h3 (human)
def: "A transcription factor p65 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q04206-3." [PRO:DNx, UniProtKB:Q04206]
comment: Category=organism-sequence.
synonym: "hRELA/iso:h3" EXACT PRO-short-label [PRO:DNx]
synonym: "transcription factor p65 isoform p65 delta (human)" EXACT [UniProtKB:Q04206]
xref: UniProtKB:Q04206-3
is_a: PR:Q04206 ! transcription factor p65 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q04206
name: transcription factor p65 (human)
def: "A transcription factor p65 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-gene.
synonym: "RELA" RELATED Gene-based [UniProtKB:Q04206]
synonym: "NFKB3" RELATED Gene-based [UniProtKB:Q04206]
synonym: "hRELA" EXACT PRO-short-label [PRO:DNx]
synonym: "nuclear factor NF-kappa-B p65 subunit (human)" EXACT [UniProtKB:Q04206]
synonym: "nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 (human)" EXACT [UniProtKB:Q04206]
xref: Reactome:R-HSA-168172 "PR:Q04206 located_in GO:0005829"
xref: Reactome:R-HSA-177676 "PR:Q04206 located_in GO:0005654"
xref: UniProtKB:Q04206
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000013875 ! transcription factor p65
relationship: has_gene_template HGNC:9955 ! RELA (human)

[Term]
id: PR:000045875
name: transcription factor p65 phosphorylated 1 (human)
def: "A transcription factor p65 (human) that has been phosphorylated on the residue at the position equivalent to Ser-536 of the amino acid sequence represented by UniProtKB:Q04206-1. Example: UniProtKB:Q04206-1, Ser-536, MOD:00046." [PMID:15128824, PMID:15485852, PMID:15489227, PMID:16840782, PMID:17785205, iPTMnet:Q04206]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:15128824, PMID:15485852, PMID:15489227, PMID:16840782, PMID:17785205). Status=unreviewed.
synonym: "hRELA/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q04206-1, Ser-536, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:Q04206 ! transcription factor p65 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens