[Term]
id: PR:P58801
name: receptor-interacting serine/threonine-protein kinase 2 (mouse)
def: "A receptor-interacting serine/threonine-protein kinase 2 that is encoded in the genome of mouse." [OMA:P58801, PRO:DNx]
comment: Category=organism-gene.
synonym: "Ripk2" RELATED Gene-based [UniProtKB:P58801]
synonym: "mRIPK2" EXACT PRO-short-label [PRO:DNx]
synonym: "tyrosine-protein kinase RIPK2 (mouse)" EXACT [UniProtKB:P58801]
xref: UniProtKB:P58801
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000014023 ! receptor-interacting serine/threonine-protein kinase 2
relationship: has_gene_template MGI:1891456 ! Ripk2 (mouse)

[Term]
id: PR:O43353-2
name: receptor-interacting serine/threonine-protein kinase 2 isoform h2 (human)
def: "A receptor-interacting serine/threonine-protein kinase 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43353-2." [PRO:DNx, UniProtKB:O43353]
comment: Category=organism-sequence.
synonym: "hRIPK2/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O43353-2
is_a: PR:O43353 ! receptor-interacting serine/threonine-protein kinase 2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O43353-1
name: receptor-interacting serine/threonine-protein kinase 2 isoform h1 (human)
def: "A receptor-interacting serine/threonine-protein kinase 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43353-1." [PRO:DNx, UniProtKB:O43353]
comment: Category=organism-sequence.
synonym: "hRIPK2/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O43353-1
is_a: PR:O43353 ! receptor-interacting serine/threonine-protein kinase 2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000045585
name: receptor-interacting serine/threonine-protein kinase 2 phosphorylated 1 (human)
def: "A receptor-interacting serine/threonine-protein kinase 2 (human) that has been phosphorylated on the residue at the position equivalent to Tyr-474 of the amino acid sequence represented by UniProtKB:O43353-1. Example: UniProtKB:O43353-1, Tyr-474, MOD:00048." [PMID:21123652, iPTMnet:O43353]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:21123652). Status=unreviewed.
synonym: "hRIPK2/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O43353-1, Tyr-474, MOD:00048" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:O43353 ! receptor-interacting serine/threonine-protein kinase 2 (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000014023
name: receptor-interacting serine/threonine-protein kinase 2
def: "A protein that is a translation product of the human RIPK2 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "RICK" RELATED Gene-based []
synonym: "RIP2" RELATED Gene-based []
synonym: "RIP-2" EXACT []
synonym: "RIPK2" EXACT PRO-short-label [PRO:DNx]
synonym: "CARDIAK" RELATED Gene-based []
synonym: "UNQ277/PRO314/PRO34092" RELATED Gene-based []
synonym: "tyrosine-protein kinase RIPK2" EXACT []
synonym: "receptor-interacting protein 2" EXACT []
synonym: "RIP-like-interacting CLARP kinase" EXACT []
synonym: "CARD-containing IL-1 beta ICE-kinase" EXACT []
synonym: "CARD-containing interleukin-1 beta-converting enzyme-associated kinase" EXACT []
xref: IUPHARobj:2190
is_a: PR:000000001 ! protein

[Term]
id: PR:000049046
name: receptor-interacting serine/threonine-protein kinase 2 ubiquitinated 1 (human)
def: "A receptor-interacting serine/threonine-protein kinase 2 (human) that has been ubiquitinated on the residue at the position equivalent to Lys-209 of the amino acid sequence represented by UniProtKB:O43353. UniProtKB:O43353, Lys-209, MOD:01148." [PRO:DNx, Reactome:R-HSA-706483]
comment: Category=organism-modification.
synonym: "hRIPK2/Ubiq:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O43353, Lys-209, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-706483 "PR:000049046 located_in GO:0005829"
is_a: PR:O43353 ! receptor-interacting serine/threonine-protein kinase 2 (human)
relationship: has_part MOD:01148 ! ubiquitinylated lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O43353
name: receptor-interacting serine/threonine-protein kinase 2 (human)
def: "A receptor-interacting serine/threonine-protein kinase 2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O43353]
comment: Category=organism-gene.
synonym: "RICK" RELATED Gene-based [UniProtKB:O43353]
synonym: "RIP2" RELATED Gene-based [UniProtKB:O43353]
synonym: "RIPK2" RELATED Gene-based [UniProtKB:O43353]
synonym: "hRIPK2" EXACT PRO-short-label [PRO:DNx]
synonym: "CARDIAK" RELATED Gene-based [UniProtKB:O43353]
synonym: "RIP-2 (human)" EXACT [UniProtKB:O43353]
synonym: "UNQ277/PRO314/PRO34092" RELATED Gene-based [UniProtKB:O43353]
synonym: "tyrosine-protein kinase RIPK2 (human)" EXACT [UniProtKB:O43353]
synonym: "receptor-interacting protein 2 (human)" EXACT [UniProtKB:O43353]
synonym: "RIP-like-interacting CLARP kinase (human)" EXACT [UniProtKB:O43353]
synonym: "CARD-containing IL-1 beta ICE-kinase (human)" EXACT [UniProtKB:O43353]
synonym: "CARD-containing interleukin-1 beta-converting enzyme-associated kinase (human)" EXACT [UniProtKB:O43353]
xref: Reactome:R-HSA-168402 "PR:O43353 located_in GO:0005829"
xref: DTO:03100451
xref: UniProtKB:O43353
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000014023 ! receptor-interacting serine/threonine-protein kinase 2
relationship: has_gene_template HGNC:10020 ! RIPK2 (human)