[Term]
id: PR:P17405-1
name: sphingomyelin phosphodiesterase isoform h1 (human)
def: "A sphingomyelin phosphodiesterase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P17405-1." [PRO:DNx, UniProtKB:P17405]
comment: Category=organism-sequence.
synonym: "hSMPD1/iso:h1" EXACT PRO-short-label [PRO:DNx]
synonym: "sphingomyelin phosphodiesterase isoform ASM-1 (human)" EXACT [UniProtKB:P17405]
xref: UniProtKB:P17405-1
is_a: PR:P17405 ! sphingomyelin phosphodiesterase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q04519
name: sphingomyelin phosphodiesterase (mouse)
def: "A sphingomyelin phosphodiesterase that is encoded in the genome of mouse." [OMA:Q04519, PRO:DNx]
comment: Category=organism-gene.
synonym: "Asm" RELATED Gene-based [UniProtKB:Q04519]
synonym: "Smpd1" RELATED Gene-based [UniProtKB:Q04519]
synonym: "mSMPD1" EXACT PRO-short-label [PRO:DNx]
synonym: "ASMase (mouse)" EXACT [UniProtKB:Q04519]
synonym: "acid sphingomyelinase (mouse)" EXACT [UniProtKB:Q04519]
xref: UniProtKB:Q04519
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000015292 ! sphingomyelin phosphodiesterase
relationship: has_gene_template MGI:98325 ! Smpd1 (mouse)

[Term]
id: PR:P17405-3
name: sphingomyelin phosphodiesterase isoform h3 (human)
def: "A sphingomyelin phosphodiesterase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P17405-3." [PRO:DNx, UniProtKB:P17405]
comment: Category=organism-sequence.
synonym: "hSMPD1/iso:h3" EXACT PRO-short-label [PRO:DNx]
synonym: "sphingomyelin phosphodiesterase isoform ASM-3 (human)" EXACT [UniProtKB:P17405]
xref: UniProtKB:P17405-3
is_a: PR:P17405 ! sphingomyelin phosphodiesterase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P17405-2
name: sphingomyelin phosphodiesterase isoform h2 (human)
def: "A sphingomyelin phosphodiesterase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P17405-2." [PRO:DNx, UniProtKB:P17405]
comment: Category=organism-sequence.
synonym: "hSMPD1/iso:h2" EXACT PRO-short-label [PRO:DNx]
synonym: "sphingomyelin phosphodiesterase isoform ASM-2 (human)" EXACT [UniProtKB:P17405]
xref: UniProtKB:P17405-2
is_a: PR:P17405 ! sphingomyelin phosphodiesterase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P17405-4
name: sphingomyelin phosphodiesterase isoform h4 (human)
def: "A sphingomyelin phosphodiesterase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P17405-4." [PRO:DNx, UniProtKB:P17405]
comment: Category=organism-sequence.
synonym: "hSMPD1/iso:h4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P17405-4
is_a: PR:P17405 ! sphingomyelin phosphodiesterase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q23498
name: sphingomyelin phosphodiesterase 2 (worm)
def: "A sphingomyelin phosphodiesterase that is encoded in the genome of worm." [OMA:Q23498, PRO:DNx]
comment: Category=organism-gene.
synonym: "asm-2" RELATED Gene-based [UniProtKB:Q23498]
synonym: "ZK455.4" RELATED Gene-based [UniProtKB:Q23498]
synonym: "ASM-2 (worm)" EXACT [UniProtKB:Q23498]
synonym: "SMPD1 (worm)" EXACT PRO-short-label [PRO:DNx]
synonym: "acid sphingomyelinase 2 (worm)" EXACT [UniProtKB:Q23498]
xref: UniProtKB:Q23498
intersection_of: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans
intersection_of: PR:000015292 ! sphingomyelin phosphodiesterase
relationship: has_gene_template WormBase:WBGene00000212 ! asm-2 (worm)

[Term]
id: PR:000055943
name: sphingomyelin phosphodiesterase N-glycosylated 1 (human)
def: "A sphingomyelin phosphodiesterase (human) that has been N-glycosylated at the residue equivalent to Asn-88 of the amino acid sequence represented by UniProtKB:P17405-1, in which the glycan composition is represented by GlyTouCan:G36670VW. Example: UniProtKB:P17405-1, Asn-88, MOD:00160~GNO:G36670VW." [GlyGen:P17405-1, PMID:29671580, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hSMPD1/NGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P17405-1, Asn-88, MOD:00160~GNO:G36670VW" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P17405 ! sphingomyelin phosphodiesterase (human)
relationship: has_part GNO:G36670VW ! G36670VW
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000021511
name: sphingomyelin phosphodiesterase, signal peptide removed form
def: "A sphingomyelin phosphodiesterase that has had the signal peptide removed." [PRO:DNx]
comment: Category=modification.
synonym: "SMPD1/SigPep-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000015292 ! sphingomyelin phosphodiesterase
intersection_of: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:000049300
name: sphingomyelin phosphodiesterase, signal peptide removed form (human)
def: "A sphingomyelin phosphodiesterase (human) that has had the signal peptide removed. UniProtKB:P17405, 47-629." [PRO:DNx, Reactome:R-HSA-1605710]
comment: Category=organism-modification.
synonym: "PRO_0000002323" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hSMPD1/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P17405, 47-629" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-1605710 "PR:000049300 located_in GO:0043202"
intersection_of: PR:P17405 ! sphingomyelin phosphodiesterase (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P17405
name: sphingomyelin phosphodiesterase (human)
def: "A sphingomyelin phosphodiesterase that is encoded in the genome of human." [PRO:DNx, UniProtKB:P17405]
comment: Category=organism-gene.
synonym: "ASM" RELATED Gene-based [UniProtKB:P17405]
synonym: "SMPD1" RELATED Gene-based [UniProtKB:P17405]
synonym: "hSMPD1" EXACT PRO-short-label [PRO:DNx]
synonym: "aSMase (human)" EXACT [UniProtKB:P17405]
synonym: "acid sphingomyelinase (human)" EXACT [UniProtKB:P17405]
xref: UniProtKB:P17405
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000015292 ! sphingomyelin phosphodiesterase
relationship: has_gene_template HGNC:11120 ! SMPD1 (human)

[Term]
id: PR:000015292
name: sphingomyelin phosphodiesterase
def: "A protein that is a translation product of the human SMPD1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "ASM" RELATED Gene-based []
synonym: "SMPD1" EXACT PRO-short-label [PRO:DNx]
synonym: "aSMase" EXACT []
synonym: "acid sphingomyelinase" EXACT []
xref: IUPHARobj:2514
is_a: PR:000000001 ! protein

[Term]
id: PR:000045691
name: sphingomyelin phosphodiesterase phosphorylated 1 (human)
def: "A sphingomyelin phosphodiesterase (human) that has been phosphorylated on the residue at the position equivalent to Ser-510 of the amino acid sequence represented by UniProtKB:P17405-1. Example: UniProtKB:P17405-1, Ser-510, MOD:00046." [PMID:17303575, PRO:DAN, iPTMnet:P17405]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:17303575). Note: The modified site indicated here (Ser-510) is referred to as Ser-508 in the literature, likely based on a two-residue-shorter isoform (UniProtKB:E9LUE6). [PRO:DAN, PMID:17303575]
synonym: "hSMPD1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P17405-1, Ser-510, MOD:00046" NARROW PRO-proteoform-std [PRO:DAN]
is_a: PR:P17405 ! sphingomyelin phosphodiesterase (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q5XIA6
name: sphingomyelin phosphodiesterase (rat)
def: "A sphingomyelin phosphodiesterase that is encoded in the genome of rat." [OMA:Q5XIA6, PRO:DNx]
comment: Category=organism-gene.
synonym: "rSMPD1" EXACT PRO-short-label [PRO:DNx]
synonym: "rCG_39318" RELATED Gene-based [UniProtKB:Q5XIA6]
xref: UniProtKB:Q5XIA6
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000015292 ! sphingomyelin phosphodiesterase
relationship: has_gene_template RGD:1549719 ! Smpd1 (rat)