[Term] id: PR:P37840-3 name: alpha-synuclein isoform h2-5 (human) def: "An alpha-synuclein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P37840-3." [PRO:DNx, UniProtKB:P37840] comment: Category=organism-sequence. synonym: "hSNCA/iso:h2-5" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P37840-3 is_a: PR:P37840 ! alpha-synuclein (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000046117 name: alpha-synuclein phosphorylated 1 (mouse) def: "An alpha-synuclein (mouse) that has been phosphorylated on the residue at the position equivalent to Ser-129 of the amino acid sequence represented by UniProtKB:O55042-1. Example: UniProtKB:O55042-1, Ser-129, MOD:00046." [PMID:15304353, iPTMnet:O55042] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:15304353). Status=unreviewed. synonym: "mSNCA/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:O55042-1, Ser-129, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx] is_a: PR:O55042 ! alpha-synuclein (mouse) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus [Term] id: PR:000049305 name: alpha-synuclein ubiquitinated form (human) def: "An alpha-synuclein (human) that includes at least one ubiquitinated lysine. UniProtKB:P37840, MOD:01148." [PRO:DNx, Reactome:R-HSA-5660754] comment: Category=organism-modification. synonym: "hSNCA/UbiqLys+" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P37840, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-5660754 "PR:000049305 located_in GO:0005829" intersection_of: has_part MOD:01148 ! ubiquitinylated lysine intersection_of: PR:P37840 ! alpha-synuclein (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000039381 name: alpha-synuclein isoform 1 def: "An alpha-synuclein that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P37840-1 or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=sequence. synonym: "SNCA/iso:1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000015322 ! alpha-synuclein [Term] id: PR:P37840 name: alpha-synuclein (human) def: "An alpha-synuclein that is encoded in the genome of human." [PRO:DNx, UniProtKB:P37840] comment: Category=organism-gene. synonym: "NACP" RELATED Gene-based [UniProtKB:P37840] synonym: "SNCA" RELATED Gene-based [UniProtKB:P37840] synonym: "PARK1" RELATED Gene-based [UniProtKB:P37840] synonym: "hSNCA" EXACT PRO-short-label [PRO:DNx] synonym: "non-A beta component of AD amyloid (human)" EXACT [UniProtKB:P37840] synonym: "non-A4 component of amyloid precursor (human)" EXACT [UniProtKB:P37840] xref: Reactome:R-HSA-976954 "PR:P37840 located_in GO:0005576" xref: Reactome:R-HSA-5658500 "PR:P37840 located_in GO:0005829" xref: UniProtKB:P37840 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000015322 ! alpha-synuclein relationship: has_gene_template HGNC:11138 ! SNCA (human) [Term] id: PR:P37377-2 name: alpha-synuclein isoform rSyn2 (rat) def: "An alpha-synuclein (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P37377-2." [PRO:DNx, UniProtKB:P37377] comment: Category=organism-sequence. synonym: "rSNCA/iso:rSyn2" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P37377-2 is_a: PR:P37377 ! alpha-synuclein (rat) relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus [Term] id: PR:P37377 name: alpha-synuclein (rat) def: "An alpha-synuclein that is encoded in the genome of rat." [OMA:P37377, PANTHER:PTHR13820:SF5, PRO:DNx] comment: Category=organism-gene. synonym: "Snca" RELATED Gene-based [UniProtKB:P37377] synonym: "rSNCA" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P37377 intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus intersection_of: PR:000015322 ! alpha-synuclein relationship: has_gene_template RGD:3729 ! Snca (rat) [Term] id: PR:P37377-3 name: alpha-synuclein isoform rSyn3 (rat) def: "An alpha-synuclein (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P37377-3." [PRO:DNx, UniProtKB:P37377] comment: Category=organism-sequence. synonym: "rSNCA/iso:rSyn3" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P37377-3 is_a: PR:P37377 ! alpha-synuclein (rat) relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus [Term] id: PR:000015322 name: alpha-synuclein def: "A protein that is a translation product of the human SNCA gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "Syn" RELATED Gene-based [] synonym: "NACP" RELATED Gene-based [] synonym: "SNCA" EXACT PRO-short-label [PRO:DNx] synonym: "PARK1" RELATED Gene-based [] synonym: "non-A beta component of AD amyloid" EXACT [] synonym: "non-A4 component of amyloid precursor" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:P37377-1 name: alpha-synuclein isoform Syn1 (rat) def: "An alpha-synuclein isoform 1 that is encoded in the genome of rat." [PRO:DNx] comment: Category=organism-sequence. synonym: "rSNCA/iso:Syn1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P37377-1 intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus intersection_of: PR:000039381 ! alpha-synuclein isoform 1 [Term] id: PR:O55042 name: alpha-synuclein (mouse) def: "An alpha-synuclein that is encoded in the genome of mouse." [OMA:O55042, PRO:DNx] comment: Category=organism-gene. synonym: "Syn" RELATED Gene-based [UniProtKB:O55042] synonym: "Snca" RELATED Gene-based [UniProtKB:O55042] synonym: "mSNCA" EXACT PRO-short-label [PRO:DNx] synonym: "NACP (mouse)" EXACT [UniProtKB:O55042] synonym: "non-A beta component of AD amyloid (mouse)" EXACT [UniProtKB:O55042] synonym: "non-A4 component of amyloid precursor (mouse)" EXACT [UniProtKB:O55042] xref: UniProtKB:O55042 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000015322 ! alpha-synuclein relationship: has_gene_template MGI:1277151 ! Snca (mouse) [Term] id: PR:O55042-2 name: alpha-synuclein isoform m2 (mouse) def: "An alpha-synuclein (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O55042-2." [PRO:DNx, UniProtKB:O55042] comment: Category=organism-sequence. synonym: "mSNCA/iso:m2" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:O55042-2 is_a: PR:O55042 ! alpha-synuclein (mouse) relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus [Term] id: PR:P37840-2 name: alpha-synuclein isoform h2-4 (human) def: "An alpha-synuclein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P37840-2." [PRO:DNx, UniProtKB:P37840] comment: Category=organism-sequence. synonym: "hSNCA/iso:h2-4" EXACT PRO-short-label [PRO:DNx] synonym: "alpha-synuclein isoform NACP112 (human)" EXACT [UniProtKB:P37840] xref: UniProtKB:P37840-2 is_a: PR:P37840 ! alpha-synuclein (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:O55042-1 name: alpha-synuclein isoform 1 (mouse) def: "An alpha-synuclein isoform 1 that is encoded in the genome of mouse." [PRO:DNx] comment: Category=organism-sequence. synonym: "mSNCA/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:O55042-1 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000039381 ! alpha-synuclein isoform 1 [Term] id: PR:P37840-1 name: alpha-synuclein isoform 1 (human) def: "An alpha-synuclein isoform 1 that is encoded in the genome of human." [PRO:DNx] comment: Category=organism-sequence. synonym: "hSNCA/iso:1" EXACT PRO-short-label [PRO:DNx] synonym: "alpha-synuclein isoform NACP140 (human)" EXACT [UniProtKB:P37840] xref: UniProtKB:P37840-1 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000039381 ! alpha-synuclein isoform 1 [Term] id: PR:000045769 name: alpha-synuclein phosphorylated 1 (human) def: "An alpha-synuclein (human) that has been phosphorylated on the residue at the position equivalent to Tyr-125 of the amino acid sequence represented by UniProtKB:P37840-1. Example: UniProtKB:P37840-1, Tyr-125, MOD:00048." [PMID:12893833, iPTMnet:P37840] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:12893833). Status=unreviewed. synonym: "hSNCA/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P37840-1, Tyr-125, MOD:00048" NARROW PRO-proteoform-std [PRO:DNx] is_a: PR:P37840 ! alpha-synuclein (human) relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens