[Term]
id: PR:000049953
name: tyrosine 3-monooxygenase phosphorylated 1 (mouse)
def: "A tyrosine 3-monooxygenase phosphorylated 1 in mouse. UniProtKB:P24529, Ser-31, MOD:00046." [PMID:28637871]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:28637871).
synonym: "mTH/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "THSer(P)-31 (mouse)" EXACT [PMID:28637871]
synonym: "UniProtKB:P24529, Ser-31, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000049952 ! tyrosine 3-monooxygenase phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000049436
name: tyrosine 3-monooxygenase, initiator methionine removed form (human)
def: "A tyrosine 3-monooxygenase (human) that has had the initiator methionine removed. UniProtKB:P07101, 2-528." [PRO:DNx, Reactome:R-HSA-2980863]
comment: Category=organism-modification.
synonym: "hTH/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000205561" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P07101, 2-528" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-2980863 "PR:000049436 located_in GO:0005829"
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:P07101 ! tyrosine 3-monooxygenase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P90986
name: tyrosine 3-monooxygenase (worm)
def: "A tyrosine 3-monooxygenase that is encoded in the genome of worm." [PRO:DNx]
comment: Category=organism-gene.
synonym: "cat-2" RELATED Gene-based [UniProtKB:P90986]
synonym: "B0432.5" RELATED Gene-based [UniProtKB:P90986]
synonym: "TH (worm)" EXACT PRO-short-label [PRO:DNx]
synonym: "tyrosine 3-hydroxylase (worm)" EXACT [UniProtKB:P90986]
synonym: "abnormal catecholamine distribution protein 2 (worm)" EXACT [UniProtKB:P90986]
xref: UniProtKB:P90986
intersection_of: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans
intersection_of: PR:000016301 ! tyrosine 3-monooxygenase
relationship: has_gene_template WormBase:WBGene00000296 ! cat-2 (worm)

[Term]
id: PR:P07101-1
name: tyrosine 3-monooxygenase isoform h3 (human)
def: "A tyrosine 3-monooxygenase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P07101-1." [PRO:DNx, UniProtKB:P07101]
comment: Category=organism-sequence.
synonym: "hTH/iso:h3" EXACT PRO-short-label [PRO:DNx]
synonym: "tyrosine 3-monooxygenase isoform TH type 4 (human)" EXACT [UniProtKB:P07101]
xref: UniProtKB:P07101-1
is_a: PR:P07101 ! tyrosine 3-monooxygenase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P07101-3
name: tyrosine 3-monooxygenase isoform h2 (human)
def: "A tyrosine 3-monooxygenase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P07101-3." [PRO:DNx, UniProtKB:P07101]
comment: Category=organism-sequence.
synonym: "hTH/iso:h2" EXACT PRO-short-label [PRO:DNx]
synonym: "tyrosine 3-monooxygenase isoform HTH-1 (human)" EXACT [UniProtKB:P07101]
synonym: "tyrosine 3-monooxygenase isoform TH type 1 (human)" EXACT [UniProtKB:P07101]
synonym: "tyrosine 3-monooxygenase isoform hTH-Delta1b,2 (human)" EXACT [UniProtKB:P07101]
xref: UniProtKB:P07101-3
is_a: PR:P07101 ! tyrosine 3-monooxygenase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P07101-2
name: tyrosine 3-monooxygenase isoform h1 (human)
def: "A tyrosine 3-monooxygenase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P07101-2." [PRO:DNx, UniProtKB:P07101]
comment: Category=organism-sequence.
synonym: "hTH/iso:h1" EXACT PRO-short-label [PRO:DNx]
synonym: "tyrosine 3-monooxygenase isoform TH type 3 (human)" EXACT [UniProtKB:P07101]
xref: UniProtKB:P07101-2
is_a: PR:P07101 ! tyrosine 3-monooxygenase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P07101-5
name: tyrosine 3-monooxygenase isoform h5 (human)
def: "A tyrosine 3-monooxygenase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P07101-5." [PRO:DNx, UniProtKB:P07101]
comment: Category=organism-sequence.
synonym: "hTH/iso:h5" EXACT PRO-short-label [PRO:DNx]
synonym: "tyrosine 3-monooxygenase isoform hTH-Delta2,8,9 (human)" EXACT [UniProtKB:P07101]
xref: UniProtKB:P07101-5
is_a: PR:P07101 ! tyrosine 3-monooxygenase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P07101-4
name: tyrosine 3-monooxygenase isoform h4 (human)
def: "A tyrosine 3-monooxygenase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P07101-4." [PRO:DNx, UniProtKB:P07101]
comment: Category=organism-sequence.
synonym: "hTH/iso:h4" EXACT PRO-short-label [PRO:DNx]
synonym: "tyrosine 3-monooxygenase isoform TH type 2 (human)" EXACT [UniProtKB:P07101]
synonym: "tyrosine 3-monooxygenase isoform hTH-Delta2 (human)" EXACT [UniProtKB:P07101]
xref: UniProtKB:P07101-4
is_a: PR:P07101 ! tyrosine 3-monooxygenase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P07101-6
name: tyrosine 3-monooxygenase isoform h6 (human)
def: "A tyrosine 3-monooxygenase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P07101-6." [PRO:DNx, UniProtKB:P07101]
comment: Category=organism-sequence.
synonym: "hTH/iso:h6" EXACT PRO-short-label [PRO:DNx]
synonym: "tyrosine 3-monooxygenase isoform hTH-Delta1b,2,8,9 (human)" EXACT [UniProtKB:P07101]
xref: UniProtKB:P07101-6
is_a: PR:P07101 ! tyrosine 3-monooxygenase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P17289
name: tyrosine 3-monooxygenase (cow)
def: "A tyrosine 3-monooxygenase that is encoded in the genome of cow." [OMA:P17289, PRO:DNx]
comment: Category=organism-gene. Requested by=PubChem.
synonym: "TH" RELATED Gene-based [UniProtKB:P17289]
synonym: "cow-TH" EXACT PRO-short-label [PRO:DNx]
synonym: "tyrosine 3-hydroxylase (cow)" EXACT [UniProtKB:P17289]
xref: UniProtKB:P17289
intersection_of: only_in_taxon NCBITaxon:9913 ! Bos taurus
intersection_of: PR:000016301 ! tyrosine 3-monooxygenase
relationship: has_gene_template NCBIGene:280707 ! TH (cow)

[Term]
id: PR:P24529
name: tyrosine 3-monooxygenase (mouse)
def: "A tyrosine 3-monooxygenase that is encoded in the genome of mouse." [OMA:P24529, PRO:DNx]
comment: Category=organism-gene.
synonym: "Th" RELATED Gene-based [UniProtKB:P24529]
synonym: "mTH" EXACT PRO-short-label [PRO:DNx]
synonym: "TH (mouse)" EXACT [UniProtKB:P24529]
synonym: "tyrosine 3-hydroxylase (mouse)" EXACT [UniProtKB:P24529]
xref: UniProtKB:P24529
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000016301 ! tyrosine 3-monooxygenase
relationship: has_gene_template MGI:98735 ! Th (mouse)

[Term]
id: PR:000046122
name: tyrosine 3-monooxygenase phosphorylated 1 (rat)
def: "A tyrosine 3-monooxygenase phosphorylated 1 in rat. UniProtKB:P04177, Ser-31, MOD:00046." [PMID:1347949, PRO:CNA, iPTMnet:P04177]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:1347949).
synonym: "rTH/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P04177, Ser-31, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000049952 ! tyrosine 3-monooxygenase phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:P18459
name: tyrosine 3-monooxygenase (fruit fly)
def: "A tyrosine 3-monooxygenase that is encoded in the genome of fruit fly." [OMA:P18459, PRO:DNx]
comment: Category=organism-gene.
synonym: "TH" RELATED Gene-based [UniProtKB:P18459]
synonym: "ple" RELATED Gene-based [UniProtKB:P18459]
synonym: "fly-TH" EXACT PRO-short-label [PRO:DNx]
synonym: "CG10118" RELATED Gene-based [UniProtKB:P18459]
synonym: "protein Pale (fruit fly)" EXACT [UniProtKB:P18459]
synonym: "tyrosine 3-hydroxylase (fruit fly)" EXACT [UniProtKB:P18459]
xref: UniProtKB:P18459
intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster
intersection_of: PR:000016301 ! tyrosine 3-monooxygenase
relationship: has_gene_template FlyBase:FBgn0005626 ! ple (fruit fly)

[Term]
id: PR:P04177-1
name: tyrosine 3-monooxygenase isoform 1 (rat)
def: "A tyrosine 3-monooxygenase isoform 1 that is encoded in the genome of rat." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "rTH/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P04177-1
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000039116 ! tyrosine 3-monooxygenase isoform 1

[Term]
id: PR:000039116
name: tyrosine 3-monooxygenase isoform 1
def: "A tyrosine 3-monooxygenase that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P24529-1 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "TH/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000016301 ! tyrosine 3-monooxygenase

[Term]
id: PR:P04177
name: tyrosine 3-monooxygenase (rat)
def: "A tyrosine 3-monooxygenase that is encoded in the genome of rat." [OMA:P04177, PRO:DNx]
comment: Category=organism-gene.
synonym: "Th" RELATED Gene-based [UniProtKB:P04177]
synonym: "rTH" EXACT PRO-short-label [PRO:DNx]
synonym: "TH (rat)" EXACT [UniProtKB:P04177]
synonym: "tyrosine 3-hydroxylase (rat)" EXACT [UniProtKB:P04177]
xref: UniProtKB:P04177
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000016301 ! tyrosine 3-monooxygenase
relationship: has_gene_template RGD:3853 ! Th (rat)

[Term]
id: PR:P18459-2
name: tyrosine 3-monooxygenase isoform Hypodermal (fruit fly)
def: "A tyrosine 3-monooxygenase (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P18459-2." [PRO:DNx, UniProtKB:P18459]
comment: Category=organism-sequence.
synonym: "fly-TH/iso:Hypodermal" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P18459-2
is_a: PR:P18459 ! tyrosine 3-monooxygenase (fruit fly)
relationship: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster

[Term]
id: PR:P18459-1
name: tyrosine 3-monooxygenase isoform Neuronal (fruit fly)
def: "A tyrosine 3-monooxygenase (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P18459-1." [PRO:DNx, UniProtKB:P18459]
comment: Category=organism-sequence.
synonym: "fly-TH/iso:Neuronal" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P18459-1
is_a: PR:P18459 ! tyrosine 3-monooxygenase (fruit fly)
relationship: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster

[Term]
id: PR:000049952
name: tyrosine 3-monooxygenase phosphorylated 1
def: "A tyrosine 3-monooxygenase that has been phosphorylated on the residue at the position equivalent to Ser-31 of the amino acid sequence represented by UniProtKB:P04177. Example: UniProtKB:P04177, Ser-31, MOD:00046." [PMID:1347949, PMID:28637871]
comment: Category=modification.
synonym: "TH/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "THSer(P)-31" EXACT [PMID:28637871]
is_a: PR:000016301 ! tyrosine 3-monooxygenase
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:P24529-1
name: tyrosine 3-monooxygenase isoform 1 (mouse)
def: "A tyrosine 3-monooxygenase isoform 1 that is encoded in the genome of mouse." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "mTH/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P24529-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000039116 ! tyrosine 3-monooxygenase isoform 1

[Term]
id: PR:P07101
name: tyrosine 3-monooxygenase (human)
def: "A tyrosine 3-monooxygenase that is encoded in the genome of human." [PRO:DNx, UniProtKB:P07101]
comment: Category=organism-gene.
synonym: "TH" RELATED Gene-based [UniProtKB:P07101]
synonym: "TYH" RELATED Gene-based [UniProtKB:P07101]
synonym: "hTH" EXACT PRO-short-label [PRO:DNx]
synonym: "tyrosine 3-hydroxylase (human)" EXACT [UniProtKB:P07101]
xref: UniProtKB:P07101
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000016301 ! tyrosine 3-monooxygenase
relationship: has_gene_template HGNC:11782 ! TH (human)

[Term]
id: PR:000016301
name: tyrosine 3-monooxygenase
def: "A protein that is a translation product of the human TH gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "TH" EXACT PRO-short-label [PRO:DNx]
synonym: "TYH" RELATED Gene-based []
synonym: "tyrosine 3-hydroxylase" EXACT []
xref: IUPHARobj:1243
is_a: PR:000000001 ! protein