[Term]
id: PR:Q9WUL0-1
name: DNA topoisomerase 1 isoform 1 (rat)
def: "A type 1B DNA topoisomerase 1 isoform 1 that is encoded in the genome of rat." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "rTOP1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9WUL0-1
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000040273 ! type 1B DNA topoisomerase 1 isoform 1

[Term]
id: PR:000049508
name: DNA topoisomerase 1, initiator methionine removed form (human)
def: "A DNA topoisomerase 1 (human) that has had the initiator methionine removed. UniProtKB:P11387, 2-765." [PRO:DNx, Reactome:R-HSA-4641363]
comment: Category=organism-modification.
synonym: "PRO_0000145201" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hTOP1/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P11387, 2-765" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-4641363 "PR:000049508 located_in GO:0005654"
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:P11387 ! DNA topoisomerase 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000049509
name: DNA topoisomerase 1, initiator methionine removed sumoylated 1 (human)
def: "A DNA topoisomerase 1 (human) that has had the initiator methionine removed and has been post-translationally modified to include sumoylated lysine at position 117 of the amino acid sequence represented by UniProtKB:P11387. UniProtKB:P11387, 2-765, Lys-117, MOD:01149." [PRO:DNx, Reactome:R-HSA-4641364]
comment: Category=organism-modification.
synonym: "hTOP1/InitMet-/Sumo:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000145201, Lys-117, MOD:01149" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P11387, 2-765, Lys-117, MOD:01149" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-4641364 "PR:000049509 located_in GO:0005654"
is_a: PR:P11387 ! DNA topoisomerase 1 (human)
relationship: has_part MOD:01149 ! sumoylated lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000040273
name: type 1B DNA topoisomerase 1 isoform 1
def: "A type 1B DNA topoisomerase 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q04750-1 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "TOP1/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000016542 ! type 1B DNA topoisomerase 1

[Term]
id: PR:P11387
name: DNA topoisomerase 1 (human)
def: "A type 1B DNA topoisomerase 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P11387]
comment: Category=organism-gene.
synonym: "TOP1" RELATED Gene-based [UniProtKB:P11387]
synonym: "hTOP1" EXACT PRO-short-label [PRO:DNx]
synonym: "DNA topoisomerase I (human)" EXACT [UniProtKB:P11387]
xref: UniProtKB:P11387
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000016542 ! type 1B DNA topoisomerase 1
relationship: has_gene_template HGNC:11986 ! TOP1 (human)

[Term]
id: PR:000021719
name: type 1B DNA topoisomerase 1, initiator methionine removed form
def: "A type 1B DNA topoisomerase 1 that has had the initiator methionine removed." [PRO:DNx]
comment: Category=modification.
synonym: "TOP1/InitMet-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000016542 ! type 1B DNA topoisomerase 1
intersection_of: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:Q04750-1
name: DNA topoisomerase 1 isoform 1 (mouse)
def: "A type 1B DNA topoisomerase 1 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "mTOP1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q04750-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000040273 ! type 1B DNA topoisomerase 1 isoform 1

[Term]
id: PR:000016542
name: type 1B DNA topoisomerase 1
def: "A protein that is a translation product of the human TOP1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "TOP1" EXACT PRO-short-label [PRO:DNx]
synonym: "Top-1" RELATED Gene-based []
synonym: "DNA topoisomerase I" BROAD [PRO:DNx]
xref: IUPHARobj:2636
is_a: PR:000000001 ! protein

[Term]
id: PR:Q9WUL0
name: DNA topoisomerase 1 (rat)
def: "A type 1B DNA topoisomerase 1 that is encoded in the genome of rat." [OMA:Q9WUL0, PRO:DNx]
comment: Category=organism-gene.
synonym: "Top1" RELATED Gene-based [UniProtKB:Q9WUL0]
synonym: "rTOP1" EXACT PRO-short-label [PRO:DNx]
synonym: "DNA topoisomerase I (rat)" EXACT [UniProtKB:Q9WUL0]
xref: UniProtKB:Q9WUL0
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000016542 ! type 1B DNA topoisomerase 1
relationship: has_gene_template RGD:621246 ! Top1 (rat)

[Term]
id: PR:Q04750
name: DNA topoisomerase 1 (mouse)
def: "A type 1B DNA topoisomerase 1 that is encoded in the genome of mouse." [OMA:Q04750, PRO:DNx]
comment: Category=organism-gene.
synonym: "Top1" RELATED Gene-based [UniProtKB:Q04750]
synonym: "Top-1" RELATED Gene-based [UniProtKB:Q04750]
synonym: "mTOP1" EXACT PRO-short-label [PRO:DNx]
synonym: "DNA topoisomerase I (mouse)" EXACT [UniProtKB:Q04750]
xref: UniProtKB:Q04750
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000016542 ! type 1B DNA topoisomerase 1
relationship: has_gene_template MGI:98788 ! Top1 (mouse)

[Term]
id: PR:P30189
name: DNA topoisomerase 1 (fruit fly)
def: "A type 1B DNA topoisomerase 1 that is encoded in the genome of fruit fly." [PANTHER:PTHR10290:SF0, PRO:DNx]
comment: Category=organism-gene.
synonym: "Top1" RELATED Gene-based [UniProtKB:P30189]
synonym: "CG6146" RELATED Gene-based [UniProtKB:P30189]
synonym: "fly-TOP1" EXACT PRO-short-label [PRO:DNx]
synonym: "DNA topoisomerase I (fruit fly)" EXACT [UniProtKB:P30189]
xref: UniProtKB:P30189
intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster
intersection_of: PR:000016542 ! type 1B DNA topoisomerase 1
relationship: has_gene_template FlyBase:FBgn0004924 ! Top1 (fruit fly)